YMR034C_p

Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR034C / YMR034C

Click on Significant Values for Screen Details ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.21|P-value:2.48E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.23|P-value:9.14E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.49|P-value:3.89E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.08|P-value:4.14E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:-5.31|P-value:1.49E-7 ID:SGTC_728|Compound:3030-5151|FD-Score:-4.57|P-value:5.07E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.24|P-value:8.77E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-4.01|P-value:5.35E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-4.97|P-value:8.12E-7 ID:SGTC_732|Compound:3970-1727|FD-Score:-3.31|P-value:6.91E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.82|P-value:1.11E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:4.28|P-value:1.87E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:4.01|P-value:5.44E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.79|P-value:1.27E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.27|P-value:8.02E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.49|P-value:3.70E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.47|P-value:4.08E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.66|P-value:2.06E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.37|P-value:5.90E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.40|P-value:5.06E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.22|P-value:9.59E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-4.21|P-value:2.37E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:4.10|P-value:3.80E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.76|P-value:1.40E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.93|P-value:7.38E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.87|P-value:7.20E-9 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.73|P-value:1.60E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.31|P-value:6.86E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.20|P-value:2.54E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.46|P-value:8.73E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.39|P-value:5.46E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.55|P-value:3.14E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.71|P-value:1.77E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.21|P-value:2.48E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.23|P-value:9.14E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.49|P-value:3.89E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.08|P-value:4.14E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:-5.31|P-value:1.49E-7 ID:SGTC_728|Compound:3030-5151|FD-Score:-4.57|P-value:5.07E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.24|P-value:8.77E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-4.01|P-value:5.35E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-4.97|P-value:8.12E-7 ID:SGTC_732|Compound:3970-1727|FD-Score:-3.31|P-value:6.91E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.82|P-value:1.11E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:4.28|P-value:1.87E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:4.01|P-value:5.44E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.79|P-value:1.27E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.27|P-value:8.02E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.49|P-value:3.70E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.47|P-value:4.08E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.66|P-value:2.06E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.37|P-value:5.90E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.40|P-value:5.06E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.22|P-value:9.59E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-4.21|P-value:2.37E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:4.10|P-value:3.80E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.76|P-value:1.40E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.93|P-value:7.38E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.87|P-value:7.20E-9 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.73|P-value:1.60E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.31|P-value:6.86E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.20|P-value:2.54E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.46|P-value:8.73E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.39|P-value:5.46E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.55|P-value:3.14E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.71|P-value:1.77E-4

Top fitness defect scores for YMR034C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2755 lomerizine 4.46 42.7 µM 8.73E-6 20 4.19E-6
2 SGTC_776 4476-4378 4.28 112.0 µM 1.87E-5 ERG2 16 9.45E-6
3 SGTC_436 n,n-dimethylsphingosine 4.21 3.3 µM 2.48E-5 20 1.28E-5
4 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.20 3.7 µM 2.54E-5 70 1.32E-5
5 SGTC_1588 farnesol 4.10 29.9 µM 3.80E-5 6 2.03E-5
6 SGTC_669 0108-0021 4.08 26.2 µM 4.14E-5 fatty acid desaturase (OLE1) 73 2.22E-5
7 SGTC_778 3456-2434 4.01 196.0 µM 5.44E-5 mitochondrial response to ROS 71 2.98E-5
8 SGTC_1929 genistein trimethyl ether 3.73 50.5 µM 1.60E-4 21 9.46E-5
9 SGTC_2962 9082311 3.71 13.2 µM 1.77E-4 27 1.05E-4
10 SGTC_2795 7780010 3.55 54.5 µM 3.14E-4 48 1.94E-4
11 SGTC_597 k018-0003 3.49 82.8 µM 3.89E-4 RNA pol III & RNase P/MRP 21 2.44E-4
12 SGTC_2762 leflunomide 3.39 42.1 µM 5.46E-4 54 3.52E-4
13 SGTC_1419 3993-2473 3.37 62.6 µM 5.90E-4 36 3.82E-4
14 SGTC_966 1300-0360 3.27 30.2 µM 8.02E-4 heme requiring 52 5.31E-4
15 SGTC_1567 st069303 3.22 68.4 µM 9.59E-4 mitochondrial processes 46 6.42E-4
16 SGTC_603 3794-0023 3.19 45.9 µM 0.00105 28 7.11E-4
17 SGTC_664 1222-0054 3.16 14.9 µM 0.00118 sphingolipid biosynthesis & PDR1 65 7.99E-4
18 SGTC_2166 5933061 3.15 31.5 µM 0.00120 tubulin folding & SWR complex 77 8.16E-4
19 SGTC_2979 9012552 3.15 45.5 µM 0.00121 22 8.25E-4
20 SGTC_6 0844-0013 3.11 19.8 µM 0.00136 187 9.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 6.61E-21 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.151 1.41E-18 YKR039W GAP1 hom General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth
0.144 4.20E-17 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.138 8.37E-16 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.137 1.98E-15 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.136 3.14E-15 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.136 3.05E-15 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.129 5.32E-14 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.129 5.77E-14 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.126 2.32E-13 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.126 2.62E-13 YLR406C-A_p YLR406C-A_p hom Putative protein of unknown function
0.125 3.97E-13 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.123 8.38E-13 YLR398C SKI2 hom Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.122 1.61E-12 YBR220C_p YBR220C_p hom Putative protein of unknown function; YBR220C is not an essential gene
0.121 1.64E-12 YLR334C_d YLR334C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here