YMR036C / MIH1

Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR036C / MIH1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.28|P-value:8.28E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:4.50|P-value:1.15E-7 ID:SGTC_393|Compound:acivicin|FD-Score:-2.78|P-value:6.98E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-3.43|P-value:3.96E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.99|P-value:2.25E-6 ID:SGTC_408|Compound:cantharidin|FD-Score:-3.43|P-value:4.11E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:2.86|P-value:5.15E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.94|P-value:2.95E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.11|P-value:1.74E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:14.80|P-value:2.11E-65 ID:SGTC_716|Compound:1683-5115|FD-Score:2.95|P-value:3.57E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.95|P-value:6.39E-9 ID:SGTC_779|Compound:1360-0071|FD-Score:2.79|P-value:6.85E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.16|P-value:1.43E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.58|P-value:1.94E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.44|P-value:3.95E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.34|P-value:6.19E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.13|P-value:1.84E-9 ID:SGTC_1190|Compound:1486-1332|FD-Score:-2.99|P-value:2.91E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.53|P-value:2.43E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.56|P-value:2.10E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.46|P-value:3.56E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.97|P-value:3.25E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.12|P-value:1.68E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.95|P-value:3.52E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.42|P-value:4.25E-5 ID:SGTC_1433|Compound:4060-0023|FD-Score:2.86|P-value:5.02E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:2.76|P-value:7.69E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-4.17|P-value:8.11E-7 ID:SGTC_1779|Compound:st039427|FD-Score:3.19|P-value:1.26E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.47|P-value:3.34E-5 ID:SGTC_2256|Compound:7954252|FD-Score:-2.96|P-value:3.32E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.18|P-value:1.30E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.02|P-value:2.60E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.16|P-value:1.44E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.45|P-value:1.56E-7 ID:SGTC_3288|Compound:9119690|FD-Score:-2.99|P-value:2.98E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-5.81|P-value:1.19E-11 ID:SGTC_3311|Compound:9131146|FD-Score:8.16|P-value:3.43E-21 ID:SGTC_3321|Compound:9137793|FD-Score:7.27|P-value:3.24E-17 ID:SGTC_65|Compound:0798-0905|FD-Score:3.28|P-value:8.28E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:4.50|P-value:1.15E-7 ID:SGTC_393|Compound:acivicin|FD-Score:-2.78|P-value:6.98E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-3.43|P-value:3.96E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.99|P-value:2.25E-6 ID:SGTC_408|Compound:cantharidin|FD-Score:-3.43|P-value:4.11E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:2.86|P-value:5.15E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.94|P-value:2.95E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.11|P-value:1.74E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:14.80|P-value:2.11E-65 ID:SGTC_716|Compound:1683-5115|FD-Score:2.95|P-value:3.57E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.95|P-value:6.39E-9 ID:SGTC_779|Compound:1360-0071|FD-Score:2.79|P-value:6.85E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.16|P-value:1.43E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.58|P-value:1.94E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.44|P-value:3.95E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.34|P-value:6.19E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.13|P-value:1.84E-9 ID:SGTC_1190|Compound:1486-1332|FD-Score:-2.99|P-value:2.91E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.53|P-value:2.43E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.56|P-value:2.10E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.46|P-value:3.56E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.97|P-value:3.25E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.12|P-value:1.68E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.95|P-value:3.52E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.42|P-value:4.25E-5 ID:SGTC_1433|Compound:4060-0023|FD-Score:2.86|P-value:5.02E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:2.76|P-value:7.69E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-4.17|P-value:8.11E-7 ID:SGTC_1779|Compound:st039427|FD-Score:3.19|P-value:1.26E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.47|P-value:3.34E-5 ID:SGTC_2256|Compound:7954252|FD-Score:-2.96|P-value:3.32E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.18|P-value:1.30E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.02|P-value:2.60E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.16|P-value:1.44E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.45|P-value:1.56E-7 ID:SGTC_3288|Compound:9119690|FD-Score:-2.99|P-value:2.98E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-5.81|P-value:1.19E-11 ID:SGTC_3311|Compound:9131146|FD-Score:8.16|P-value:3.43E-21 ID:SGTC_3321|Compound:9137793|FD-Score:7.27|P-value:3.24E-17

Top fitness defect scores for YMR036C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_514 4466-0038 14.80 2.6 nM 2.11E-65 cell wall 6 4.75E-50
2 SGTC_3311 9131146 8.16 2.9 µM 3.43E-21 cell wall 32 1.68E-16
3 SGTC_3321 9137793 7.27 26.8 µM 3.24E-17 cell wall 15 1.76E-13
4 SGTC_304 1310-0298 4.50 97.0 µM 1.15E-7 cell wall 41 3.37E-6
5 SGTC_2919 7978188 4.45 46.4 µM 1.56E-7 12 4.24E-6
6 SGTC_405 ebelactone b 3.99 50.0 µM 2.25E-6 16 3.28E-5
7 SGTC_483 fpl-64176 3.94 144.0 µM 2.95E-6 cell wall 12 4.03E-5
8 SGTC_916 4466-0038 3.58 42.0 nM 1.94E-5 cell wall 90 1.71E-4
9 SGTC_1211 1056-0033 3.46 32.3 µM 3.56E-5 20 2.73E-4
10 SGTC_1090 efavirenz 3.44 20.7 µM 3.95E-5 40 2.96E-4
11 SGTC_1100 amiodarone 3.34 5.1 µM 6.19E-5 33 4.18E-4
12 SGTC_65 0798-0905 3.28 35.0 µM 8.28E-5 calcium & mitochondrial duress 134 5.23E-4
13 SGTC_1779 st039427 3.19 55.0 µM 1.26E-4 57 7.21E-4
14 SGTC_2309 7664088 3.18 163.9 µM 1.30E-4 86 7.39E-4
15 SGTC_2584 androsterone 3.16 48.7 µM 1.44E-4 cell wall 195 8.02E-4
16 SGTC_1270 0831-1170 3.12 17.3 µM 1.68E-4 37 9.02E-4
17 SGTC_2310 7668677 3.02 200.0 µM 2.60E-4 88 0.00126
18 SGTC_1263 0774-1208 2.97 64.8 µM 3.25E-4 118 0.00150
19 SGTC_1291 0993-0025 2.95 5.8 µM 3.52E-4 38 0.00160
20 SGTC_716 1683-5115 2.95 658.0 µM 3.57E-4 70 0.00161

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.437 1.17E-156 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.430 2.73E-151 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.381 4.27E-116 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.363 1.00E-104 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.357 1.57E-101 YOR195W SLK19 hom Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
0.345 1.80E-94 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.345 2.41E-94 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.338 1.02E-90 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.310 7.41E-76 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.290 8.75E-66 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.285 6.87E-64 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.280 2.90E-61 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.274 1.23E-58 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.273 1.51E-58 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.268 3.44E-56 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data