YMR042W / ARG80

Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR042W / ARG80

Click on Significant Values for Screen Details ID:SGTC_166|Compound:k072-0058|FD-Score:3.12|P-value:7.00E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.12|P-value:6.65E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.22|P-value:4.97E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.09|P-value:1.32E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:3.62|P-value:1.06E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.40|P-value:2.53E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-4.67|P-value:7.93E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.27|P-value:6.19E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.31|P-value:3.53E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.21|P-value:4.84E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.34|P-value:3.21E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.38|P-value:2.55E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.70|P-value:7.74E-5 ID:SGTC_1617|Compound:st002906|FD-Score:3.84|P-value:4.19E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.43|P-value:2.27E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.94|P-value:2.58E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.72|P-value:6.94E-5 ID:SGTC_2309|Compound:7664088|FD-Score:-3.08|P-value:7.81E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.32|P-value:3.22E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.90|P-value:3.32E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.20|P-value:5.33E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.70|P-value:7.63E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.02|P-value:1.93E-5 ID:SGTC_2816|Compound:7982706|FD-Score:3.71|P-value:7.23E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-3.46|P-value:1.91E-4 ID:SGTC_2847|Compound:9005661|FD-Score:-3.64|P-value:9.03E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.28|P-value:3.96E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.01|P-value:9.99E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-3.65|P-value:8.69E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:3.12|P-value:7.00E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.12|P-value:6.65E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.22|P-value:4.97E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.09|P-value:1.32E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:3.62|P-value:1.06E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.40|P-value:2.53E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-4.67|P-value:7.93E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.27|P-value:6.19E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.31|P-value:3.53E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.21|P-value:4.84E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.34|P-value:3.21E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.38|P-value:2.55E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.70|P-value:7.74E-5 ID:SGTC_1617|Compound:st002906|FD-Score:3.84|P-value:4.19E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.43|P-value:2.27E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.94|P-value:2.58E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.72|P-value:6.94E-5 ID:SGTC_2309|Compound:7664088|FD-Score:-3.08|P-value:7.81E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.32|P-value:3.22E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.90|P-value:3.32E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.20|P-value:5.33E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.70|P-value:7.63E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.02|P-value:1.93E-5 ID:SGTC_2816|Compound:7982706|FD-Score:3.71|P-value:7.23E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-3.46|P-value:1.91E-4 ID:SGTC_2847|Compound:9005661|FD-Score:-3.64|P-value:9.03E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.28|P-value:3.96E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.01|P-value:9.99E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-3.65|P-value:8.69E-5

Top fitness defect scores for YMR042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1072 oxiconazole 4.27 14.9 nM 6.19E-6 ergosterol depletion effects on membrane 46 9.84E-6
2 SGTC_2405 ticlatone 4.02 3.5 µM 1.93E-5 67 2.91E-5
3 SGTC_2352 9027995 3.90 87.8 µM 3.32E-5 tubulin folding & SWR complex 32 4.89E-5
4 SGTC_1617 st002906 3.84 78.0 µM 4.19E-5 28 6.11E-5
5 SGTC_2302 7771753 3.72 200.0 µM 6.94E-5 50 9.88E-5
6 SGTC_2816 7982706 3.71 58.4 µM 7.23E-5 azole & statin 62 1.03E-4
7 SGTC_2365 9042475 3.70 200.0 µM 7.63E-5 47 1.08E-4
8 SGTC_1616 st002734 3.70 56.1 µM 7.74E-5 36 1.10E-4
9 SGTC_836 0330-0104 3.62 1.4 µM 1.06E-4 24 1.48E-4
10 SGTC_1865 st057639 3.43 52.2 µM 2.27E-4 29 3.07E-4
11 SGTC_867 0518-0118 3.40 155.0 µM 2.53E-4 DNA intercalators 39 3.40E-4
12 SGTC_1459 k035-0031 3.34 35.7 µM 3.21E-4 DNA intercalators 40 4.26E-4
13 SGTC_1137 ixabepilone 3.31 100.0 µM 3.53E-4 61 4.67E-4
14 SGTC_2940 9060638 3.28 45.9 µM 3.96E-4 amide catabolism 52 5.21E-4
15 SGTC_423 5-fluorouracil 3.22 457.0 µM 4.97E-4 exosome 54 6.47E-4
16 SGTC_2360 9040895 3.20 200.0 µM 5.33E-4 RPP1 & pyrimidine depletion 37 6.92E-4
17 SGTC_166 k072-0058 3.12 166.4 µM 7.00E-4 DNA intercalators 73 8.98E-4
18 SGTC_872 0588-0139 2.91 234.0 µM 0.00145 86 0.00180
19 SGTC_3077 9117319 2.88 49.5 µM 0.00158 47 0.00196
20 SGTC_2984 9022109 2.88 39.0 µM 0.00158 38 0.00196

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 8.91E-27 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.121 2.03E-12 YKL143W LTV1 hom Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
0.114 4.10E-11 YER003C PMI40 het Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
0.102 2.86E-9 YDR060W MAK21 het Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.102 3.79E-9 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.101 5.23E-9 YDR362C TFC6 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
0.097 2.15E-8 YJR079W_p YJR079W_p hom Putative protein of unknown function; mutation results in impaired mitochondrial respiration
0.094 5.79E-8 YDR196C CAB5 het Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies
0.092 1.04E-7 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.092 1.07E-7 YOR119C RIO1 het Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
0.087 4.22E-7 YDR082W STN1 het Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping
0.087 5.60E-7 YHR039C MSC7 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
0.086 7.31E-7 YML079W_p YML079W_p hom Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm
0.083 1.50E-6 YDL074C BRE1 hom E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
0.081 2.50E-6 YFL011W HXT10 hom Putative hexose transporter, expressed at low levels and expression is repressed by glucose