YMR081C / ISF1

Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR081C / ISF1

Click on Significant Values for Screen Details ID:SGTC_153|Compound:4077-0274|FD-Score:3.37|P-value:1.53E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.46|P-value:1.05E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:5.19|P-value:1.35E-8 ID:SGTC_369|Compound:0957-0393|FD-Score:-5.38|P-value:3.85E-9 ID:SGTC_370|Compound:0180-0345|FD-Score:-4.65|P-value:3.08E-7 ID:SGTC_508|Compound:roscovitine|FD-Score:3.11|P-value:4.27E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.08|P-value:4.85E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.39|P-value:1.42E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.69|P-value:3.76E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:-2.97|P-value:7.21E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.05|P-value:7.17E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:3.38|P-value:1.44E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:2.94|P-value:8.20E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.18|P-value:3.29E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.61|P-value:5.36E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.67|P-value:6.24E-10 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.99|P-value:9.38E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.04|P-value:3.29E-8 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.09|P-value:4.71E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.07|P-value:4.98E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.00|P-value:8.88E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.89|P-value:1.55E-5 ID:SGTC_1398|Compound:3558-0053|FD-Score:-2.90|P-value:9.16E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-2.98|P-value:7.05E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.02|P-value:6.05E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.12|P-value:4.16E-4 ID:SGTC_1697|Compound:st025554|FD-Score:-3.22|P-value:2.80E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.29|P-value:2.06E-4 ID:SGTC_1783|Compound:st039459|FD-Score:2.94|P-value:8.08E-4 ID:SGTC_1829|Compound:berberine|FD-Score:2.95|P-value:7.96E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.02|P-value:6.09E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.77|P-value:2.61E-5 ID:SGTC_1936|Compound:st074407|FD-Score:4.26|P-value:2.45E-6 ID:SGTC_2020|Compound:4017018|FD-Score:3.06|P-value:5.19E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:5.73|P-value:4.11E-10 ID:SGTC_2686|Compound:alizarin|FD-Score:4.00|P-value:9.25E-6 ID:SGTC_2842|Compound:9000675|FD-Score:3.38|P-value:1.48E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.91|P-value:1.37E-5 ID:SGTC_3080|Compound:9117754|FD-Score:3.30|P-value:2.06E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.15|P-value:4.30E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:3.37|P-value:1.53E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.46|P-value:1.05E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:5.19|P-value:1.35E-8 ID:SGTC_369|Compound:0957-0393|FD-Score:-5.38|P-value:3.85E-9 ID:SGTC_370|Compound:0180-0345|FD-Score:-4.65|P-value:3.08E-7 ID:SGTC_508|Compound:roscovitine|FD-Score:3.11|P-value:4.27E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.08|P-value:4.85E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.39|P-value:1.42E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.69|P-value:3.76E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:-2.97|P-value:7.21E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.05|P-value:7.17E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:3.38|P-value:1.44E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:2.94|P-value:8.20E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.18|P-value:3.29E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.61|P-value:5.36E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.67|P-value:6.24E-10 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.99|P-value:9.38E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.04|P-value:3.29E-8 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.09|P-value:4.71E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.07|P-value:4.98E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.00|P-value:8.88E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.89|P-value:1.55E-5 ID:SGTC_1398|Compound:3558-0053|FD-Score:-2.90|P-value:9.16E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-2.98|P-value:7.05E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.02|P-value:6.05E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.12|P-value:4.16E-4 ID:SGTC_1697|Compound:st025554|FD-Score:-3.22|P-value:2.80E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.29|P-value:2.06E-4 ID:SGTC_1783|Compound:st039459|FD-Score:2.94|P-value:8.08E-4 ID:SGTC_1829|Compound:berberine|FD-Score:2.95|P-value:7.96E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.02|P-value:6.09E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.77|P-value:2.61E-5 ID:SGTC_1936|Compound:st074407|FD-Score:4.26|P-value:2.45E-6 ID:SGTC_2020|Compound:4017018|FD-Score:3.06|P-value:5.19E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:5.73|P-value:4.11E-10 ID:SGTC_2686|Compound:alizarin|FD-Score:4.00|P-value:9.25E-6 ID:SGTC_2842|Compound:9000675|FD-Score:3.38|P-value:1.48E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.91|P-value:1.37E-5 ID:SGTC_3080|Compound:9117754|FD-Score:3.30|P-value:2.06E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.15|P-value:4.30E-6

Top fitness defect scores for YMR081C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2583 asiatic acid 5.73 100.0 µM 4.11E-10 16 5.05E-9
2 SGTC_1029 k015-0030 5.67 64.7 µM 6.24E-10 8 7.27E-9
3 SGTC_368 fentichlor 5.19 4.6 µM 1.35E-8 8 1.06E-7
4 SGTC_1040 k898-0338 5.04 155.0 µM 3.29E-8 9 2.32E-7
5 SGTC_1936 st074407 4.26 74.3 µM 2.45E-6 DNA damage response 26 1.01E-5
6 SGTC_3337 9144342 4.15 33.5 µM 4.30E-6 24 1.65E-5
7 SGTC_931 2812-0076 4.05 566.0 µM 7.17E-6 24 2.58E-5
8 SGTC_1330 1469-0054 4.00 61.8 µM 8.88E-6 iron homeostasis 16 3.11E-5
9 SGTC_2686 alizarin 4.00 95.4 µM 9.25E-6 RPP1 & pyrimidine depletion 29 3.22E-5
10 SGTC_1033 k072-0102 3.99 21.3 µM 9.38E-6 60S ribosome export 20 3.26E-5
11 SGTC_3028 9087778 3.91 49.5 µM 1.37E-5 13 4.55E-5
12 SGTC_1391 3442-0225 3.89 151.0 µM 1.55E-5 17 5.07E-5
13 SGTC_895 0964-0006 3.69 13.7 µM 3.76E-5 20 1.10E-4
14 SGTC_1006 4099-6547 3.61 255.0 µM 5.36E-5 32 1.50E-4
15 SGTC_309 k408-0051 3.46 1.5 µM 1.05E-4 84 2.71E-4
16 SGTC_828 2074-0507 3.39 139.0 µM 1.42E-4 RPP1 & pyrimidine depletion 37 3.53E-4
17 SGTC_936 3005-4620 3.38 401.0 µM 1.44E-4 48 3.58E-4
18 SGTC_2842 9000675 3.38 19.5 µM 1.48E-4 43 3.66E-4
19 SGTC_153 4077-0274 3.37 519.7 µM 1.53E-4 33 3.77E-4
20 SGTC_3080 9117754 3.30 49.5 µM 2.06E-4 41 4.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 7.15E-14 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.114 4.19E-11 YPL192C PRM3 hom Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body
0.104 1.30E-9 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.095 3.10E-8 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.092 8.11E-8 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.089 2.18E-7 YLR398C SKI2 hom Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.089 2.55E-7 YCR026C NPP1 hom Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication
0.088 2.90E-7 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.087 3.96E-7 YGR030C POP6 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.087 5.00E-7 YJL211C_d YJL211C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
0.085 7.65E-7 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.085 8.35E-7 YBR276C PPS1 hom Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
0.084 1.01E-6 YOR292C_p YOR292C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
0.084 1.25E-6 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 1.74E-6 YNL057W_d YNL057W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data