HIPHOP chemogenomics database

YMR092C / AIP1

Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR092C / AIP1

Click on Significant Values for Screen Details

Top fitness defect scores for YMR092C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1567	st069303	6.21	68.4 µM	2.19E-11	mitochondrial processes	3	2.60E-10
2	SGTC_164	4100-3994	4.56	89.6 µM	6.73E-7		17	2.57E-6
3	SGTC_2384	9036245	4.48	200.0 µM	1.00E-6		23	3.66E-6
4	SGTC_1853	st056710	3.99	91.2 µM	1.16E-5	amide catabolism	23	3.27E-5
5	SGTC_1858	4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione	3.96	62.6 µM	1.33E-5	TSC3-RPN4	16	3.68E-5
6	SGTC_2398	5228213	3.90	48.8 µM	1.80E-5	iron homeostasis	41	4.84E-5
7	SGTC_2099	5377090	3.82	177.4 µM	2.60E-5		26	6.69E-5
8	SGTC_419	nsc-638432	3.79	893.0 µM	2.92E-5	DNA damage response	13	7.44E-5
9	SGTC_1417	3966-0327	3.65	90.4 µM	5.51E-5		22	1.31E-4
10	SGTC_2053	5265679	3.59	138.0 µM	7.25E-5		35	1.67E-4
11	SGTC_3240	9133527	3.48	49.5 µM	1.12E-4		21	2.47E-4
12	SGTC_684	1140-0066	3.46	328.0 µM	1.26E-4	Golgi	49	2.75E-4
13	SGTC_1288	0973-0013	3.40	65.5 µM	1.60E-4		34	3.40E-4
14	SGTC_1145	3546-0597	3.40	10.2 µM	1.60E-4	mitochondrial processes	35	3.41E-4
15	SGTC_179	1273-0063	3.40	6.8 µM	1.61E-4		32	3.41E-4
16	SGTC_2001	4023502	3.31	57.7 µM	2.32E-4	mitochondrial processes	42	4.73E-4
17	SGTC_2394	5221648	3.25	200.0 µM	2.93E-4		53	5.84E-4
18	SGTC_1409	3909-8004	3.22	61.9 µM	3.30E-4		52	6.50E-4
19	SGTC_2010	4012422	3.14	159.0 µM	4.42E-4		56	8.45E-4
20	SGTC_2810	7959871	3.14	45.5 µM	4.48E-4	copper-dependent oxidative stress	80	8.54E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.142	1.19E-16	YHR086W	NAM8	hom	RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
0.137	1.56E-15	YOR338W_p	YOR338W_p	hom	Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication
0.107	4.74E-10	YPL011C	TAF3	het	TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.105	1.04E-9	YOR097C_p	YOR097C_p	hom	Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene
0.102	3.21E-9	YPR154W	PIN3	hom	Protein that induces appearance of [PIN+] prion when overproduced
0.096	2.15E-8	YGR091W	PRP31	het	Splicing factor, component of the U4/U6-U5 snRNP complex
0.092	8.21E-8	YBR080C	SEC18	het	ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF
0.086	6.59E-7	YLR132C	USB1	het	Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.084	1.11E-6	YPR055W	SEC8	het	Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.081	2.98E-6	YIL164C	NIT1	hom	Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
0.080	3.73E-6	YNL189W	SRP1	het	Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
0.078	6.76E-6	YKR075C_p	YKR075C_p	hom	Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.077	7.92E-6	YKR011C	YKR011C	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress
0.074	1.94E-5	YCR022C_d	YCR022C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
0.074	2.00E-5	YBR200W-A_p	YBR200W-A_p	hom	Putative protein of unknown function; identified by fungal homology and RT-PCR