YMR092C / AIP1

Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR092C / AIP1

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:-3.03|P-value:6.22E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:4.56|P-value:6.73E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.58|P-value:6.65E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:3.40|P-value:1.61E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.79|P-value:2.92E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:2.99|P-value:7.80E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-3.29|P-value:2.22E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.46|P-value:1.26E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.02|P-value:7.03E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.09|P-value:5.32E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.40|P-value:1.60E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-3.47|P-value:1.06E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.40|P-value:1.60E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.22|P-value:3.30E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.65|P-value:5.51E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.02|P-value:6.94E-4 ID:SGTC_1567|Compound:st069303|FD-Score:6.21|P-value:2.19E-11 ID:SGTC_1571|Compound:st070080|FD-Score:3.10|P-value:5.11E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.53|P-value:8.32E-5 ID:SGTC_1677|Compound:st019204|FD-Score:-3.81|P-value:2.41E-5 ID:SGTC_1850|Compound:st056238|FD-Score:-3.10|P-value:4.76E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.99|P-value:1.16E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.96|P-value:1.33E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.31|P-value:2.32E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.14|P-value:4.42E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.59|P-value:7.25E-5 ID:SGTC_2099|Compound:5377090|FD-Score:3.82|P-value:2.60E-5 ID:SGTC_2141|Compound:5621638|FD-Score:2.93|P-value:9.73E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.04|P-value:6.37E-4 ID:SGTC_2384|Compound:9036245|FD-Score:4.48|P-value:1.00E-6 ID:SGTC_2387|Compound:9077560|FD-Score:-3.26|P-value:2.56E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-2.98|P-value:7.48E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.25|P-value:2.93E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.90|P-value:1.80E-5 ID:SGTC_2458|Compound:5808907|FD-Score:3.07|P-value:5.73E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.14|P-value:4.48E-4 ID:SGTC_2834|Compound:9001755|FD-Score:2.94|P-value:9.33E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.07|P-value:5.75E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.03|P-value:6.77E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.69|P-value:4.27E-5 ID:SGTC_3041|Compound:9091929|FD-Score:-3.28|P-value:2.34E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.38|P-value:1.57E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.07|P-value:5.77E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.48|P-value:1.12E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.03|P-value:6.22E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:4.56|P-value:6.73E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.58|P-value:6.65E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:3.40|P-value:1.61E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.79|P-value:2.92E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:2.99|P-value:7.80E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-3.29|P-value:2.22E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.46|P-value:1.26E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.02|P-value:7.03E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.09|P-value:5.32E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.40|P-value:1.60E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-3.47|P-value:1.06E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.40|P-value:1.60E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.22|P-value:3.30E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.65|P-value:5.51E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.02|P-value:6.94E-4 ID:SGTC_1567|Compound:st069303|FD-Score:6.21|P-value:2.19E-11 ID:SGTC_1571|Compound:st070080|FD-Score:3.10|P-value:5.11E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.53|P-value:8.32E-5 ID:SGTC_1677|Compound:st019204|FD-Score:-3.81|P-value:2.41E-5 ID:SGTC_1850|Compound:st056238|FD-Score:-3.10|P-value:4.76E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.99|P-value:1.16E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.96|P-value:1.33E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.31|P-value:2.32E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.14|P-value:4.42E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.59|P-value:7.25E-5 ID:SGTC_2099|Compound:5377090|FD-Score:3.82|P-value:2.60E-5 ID:SGTC_2141|Compound:5621638|FD-Score:2.93|P-value:9.73E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.04|P-value:6.37E-4 ID:SGTC_2384|Compound:9036245|FD-Score:4.48|P-value:1.00E-6 ID:SGTC_2387|Compound:9077560|FD-Score:-3.26|P-value:2.56E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-2.98|P-value:7.48E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.25|P-value:2.93E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.90|P-value:1.80E-5 ID:SGTC_2458|Compound:5808907|FD-Score:3.07|P-value:5.73E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.14|P-value:4.48E-4 ID:SGTC_2834|Compound:9001755|FD-Score:2.94|P-value:9.33E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.07|P-value:5.75E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.03|P-value:6.77E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.69|P-value:4.27E-5 ID:SGTC_3041|Compound:9091929|FD-Score:-3.28|P-value:2.34E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.38|P-value:1.57E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.07|P-value:5.77E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.48|P-value:1.12E-4

Top fitness defect scores for YMR092C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1567 st069303 6.21 68.4 µM 2.19E-11 mitochondrial processes 3 2.60E-10
2 SGTC_164 4100-3994 4.56 89.6 µM 6.73E-7 17 2.57E-6
3 SGTC_2384 9036245 4.48 200.0 µM 1.00E-6 23 3.66E-6
4 SGTC_1853 st056710 3.99 91.2 µM 1.16E-5 amide catabolism 23 3.27E-5
5 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 3.96 62.6 µM 1.33E-5 TSC3-RPN4 16 3.68E-5
6 SGTC_2398 5228213 3.90 48.8 µM 1.80E-5 iron homeostasis 41 4.84E-5
7 SGTC_2099 5377090 3.82 177.4 µM 2.60E-5 26 6.69E-5
8 SGTC_419 nsc-638432 3.79 893.0 µM 2.92E-5 DNA damage response 13 7.44E-5
9 SGTC_1417 3966-0327 3.65 90.4 µM 5.51E-5 22 1.31E-4
10 SGTC_2053 5265679 3.59 138.0 µM 7.25E-5 35 1.67E-4
11 SGTC_3240 9133527 3.48 49.5 µM 1.12E-4 21 2.47E-4
12 SGTC_684 1140-0066 3.46 328.0 µM 1.26E-4 Golgi 49 2.75E-4
13 SGTC_1288 0973-0013 3.40 65.5 µM 1.60E-4 34 3.40E-4
14 SGTC_1145 3546-0597 3.40 10.2 µM 1.60E-4 mitochondrial processes 35 3.41E-4
15 SGTC_179 1273-0063 3.40 6.8 µM 1.61E-4 32 3.41E-4
16 SGTC_2001 4023502 3.31 57.7 µM 2.32E-4 mitochondrial processes 42 4.73E-4
17 SGTC_2394 5221648 3.25 200.0 µM 2.93E-4 53 5.84E-4
18 SGTC_1409 3909-8004 3.22 61.9 µM 3.30E-4 52 6.50E-4
19 SGTC_2010 4012422 3.14 159.0 µM 4.42E-4 56 8.45E-4
20 SGTC_2810 7959871 3.14 45.5 µM 4.48E-4 copper-dependent oxidative stress 80 8.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.19E-16 YHR086W NAM8 hom RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
0.137 1.56E-15 YOR338W_p YOR338W_p hom Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication
0.107 4.74E-10 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.105 1.04E-9 YOR097C_p YOR097C_p hom Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene
0.102 3.21E-9 YPR154W PIN3 hom Protein that induces appearance of [PIN+] prion when overproduced
0.096 2.15E-8 YGR091W PRP31 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.092 8.21E-8 YBR080C SEC18 het ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF
0.086 6.59E-7 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.084 1.11E-6 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.081 2.98E-6 YIL164C NIT1 hom Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
0.080 3.73E-6 YNL189W SRP1 het Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
0.078 6.76E-6 YKR075C_p YKR075C_p hom Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.077 7.92E-6 YKR011C YKR011C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress
0.074 1.94E-5 YCR022C_d YCR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
0.074 2.00E-5 YBR200W-A_p YBR200W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR