YMR096W / SNZ1

Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR096W / SNZ1

Click on Significant Values for Screen Details ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.98|P-value:4.20E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:2.85|P-value:6.43E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:-3.14|P-value:2.18E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:4.13|P-value:1.66E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:3.33|P-value:8.74E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:3.22|P-value:1.43E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.05|P-value:3.21E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.64|P-value:9.78E-8 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.86|P-value:6.85E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.00|P-value:3.80E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-5.38|P-value:7.58E-10 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.13|P-value:2.07E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.10|P-value:2.58E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-2.81|P-value:8.24E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.82|P-value:8.39E-6 ID:SGTC_2364|Compound:9055074|FD-Score:-3.44|P-value:5.68E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.58|P-value:3.00E-5 ID:SGTC_2373|Compound:9071805|FD-Score:3.11|P-value:2.27E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.96|P-value:3.93E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.01|P-value:3.68E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-2.98|P-value:4.18E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-4.64|P-value:9.55E-8 ID:SGTC_2485|Compound:5633444|FD-Score:-4.85|P-value:2.58E-8 ID:SGTC_2486|Compound:5283202|FD-Score:5.12|P-value:3.99E-9 ID:SGTC_2665|Compound:lovastatin|FD-Score:-3.38|P-value:7.54E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.81|P-value:9.47E-6 ID:SGTC_2891|Compound:9063876|FD-Score:3.72|P-value:1.35E-5 ID:SGTC_2895|Compound:9054447|FD-Score:2.99|P-value:3.75E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.23|P-value:1.37E-4 ID:SGTC_3015|Compound:9080845|FD-Score:2.77|P-value:8.71E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.91|P-value:1.54E-8 ID:SGTC_3211|Compound:9128781|FD-Score:2.87|P-value:6.02E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.98|P-value:4.20E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:2.85|P-value:6.43E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:-3.14|P-value:2.18E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:4.13|P-value:1.66E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:3.33|P-value:8.74E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:3.22|P-value:1.43E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.05|P-value:3.21E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.64|P-value:9.78E-8 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.86|P-value:6.85E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.00|P-value:3.80E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-5.38|P-value:7.58E-10 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.13|P-value:2.07E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.10|P-value:2.58E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-2.81|P-value:8.24E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.82|P-value:8.39E-6 ID:SGTC_2364|Compound:9055074|FD-Score:-3.44|P-value:5.68E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.58|P-value:3.00E-5 ID:SGTC_2373|Compound:9071805|FD-Score:3.11|P-value:2.27E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.96|P-value:3.93E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.01|P-value:3.68E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-2.98|P-value:4.18E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-4.64|P-value:9.55E-8 ID:SGTC_2485|Compound:5633444|FD-Score:-4.85|P-value:2.58E-8 ID:SGTC_2486|Compound:5283202|FD-Score:5.12|P-value:3.99E-9 ID:SGTC_2665|Compound:lovastatin|FD-Score:-3.38|P-value:7.54E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.81|P-value:9.47E-6 ID:SGTC_2891|Compound:9063876|FD-Score:3.72|P-value:1.35E-5 ID:SGTC_2895|Compound:9054447|FD-Score:2.99|P-value:3.75E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.23|P-value:1.37E-4 ID:SGTC_3015|Compound:9080845|FD-Score:2.77|P-value:8.71E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.91|P-value:1.54E-8 ID:SGTC_3211|Compound:9128781|FD-Score:2.87|P-value:6.02E-4

Top fitness defect scores for YMR096W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2486 5283202 5.12 22.4 µM 3.99E-9 17 1.53E-7
2 SGTC_3203 9113543 4.91 49.5 µM 1.54E-8 11 4.45E-7
3 SGTC_329 k048-0121 4.13 21.3 µM 1.66E-6 RSC & ERG11 10 1.85E-5
4 SGTC_2413 inermin 3.96 26.1 µM 3.93E-6 52 3.68E-5
5 SGTC_2343 7990716 3.82 14.8 µM 8.39E-6 21 6.74E-5
6 SGTC_2891 9063876 3.72 19.5 µM 1.35E-5 11 9.84E-5
7 SGTC_520 3584-0023 3.33 682.0 µM 8.74E-5 48 4.38E-4
8 SGTC_2989 9073649 3.23 71.4 µM 1.37E-4 79 6.28E-4
9 SGTC_874 0599-0792 3.22 117.0 µM 1.43E-4 61 6.51E-4
10 SGTC_1507 4075-3230 3.13 155.0 µM 2.07E-4 25 8.74E-4
11 SGTC_2373 9071805 3.11 200.0 µM 2.27E-4 34 9.41E-4
12 SGTC_2895 9054447 2.99 58.4 µM 3.75E-4 37 0.00141
13 SGTC_3211 9128781 2.87 49.5 µM 6.02E-4 135 0.00206
14 SGTC_315 k915-0449 2.85 187.0 µM 6.43E-4 126 0.00217
15 SGTC_3015 9080845 2.77 49.5 µM 8.71E-4 45 0.00277
16 SGTC_1373 2887-0003 2.74 58.5 µM 0.00100 Golgi 91 0.00309
17 SGTC_420 mitomycin C 2.74 81.9 mM 0.00101 87 0.00310
18 SGTC_716 1683-5115 2.67 658.0 µM 0.00128 102 0.00376
19 SGTC_1264 0783-0040 2.64 158.0 µM 0.00147 101 0.00420
20 SGTC_409 arachidonic acid 2.62 100.0 µM 0.00154 81 0.00437

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 8.96E-28 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.173 6.93E-24 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.169 6.12E-23 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.168 1.64E-22 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.167 2.09E-22 YPL082C MOT1 het Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA
0.162 4.54E-21 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.161 8.28E-21 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.143 7.62E-17 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.143 1.12E-16 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.140 4.55E-16 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.139 6.56E-16 YER062C HOR2 hom Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication
0.139 8.01E-16 YMR244C-A COA6 hom Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress
0.139 6.57E-16 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.139 6.80E-16 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.138 1.07E-15 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress