YMR103C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR103C / YMR103C

Click on Significant Values for Screen Details ID:SGTC_127|Compound:0180-0333|FD-Score:4.82|P-value:1.32E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:3.71|P-value:1.45E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:5.60|P-value:2.39E-8 ID:SGTC_231|Compound:b-estradiol|FD-Score:-3.79|P-value:1.30E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.55|P-value:2.62E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.86|P-value:1.06E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:4.33|P-value:1.18E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.28|P-value:8.04E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.47|P-value:4.25E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.24|P-value:7.59E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.28|P-value:1.50E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:-4.69|P-value:3.10E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:-4.64|P-value:3.87E-6 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.43|P-value:4.00E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.28|P-value:6.67E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.75|P-value:1.24E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.53|P-value:2.83E-4 ID:SGTC_1651|Compound:st011928|FD-Score:-4.40|P-value:1.12E-5 ID:SGTC_1661|Compound:st013063|FD-Score:3.77|P-value:1.15E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.01|P-value:4.58E-5 ID:SGTC_2299|Compound:7976368|FD-Score:-4.56|P-value:5.48E-6 ID:SGTC_2304|Compound:7443016|FD-Score:-3.22|P-value:9.77E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.50|P-value:3.77E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.13|P-value:1.17E-9 ID:SGTC_2623|Compound:humulene|FD-Score:-5.34|P-value:1.27E-7 ID:SGTC_2797|Compound:7859098|FD-Score:3.35|P-value:5.19E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.31|P-value:7.30E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.82|P-value:9.43E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-3.73|P-value:1.66E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.42|P-value:4.99E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.55|P-value:3.17E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.82|P-value:1.32E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:3.71|P-value:1.45E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:5.60|P-value:2.39E-8 ID:SGTC_231|Compound:b-estradiol|FD-Score:-3.79|P-value:1.30E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.55|P-value:2.62E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.86|P-value:1.06E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:4.33|P-value:1.18E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.28|P-value:8.04E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.47|P-value:4.25E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.24|P-value:7.59E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.28|P-value:1.50E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:-4.69|P-value:3.10E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:-4.64|P-value:3.87E-6 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.43|P-value:4.00E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.28|P-value:6.67E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.75|P-value:1.24E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.53|P-value:2.83E-4 ID:SGTC_1651|Compound:st011928|FD-Score:-4.40|P-value:1.12E-5 ID:SGTC_1661|Compound:st013063|FD-Score:3.77|P-value:1.15E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.01|P-value:4.58E-5 ID:SGTC_2299|Compound:7976368|FD-Score:-4.56|P-value:5.48E-6 ID:SGTC_2304|Compound:7443016|FD-Score:-3.22|P-value:9.77E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.50|P-value:3.77E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.13|P-value:1.17E-9 ID:SGTC_2623|Compound:humulene|FD-Score:-5.34|P-value:1.27E-7 ID:SGTC_2797|Compound:7859098|FD-Score:3.35|P-value:5.19E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.31|P-value:7.30E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.82|P-value:9.43E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-3.73|P-value:1.66E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.42|P-value:4.99E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.55|P-value:3.17E-4

Top fitness defect scores for YMR103C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 6.13 100.0 µM 1.17E-9 redox potentiating 152 4.38E-10
2 SGTC_142 0335-0849 5.60 62.7 µM 2.39E-8 ubiquinone biosynthesis & proteasome 69 1.06E-8
3 SGTC_359 0081-0058 4.86 15.9 µM 1.06E-6 60S ribosome export 22 5.85E-7
4 SGTC_127 0180-0333 4.82 59.1 µM 1.32E-6 mitochondrial response to ROS 18 7.32E-7
5 SGTC_513 4245-1575 4.33 41.7 µM 1.18E-5 unfolded protein response 97 7.39E-6
6 SGTC_806 3966-4455 4.28 5.9 µM 1.50E-5 15 9.55E-6
7 SGTC_1855 st056195 4.01 39.6 µM 4.58E-5 60S ribosome export 18 3.09E-5
8 SGTC_2954 9074818 3.82 52.7 µM 9.43E-5 39 6.61E-5
9 SGTC_1661 st013063 3.77 9.7 µM 1.15E-4 29 8.15E-5
10 SGTC_1520 flindersine 3.75 88.0 µM 1.24E-4 37 8.78E-5
11 SGTC_137 0438-0332 3.71 85.4 µM 1.45E-4 ubiquinone biosynthesis & proteasome 137 1.04E-4
12 SGTC_266 formosanin C 3.55 406.0 nM 2.62E-4 sphingolipid biosynthesis & PDR1 78 1.93E-4
13 SGTC_1570 verbenone 3.53 133.0 µM 2.83E-4 27 2.10E-4
14 SGTC_1173 0443-0020 3.43 122.0 µM 4.00E-4 TSC3-RPN4 64 3.02E-4
15 SGTC_2797 7859098 3.35 81.8 µM 5.19E-4 49 3.98E-4
16 SGTC_1207 2099-0101 3.28 141.0 µM 6.67E-4 47 5.17E-4
17 SGTC_802 4112-3352 3.24 742.0 µM 7.59E-4 49 5.93E-4
18 SGTC_505 gw-5074 3.12 63.9 µM 0.00114 91 9.05E-4
19 SGTC_4 0960-0234 3.09 25.7 µM 0.00125 Golgi 37 9.99E-4
20 SGTC_2226 7298446 3.09 200.0 µM 0.00125 12 0.00100

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 3.70E-32 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.193 2.30E-29 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.191 6.44E-29 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.186 1.23E-27 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.185 3.82E-27 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.179 1.38E-25 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.169 8.65E-23 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.162 4.03E-21 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.161 5.19E-21 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.152 6.85E-19 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.152 1.08E-18 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.151 1.30E-18 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.144 4.68E-17 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.144 5.31E-17 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.143 7.73E-17 YOL013C HRD1 hom Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon