YMR106C / YKU80

Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR106C / YKU80

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.74|P-value:1.91E-7 ID:SGTC_170|Compound:4197-0004|FD-Score:3.01|P-value:6.40E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.28|P-value:2.23E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.84|P-value:2.00E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:2.98|P-value:7.19E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:5.63|P-value:8.22E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:4.86|P-value:9.79E-8 ID:SGTC_515|Compound:4092-1064|FD-Score:3.02|P-value:6.18E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-2.89|P-value:9.65E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:2.92|P-value:8.74E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.92|P-value:8.80E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:2.99|P-value:6.84E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:5.54|P-value:1.47E-9 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.51|P-value:1.78E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.17|P-value:1.52E-8 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.04|P-value:5.74E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.08|P-value:4.86E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.34|P-value:1.73E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.20|P-value:3.11E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.27|P-value:2.25E-4 ID:SGTC_1743|Compound:st037606|FD-Score:2.95|P-value:8.02E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.14|P-value:3.77E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.31|P-value:2.01E-4 ID:SGTC_2118|Compound:5526350|FD-Score:2.89|P-value:9.87E-4 ID:SGTC_2206|Compound:7254556|FD-Score:2.96|P-value:7.65E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.92|P-value:7.03E-8 ID:SGTC_2312|Compound:7706453|FD-Score:-4.31|P-value:1.89E-6 ID:SGTC_2315|Compound:7733312|FD-Score:-3.47|P-value:1.00E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.61|P-value:5.65E-5 ID:SGTC_2427|Compound:5545055|FD-Score:2.96|P-value:7.67E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.27|P-value:2.40E-6 ID:SGTC_2442|Compound:5158906|FD-Score:2.93|P-value:8.62E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.24|P-value:2.60E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.15|P-value:3.77E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.73|P-value:3.19E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:3.92|P-value:1.37E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.37|P-value:1.53E-4 ID:SGTC_2537|Compound:larixol|FD-Score:5.92|P-value:1.13E-10 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.89|P-value:9.77E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.16|P-value:3.59E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.06|P-value:5.29E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.02|P-value:6.08E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.99|P-value:9.28E-6 ID:SGTC_2833|Compound:9001315|FD-Score:6.90|P-value:7.34E-14 ID:SGTC_2836|Compound:9010338|FD-Score:-2.95|P-value:7.72E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.39|P-value:1.41E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.45|P-value:1.10E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.17|P-value:3.40E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-3.01|P-value:6.17E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.74|P-value:3.05E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.74|P-value:1.91E-7 ID:SGTC_170|Compound:4197-0004|FD-Score:3.01|P-value:6.40E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.28|P-value:2.23E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.84|P-value:2.00E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:2.98|P-value:7.19E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:5.63|P-value:8.22E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:4.86|P-value:9.79E-8 ID:SGTC_515|Compound:4092-1064|FD-Score:3.02|P-value:6.18E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-2.89|P-value:9.65E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:2.92|P-value:8.74E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.92|P-value:8.80E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:2.99|P-value:6.84E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:5.54|P-value:1.47E-9 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.51|P-value:1.78E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.17|P-value:1.52E-8 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.04|P-value:5.74E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.08|P-value:4.86E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.34|P-value:1.73E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.20|P-value:3.11E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.27|P-value:2.25E-4 ID:SGTC_1743|Compound:st037606|FD-Score:2.95|P-value:8.02E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.14|P-value:3.77E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.31|P-value:2.01E-4 ID:SGTC_2118|Compound:5526350|FD-Score:2.89|P-value:9.87E-4 ID:SGTC_2206|Compound:7254556|FD-Score:2.96|P-value:7.65E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.92|P-value:7.03E-8 ID:SGTC_2312|Compound:7706453|FD-Score:-4.31|P-value:1.89E-6 ID:SGTC_2315|Compound:7733312|FD-Score:-3.47|P-value:1.00E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.61|P-value:5.65E-5 ID:SGTC_2427|Compound:5545055|FD-Score:2.96|P-value:7.67E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.27|P-value:2.40E-6 ID:SGTC_2442|Compound:5158906|FD-Score:2.93|P-value:8.62E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.24|P-value:2.60E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.15|P-value:3.77E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.73|P-value:3.19E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:3.92|P-value:1.37E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.37|P-value:1.53E-4 ID:SGTC_2537|Compound:larixol|FD-Score:5.92|P-value:1.13E-10 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.89|P-value:9.77E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.16|P-value:3.59E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.06|P-value:5.29E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.02|P-value:6.08E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.99|P-value:9.28E-6 ID:SGTC_2833|Compound:9001315|FD-Score:6.90|P-value:7.34E-14 ID:SGTC_2836|Compound:9010338|FD-Score:-2.95|P-value:7.72E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.39|P-value:1.41E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.45|P-value:1.10E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.17|P-value:3.40E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-3.01|P-value:6.17E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.74|P-value:3.05E-5

Top fitness defect scores for YMR106C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2833 9001315 6.90 45.5 µM 7.34E-14 amide catabolism 11 2.60E-12
2 SGTC_2537 larixol 5.92 68.9 µM 1.13E-10 5 1.59E-9
3 SGTC_359 0081-0058 5.63 15.9 µM 8.22E-10 60S ribosome export 12 9.00E-9
4 SGTC_1311 1190-0148 5.54 100.0 µM 1.47E-9 azole & statin 11 1.50E-8
5 SGTC_2305 7443522 4.92 69.2 µM 7.03E-8 3 4.41E-7
6 SGTC_514 4466-0038 4.86 2.6 nM 9.79E-8 cell wall 114 5.90E-7
7 SGTC_58 0957-0393 4.74 9.0 µM 1.91E-7 cell wall 311 1.06E-6
8 SGTC_2438 5259590 4.27 200.0 µM 2.40E-6 14 9.71E-6
9 SGTC_2516 gossypol 3.92 71.5 µM 1.37E-5 13 4.47E-5
10 SGTC_306 1672-3436 3.84 11.6 µM 2.00E-5 Golgi 17 6.25E-5
11 SGTC_2514 salinomycin 3.73 42.7 µM 3.19E-5 53 9.41E-5
12 SGTC_2316 5844804 3.61 197.4 µM 5.65E-5 45 1.55E-4
13 SGTC_2839 9003951 3.39 26.0 µM 1.41E-4 25 3.47E-4
14 SGTC_2535 4',4'-dimethoxydalbergione 3.37 51.2 µM 1.53E-4 DNA damage response 33 3.74E-4
15 SGTC_1973 st070275 3.31 50.2 µM 2.01E-4 27 4.74E-4
16 SGTC_304 1310-0298 3.28 97.0 µM 2.23E-4 cell wall 94 5.18E-4
17 SGTC_2453 5731132 3.24 22.2 µM 2.60E-4 54 5.95E-4
18 SGTC_1707 st032323 3.20 6.3 µM 3.11E-4 DNA damage response 94 6.96E-4
19 SGTC_2978 9011784 3.17 43.0 µM 3.40E-4 69 7.53E-4
20 SGTC_2584 androsterone 3.16 48.7 µM 3.59E-4 cell wall 194 7.89E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.267 8.64E-56 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.236 1.38E-43 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.228 6.58E-41 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.228 1.02E-40 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.223 6.30E-39 YDR096W GIS1 hom Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
0.223 6.71E-39 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.221 3.19E-38 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.219 8.53E-38 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.218 2.49E-37 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.210 1.07E-34 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.209 2.78E-34 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.208 2.91E-34 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.203 1.86E-32 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.195 3.55E-30 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.191 6.88E-29 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication