YMR109W / MYO5

One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR109W / MYO5

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.03|P-value:5.25E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-2.97|P-value:5.97E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:2.87|P-value:9.42E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-5.07|P-value:1.71E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:4.76|P-value:1.23E-7 ID:SGTC_328|Compound:k915-0120|FD-Score:3.10|P-value:4.00E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.78|P-value:1.91E-10 ID:SGTC_910|Compound:3454-3003|FD-Score:3.07|P-value:4.56E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.14|P-value:3.09E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.17|P-value:3.08E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-2.93|P-value:6.98E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:2.94|P-value:7.23E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.26|P-value:5.99E-9 ID:SGTC_1344|Compound:1488-0097|FD-Score:5.64|P-value:4.87E-10 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.72|P-value:2.85E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:2.88|P-value:9.18E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.79|P-value:2.00E-5 ID:SGTC_1635|Compound:st007035|FD-Score:8.95|P-value:1.46E-22 ID:SGTC_1652|Compound:st011932|FD-Score:3.53|P-value:6.72E-5 ID:SGTC_1687|Compound:st020778|FD-Score:2.90|P-value:8.50E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:2.99|P-value:6.02E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.09|P-value:4.22E-4 ID:SGTC_1924|Compound:st058459|FD-Score:4.21|P-value:2.58E-6 ID:SGTC_1927|Compound:st060202|FD-Score:2.87|P-value:9.68E-4 ID:SGTC_2014|Compound:4013930|FD-Score:5.10|P-value:1.62E-8 ID:SGTC_2024|Compound:5144227|FD-Score:2.90|P-value:8.61E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.64|P-value:4.14E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.24|P-value:2.31E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.80|P-value:1.94E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-3.05|P-value:4.47E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.85|P-value:1.34E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.44|P-value:9.76E-5 ID:SGTC_2354|Compound:9060492|FD-Score:2.98|P-value:6.28E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-2.86|P-value:8.99E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-2.89|P-value:8.00E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-5.13|P-value:1.20E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:13.60|P-value:1.71E-49 ID:SGTC_2830|Compound:7992007|FD-Score:-3.18|P-value:2.68E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-3.09|P-value:3.81E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.42|P-value:8.43E-7 ID:SGTC_2961|Compound:9083290|FD-Score:-3.38|P-value:1.14E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.08|P-value:4.34E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-2.98|P-value:5.70E-4 ID:SGTC_3287|Compound:9117173|FD-Score:2.97|P-value:6.62E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.36|P-value:1.38E-4 ID:SGTC_3299|Compound:9121982|FD-Score:2.90|P-value:8.60E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.03|P-value:5.25E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-2.97|P-value:5.97E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:2.87|P-value:9.42E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-5.07|P-value:1.71E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:4.76|P-value:1.23E-7 ID:SGTC_328|Compound:k915-0120|FD-Score:3.10|P-value:4.00E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.78|P-value:1.91E-10 ID:SGTC_910|Compound:3454-3003|FD-Score:3.07|P-value:4.56E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.14|P-value:3.09E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.17|P-value:3.08E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-2.93|P-value:6.98E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:2.94|P-value:7.23E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.26|P-value:5.99E-9 ID:SGTC_1344|Compound:1488-0097|FD-Score:5.64|P-value:4.87E-10 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.72|P-value:2.85E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:2.88|P-value:9.18E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.79|P-value:2.00E-5 ID:SGTC_1635|Compound:st007035|FD-Score:8.95|P-value:1.46E-22 ID:SGTC_1652|Compound:st011932|FD-Score:3.53|P-value:6.72E-5 ID:SGTC_1687|Compound:st020778|FD-Score:2.90|P-value:8.50E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:2.99|P-value:6.02E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.09|P-value:4.22E-4 ID:SGTC_1924|Compound:st058459|FD-Score:4.21|P-value:2.58E-6 ID:SGTC_1927|Compound:st060202|FD-Score:2.87|P-value:9.68E-4 ID:SGTC_2014|Compound:4013930|FD-Score:5.10|P-value:1.62E-8 ID:SGTC_2024|Compound:5144227|FD-Score:2.90|P-value:8.61E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.64|P-value:4.14E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.24|P-value:2.31E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.80|P-value:1.94E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-3.05|P-value:4.47E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.85|P-value:1.34E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.44|P-value:9.76E-5 ID:SGTC_2354|Compound:9060492|FD-Score:2.98|P-value:6.28E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-2.86|P-value:8.99E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-2.89|P-value:8.00E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-5.13|P-value:1.20E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:13.60|P-value:1.71E-49 ID:SGTC_2830|Compound:7992007|FD-Score:-3.18|P-value:2.68E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-3.09|P-value:3.81E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.42|P-value:8.43E-7 ID:SGTC_2961|Compound:9083290|FD-Score:-3.38|P-value:1.14E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.08|P-value:4.34E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-2.98|P-value:5.70E-4 ID:SGTC_3287|Compound:9117173|FD-Score:2.97|P-value:6.62E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.36|P-value:1.38E-4 ID:SGTC_3299|Compound:9121982|FD-Score:2.90|P-value:8.60E-4

Top fitness defect scores for YMR109W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 13.60 100.0 µM 1.71E-49 redox potentiating 23 2.39E-42
2 SGTC_1635 st007035 8.95 42.4 µM 1.46E-22 90 1.83E-19
3 SGTC_673 1082-0474 5.78 110.0 µM 1.91E-10 RSC complex & mRNA processing 24 3.80E-9
4 SGTC_1344 1488-0097 5.64 29.1 µM 4.87E-10 2 8.44E-9
5 SGTC_996 3970-0799 5.26 1.8 µM 5.99E-9 48 7.18E-8
6 SGTC_2014 4013930 5.10 200.0 µM 1.62E-8 6 1.68E-7
7 SGTC_236 1509-0011 4.76 5.3 µM 1.23E-7 338 9.48E-7
8 SGTC_2958 9077254 4.42 16.7 µM 8.43E-7 20 4.92E-6
9 SGTC_1924 st058459 4.21 75.1 µM 2.58E-6 4 1.28E-5
10 SGTC_2133 5320837 3.80 200.0 µM 1.94E-5 ERG2 28 7.21E-5
11 SGTC_1359 1582-0056 3.79 520.0 nM 2.00E-5 23 7.40E-5
12 SGTC_1349 flufenamic acid 3.72 69.0 µM 2.85E-5 20 1.00E-4
13 SGTC_2125 5246583 3.64 200.0 µM 4.14E-5 tubulin folding & SWR complex 51 1.38E-4
14 SGTC_1652 st011932 3.53 78.0 µM 6.72E-5 RSC complex & mRNA processing 25 2.10E-4
15 SGTC_2338 7999974 3.44 200.0 µM 9.76E-5 39 2.89E-4
16 SGTC_3297 9117502 3.36 71.4 µM 1.38E-4 22 3.89E-4
17 SGTC_2130 NSC 7 3.24 2.5 µM 2.31E-4 copper-dependent oxidative stress 70 6.05E-4
18 SGTC_916 4466-0038 3.17 42.0 nM 3.08E-4 cell wall 121 7.75E-4
19 SGTC_328 k915-0120 3.10 63.5 µM 4.00E-4 TSC3-RPN4 43 9.70E-4
20 SGTC_1903 st060211 3.09 78.3 µM 4.22E-4 68 0.00102

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.345 4.37E-94 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.330 8.78E-86 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.329 1.68E-85 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.325 1.43E-83 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.325 2.74E-83 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.323 1.45E-82 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.318 6.66E-80 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.310 1.59E-75 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.304 1.16E-72 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.299 3.38E-70 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.295 1.61E-68 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.295 2.55E-68 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.294 5.38E-68 YHR013C ARD1 hom Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress
0.294 7.25E-68 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.293 2.23E-67 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p