Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress

Zygosity: Homozygous strain
Profile for YMR111C / YMR111C

Click on Significant Values for Screen Details

Top fitness defect scores for YMR111C deletion by condition

RankScreen IDConditionFD ScoreConc
1 SGTC_58 0957-0393 5.47 9.0 µM 3.21E-10 cell wall 244 2.23E-8
2 SGTC_1270 0831-1170 3.77 17.3 µM 1.04E-5 14 8.17E-5
3 SGTC_1176 0848-0131 3.60 83.3 µM 2.45E-5 Golgi 30 1.61E-4
4 SGTC_807 1315-0151 3.27 48.0 µM 1.12E-4 52 5.40E-4
5 SGTC_2329 6138490 3.27 200.0 µM 1.13E-4 64 5.44E-4
6 SGTC_798 1287-0182 3.19 476.0 µM 1.58E-4 52 7.09E-4
7 SGTC_1183 1254-0324 2.93 198.0 µM 4.81E-4 62 0.00172
8 SGTC_886 0866-0150 2.90 153.0 µM 5.26E-4 70 0.00185
9 SGTC_2358 9037157 2.88 4.0 µM 5.69E-4 81 0.00197
10 SGTC_2045 5106652 2.75 78.0 µM 9.43E-4 63 0.00295
11 SGTC_739 1486-1183 2.70 203.0 µM 0.00114 70 0.00342
12 SGTC_2362 9071156 2.69 126.0 µM 0.00118 73 0.00352
13 SGTC_2103 5378138 2.68 10.0 µM 0.00123 90 0.00365
14 SGTC_2754 granisetron 2.59 64.0 µM 0.00173 131 0.00478
15 SGTC_1246 0422-0085 2.56 105.0 µM 0.00194 136 0.00525
16 SGTC_2638 epoxomicin 2.56 18.0 µM 0.00194 103 0.00525
17 SGTC_810 3825-7150 2.54 143.0 µM 0.00207 60S ribosome export 79 0.00552
18 SGTC_2625 euphol 2.52 100.0 µM 0.00226 139 0.00593
19 SGTC_2435 5706476 2.46 10.6 µM 0.00276 129 0.00696
20 SGTC_2640 pentamidine 2.45 10.4 µM 0.00288 mitochondrial processes 151 0.00720

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.341 4.72E-92 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.325 1.57E-83 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.304 1.55E-72 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.301 2.60E-71 YGL134W PCL10 hom Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
0.274 5.16E-59 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.268 4.36E-56 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.267 7.91E-56 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.265 5.56E-55 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.253 2.69E-50 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.249 1.33E-48 YPR023C EAF3 hom Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
0.246 2.07E-47 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.240 3.21E-45 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.238 1.45E-44 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.234 6.82E-43 YDL189W RBS1 hom Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
0.231 5.70E-42 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p