HIPHOP chemogenomics database

YMR115W / MGR3

Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR115W / MGR3

Click on Significant Values for Screen Details

Top fitness defect scores for YMR115W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_769	0302-0231	13.60	76.0 µM	2.55E-45		1	1.34E-42
2	SGTC_2582	agaric acid	8.81	100.0 µM	4.60E-20	redox potentiating	86	6.40E-19
3	SGTC_2729	fluphenazine	5.34	10.7 µM	1.73E-8		1	4.64E-8
4	SGTC_1055	3448-0672	5.00	86.0 µM	1.20E-7		15	2.85E-7
5	SGTC_236	1509-0011	4.84	5.3 µM	2.82E-7		333	6.38E-7
6	SGTC_366	0181-0206	4.81	4.3 µM	3.37E-7	Golgi	19	7.53E-7
7	SGTC_2289	7946404	4.77	165.1 µM	4.07E-7		65	9.00E-7
8	SGTC_743	1275-0778	4.62	158.0 µM	8.90E-7	excess fatty acid	23	1.88E-6
9	SGTC_2126	5251174	4.07	33.9 µM	1.34E-5		29	2.40E-5
10	SGTC_2575	plumbagin	4.00	510.0 nM	1.79E-5	superoxide	38	3.15E-5
11	SGTC_908	3448-7491	3.91	47.7 µM	2.74E-5	mitochondrial stress	126	4.69E-5
12	SGTC_464	bw-b 70c	3.90	158.0 µM	2.80E-5		27	4.79E-5
13	SGTC_2489	cantharidin	3.87	73.4 µM	3.23E-5	cell wall signaling	46	5.49E-5
14	SGTC_794	k038-0031	3.85	316.0 µM	3.48E-5	ubiquinone biosynthesis & proteasome	110	5.88E-5
15	SGTC_163	1327-0036	3.84	7.5 µM	3.71E-5		111	6.25E-5
16	SGTC_795	0685-0265	3.79	78.0 µM	4.57E-5	excess fatty acid	32	7.59E-5
17	SGTC_811	0416-0114	3.76	265.0 µM	5.09E-5		31	8.41E-5
18	SGTC_2568	diosmetin	3.71	100.0 µM	6.38E-5		29	1.04E-4
19	SGTC_1353	1498-1206	3.70	8.1 µM	6.64E-5	mitochondrial response to ROS	62	1.08E-4
20	SGTC_3044	9093193	3.50	49.5 µM	1.52E-4		46	2.36E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.301	2.65E-71	YNL027W	CRZ1	hom	Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.265	3.14E-55	YER009W	NTF2	het	Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.230	2.05E-41	YCL044C	MGR1	hom	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.230	2.27E-41	YNL106C	INP52	hom	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.219	1.11E-37	YBR262C	AIM5	hom	Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.214	3.46E-36	YER172C	BRR2	het	RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.200	1.39E-31	YMR109W	MYO5	hom	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.197	1.45E-30	YML103C	NUP188	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.196	2.98E-30	YHR013C	ARD1	hom	Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress
0.193	1.78E-29	YOR050C_d	YOR050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.190	1.51E-28	YIL129C	TAO3	het	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.186	1.60E-27	YPR133W-A	TOM5	hom	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore
0.185	2.34E-27	YOR049C	RSB1	hom	Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.180	9.37E-26	YML052W	SUR7	hom	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.176	8.76E-25	YPL232W	SSO1	hom	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p