YMR130W_p

Putative protein of unknown function; YMR130W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR130W / YMR130W

Click on Significant Values for Screen Details ID:SGTC_645|Compound:0845-0943|FD-Score:2.66|P-value:8.79E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.67|P-value:8.37E-6 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.86|P-value:3.82E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.69|P-value:9.25E-6 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.43|P-value:3.52E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.01|P-value:2.00E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.93|P-value:5.12E-9 ID:SGTC_1523|Compound:st012844|FD-Score:3.98|P-value:1.52E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:2.98|P-value:2.31E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:5.50|P-value:5.91E-11 ID:SGTC_1571|Compound:st070080|FD-Score:2.67|P-value:8.46E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.39|P-value:3.45E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.29|P-value:5.60E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.17|P-value:9.78E-5 ID:SGTC_1913|Compound:st060213|FD-Score:-2.70|P-value:8.69E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.17|P-value:1.01E-4 ID:SGTC_2004|Compound:4023728|FD-Score:2.70|P-value:7.61E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.43|P-value:3.54E-5 ID:SGTC_2154|Compound:5570129|FD-Score:-2.69|P-value:9.12E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.92|P-value:2.15E-6 ID:SGTC_2324|Compound:6149169|FD-Score:2.67|P-value:8.35E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.29|P-value:5.58E-5 ID:SGTC_2348|Compound:9022543|FD-Score:2.63|P-value:9.81E-4 ID:SGTC_2350|Compound:9023895|FD-Score:2.70|P-value:7.63E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.08|P-value:1.52E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.82|P-value:5.39E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-2.68|P-value:9.50E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.99|P-value:2.23E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.70|P-value:1.83E-8 ID:SGTC_2868|Compound:9035608|FD-Score:-3.12|P-value:1.52E-4 ID:SGTC_2879|Compound:9041815|FD-Score:2.65|P-value:9.20E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.38|P-value:3.70E-5 ID:SGTC_3058|Compound:9093861|FD-Score:3.19|P-value:8.98E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.43|P-value:2.91E-5 ID:SGTC_3082|Compound:9117008|FD-Score:3.07|P-value:1.56E-4 ID:SGTC_3133|Compound:9127736|FD-Score:2.71|P-value:7.29E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-2.73|P-value:8.01E-4 ID:SGTC_3186|Compound:9110464|FD-Score:2.91|P-value:3.14E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:2.66|P-value:8.79E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.67|P-value:8.37E-6 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.86|P-value:3.82E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.69|P-value:9.25E-6 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.43|P-value:3.52E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.01|P-value:2.00E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.93|P-value:5.12E-9 ID:SGTC_1523|Compound:st012844|FD-Score:3.98|P-value:1.52E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:2.98|P-value:2.31E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:5.50|P-value:5.91E-11 ID:SGTC_1571|Compound:st070080|FD-Score:2.67|P-value:8.46E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.39|P-value:3.45E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.29|P-value:5.60E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.17|P-value:9.78E-5 ID:SGTC_1913|Compound:st060213|FD-Score:-2.70|P-value:8.69E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.17|P-value:1.01E-4 ID:SGTC_2004|Compound:4023728|FD-Score:2.70|P-value:7.61E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.43|P-value:3.54E-5 ID:SGTC_2154|Compound:5570129|FD-Score:-2.69|P-value:9.12E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.92|P-value:2.15E-6 ID:SGTC_2324|Compound:6149169|FD-Score:2.67|P-value:8.35E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.29|P-value:5.58E-5 ID:SGTC_2348|Compound:9022543|FD-Score:2.63|P-value:9.81E-4 ID:SGTC_2350|Compound:9023895|FD-Score:2.70|P-value:7.63E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.08|P-value:1.52E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.82|P-value:5.39E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-2.68|P-value:9.50E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.99|P-value:2.23E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.70|P-value:1.83E-8 ID:SGTC_2868|Compound:9035608|FD-Score:-3.12|P-value:1.52E-4 ID:SGTC_2879|Compound:9041815|FD-Score:2.65|P-value:9.20E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.38|P-value:3.70E-5 ID:SGTC_3058|Compound:9093861|FD-Score:3.19|P-value:8.98E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.43|P-value:2.91E-5 ID:SGTC_3082|Compound:9117008|FD-Score:3.07|P-value:1.56E-4 ID:SGTC_3133|Compound:9127736|FD-Score:2.71|P-value:7.29E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-2.73|P-value:8.01E-4 ID:SGTC_3186|Compound:9110464|FD-Score:2.91|P-value:3.14E-4

Top fitness defect scores for YMR130W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1570 verbenone 5.50 133.0 µM 5.91E-11 4 1.87E-8
2 SGTC_2798 7813637 4.70 45.5 µM 1.83E-8 17 1.30E-6
3 SGTC_1523 st012844 3.98 44.7 µM 1.52E-6 60S ribosome export 21 3.42E-5
4 SGTC_2288 7946289 3.92 167.3 µM 2.15E-6 28 4.43E-5
5 SGTC_1322 1348-1070 3.67 12.0 µM 8.37E-6 8 1.21E-4
6 SGTC_3061 glucosamine 3.43 200.0 µM 2.91E-5 19 3.06E-4
7 SGTC_1701 st028638 3.39 40.4 µM 3.45E-5 28 3.47E-4
8 SGTC_2991 9074669 3.38 71.4 µM 3.70E-5 azole & statin 94 3.66E-4
9 SGTC_2327 6189656 3.29 200.0 µM 5.58E-5 45 4.97E-4
10 SGTC_1739 st037196 3.29 92.5 µM 5.60E-5 49 4.98E-4
11 SGTC_3058 9093861 3.19 49.5 µM 8.98E-5 47 7.07E-4
12 SGTC_1815 st051655 3.17 58.2 µM 9.78E-5 TSC3-RPN4 27 7.54E-4
13 SGTC_1996 st072960 3.17 66.8 µM 1.01E-4 45 7.73E-4
14 SGTC_2563 tomatine 3.08 8.5 µM 1.52E-4 99 0.00105
15 SGTC_3082 9117008 3.07 49.5 µM 1.56E-4 48 0.00107
16 SGTC_1395 3486-0190 3.01 4.3 µM 2.00E-4 55 0.00129
17 SGTC_2757 clomiphene 2.99 4.2 µM 2.23E-4 fatty acid desaturase (OLE1) 95 0.00139
18 SGTC_1568 digitonin 2.98 820.0 nM 2.31E-4 sphingolipid biosynthesis & PDR1 71 0.00143
19 SGTC_3186 9110464 2.91 49.5 µM 3.14E-4 RPP1 & pyrimidine depletion 44 0.00180
20 SGTC_1383 3049-0032 2.86 20.7 µM 3.82E-4 60S ribosome export 63 0.00209

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 1.01E-16 YOL032W OPI10 hom Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.141 1.75E-16 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.134 6.52E-15 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.124 5.34E-13 YPL119C-A_p YPL119C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.119 4.03E-12 YMR255W GFD1 hom Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress
0.117 1.19E-11 YKL108W SLD2 het Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress
0.102 3.37E-9 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
0.096 2.93E-8 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.094 4.38E-8 YNL130C-A_p DGR1_p hom Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose
0.093 5.84E-8 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.092 9.55E-8 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.090 1.81E-7 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.089 2.23E-7 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.089 2.77E-7 YCL049C_p YCL049C_p hom Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene
0.088 2.96E-7 YNL197C WHI3 hom RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication