YMR135W-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR135W-A / YMR135W-A

Click on Significant Values for Screen Details ID:SGTC_349|Compound:k015-0014|FD-Score:3.27|P-value:1.10E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:2.86|P-value:6.09E-4 ID:SGTC_389|Compound:tpck|FD-Score:2.85|P-value:6.46E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.50|P-value:3.86E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.25|P-value:1.58E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.18|P-value:2.19E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.90|P-value:7.59E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:3.74|P-value:1.22E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-2.96|P-value:5.40E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.04|P-value:3.89E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-2.81|P-value:9.53E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.05|P-value:2.90E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.27|P-value:1.45E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-2.87|P-value:7.71E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.59|P-value:2.53E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.32|P-value:1.22E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:-2.96|P-value:5.44E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.84|P-value:8.36E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.30|P-value:9.59E-5 ID:SGTC_1638|Compound:st008370|FD-Score:-3.08|P-value:3.25E-4 ID:SGTC_1827|Compound:berberine|FD-Score:2.99|P-value:3.57E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.23|P-value:1.77E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.69|P-value:2.21E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-2.96|P-value:5.32E-4 ID:SGTC_2242|Compound:6630449|FD-Score:2.74|P-value:9.66E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.70|P-value:2.11E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-3.99|P-value:4.90E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.87|P-value:8.92E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-2.85|P-value:8.20E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:2.96|P-value:4.08E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.14|P-value:1.93E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.64|P-value:2.77E-5 ID:SGTC_2946|Compound:9065502|FD-Score:-2.86|P-value:8.00E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.15|P-value:2.50E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.77|P-value:1.45E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-2.83|P-value:8.70E-4 ID:SGTC_3040|Compound:9091894|FD-Score:-3.55|P-value:4.23E-5 ID:SGTC_3135|Compound:9127742|FD-Score:2.77|P-value:8.68E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.10|P-value:2.98E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.81|P-value:9.65E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.07|P-value:2.66E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.57|P-value:3.82E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-4.08|P-value:3.09E-6 ID:SGTC_349|Compound:k015-0014|FD-Score:3.27|P-value:1.10E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:2.86|P-value:6.09E-4 ID:SGTC_389|Compound:tpck|FD-Score:2.85|P-value:6.46E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.50|P-value:3.86E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.25|P-value:1.58E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.18|P-value:2.19E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.90|P-value:7.59E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:3.74|P-value:1.22E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-2.96|P-value:5.40E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.04|P-value:3.89E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-2.81|P-value:9.53E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.05|P-value:2.90E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.27|P-value:1.45E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-2.87|P-value:7.71E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.59|P-value:2.53E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.32|P-value:1.22E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:-2.96|P-value:5.44E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.84|P-value:8.36E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.30|P-value:9.59E-5 ID:SGTC_1638|Compound:st008370|FD-Score:-3.08|P-value:3.25E-4 ID:SGTC_1827|Compound:berberine|FD-Score:2.99|P-value:3.57E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.23|P-value:1.77E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.69|P-value:2.21E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-2.96|P-value:5.32E-4 ID:SGTC_2242|Compound:6630449|FD-Score:2.74|P-value:9.66E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.70|P-value:2.11E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-3.99|P-value:4.90E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.87|P-value:8.92E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-2.85|P-value:8.20E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:2.96|P-value:4.08E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.14|P-value:1.93E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.64|P-value:2.77E-5 ID:SGTC_2946|Compound:9065502|FD-Score:-2.86|P-value:8.00E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.15|P-value:2.50E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.77|P-value:1.45E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-2.83|P-value:8.70E-4 ID:SGTC_3040|Compound:9091894|FD-Score:-3.55|P-value:4.23E-5 ID:SGTC_3135|Compound:9127742|FD-Score:2.77|P-value:8.68E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.10|P-value:2.98E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.81|P-value:9.65E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.07|P-value:2.66E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.57|P-value:3.82E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-4.08|P-value:3.09E-6

Top fitness defect scores for YMR135W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_757 1066-0008 3.74 322.0 µM 1.22E-5 Golgi 23 9.12E-5
2 SGTC_1355 1499-0035 3.59 1.7 µM 2.53E-5 28 1.64E-4
3 SGTC_423 5-fluorouracil 3.50 457.0 µM 3.86E-5 exosome 37 2.30E-4
4 SGTC_1464 k208-0027 3.30 110.0 µM 9.59E-5 41 4.78E-4
5 SGTC_349 k015-0014 3.27 24.0 µM 1.10E-4 45 5.32E-4
6 SGTC_2806 7952793 3.14 58.4 µM 1.93E-4 56 8.41E-4
7 SGTC_3325 9138760 3.07 55.2 µM 2.66E-4 Golgi 54 0.00109
8 SGTC_1058 3448-5425 3.05 97.3 µM 2.90E-4 61 0.00116
9 SGTC_1827 berberine 2.99 7.2 µM 3.57E-4 60S ribosome export 61 0.00138
10 SGTC_2546 rhodinyl acetate 2.96 100.0 µM 4.08E-4 47 0.00153
11 SGTC_355 1311-2252 2.86 105.0 µM 6.09E-4 75 0.00212
12 SGTC_389 tpck 2.85 16.7 µM 6.46E-4 78 0.00222
13 SGTC_3135 9127742 2.77 49.5 µM 8.68E-4 65 0.00282
14 SGTC_2242 6630449 2.74 61.3 µM 9.66E-4 Golgi 105 0.00307
15 SGTC_3038 9091290 2.69 49.5 µM 0.00117 79 0.00357
16 SGTC_1895 st058434 2.68 18.3 µM 0.00121 75 0.00367
17 SGTC_670 4204-0025 2.67 119.0 µM 0.00125 copper-dependent oxidative stress 102 0.00379
18 SGTC_1557 sumaresinolic acid 2.66 42.3 µM 0.00129 86 0.00389
19 SGTC_369 0957-0393 2.66 4.5 µM 0.00131 cell wall signaling 98 0.00391
20 SGTC_1833 st055984 2.61 71.0 µM 0.00155 88 0.00449

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.67E-16 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.136 2.96E-15 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.134 5.54E-15 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.132 1.63E-14 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.132 2.10E-14 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.131 3.08E-14 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.131 3.17E-14 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.129 6.65E-14 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.127 1.39E-13 YNL301C RPL18B hom Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication
0.127 1.67E-13 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.121 1.85E-12 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.118 6.97E-12 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.116 1.77E-11 YDR036C EHD3 hom 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
0.115 2.63E-11 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.113 5.33E-11 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data