HIPHOP chemogenomics database
YMR152W / YIM1 
Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YMR152W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.358 | 4.41E-102 | YJR142W_p | YJR142W_p | hom | Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member |
| 0.340 | 1.27E-91 | YJR054W | KCH1 | hom | Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate |
| 0.331 | 8.25E-87 | YNL314W | DAL82 | hom | Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain |
| 0.327 | 1.11E-84 | YCL005W | LDB16 | hom | Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria |
| 0.325 | 1.55E-83 | YDL066W | IDP1 | hom | Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes |
| 0.320 | 9.12E-81 | YPL115C | BEM3 | hom | Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly |
| 0.320 | 1.88E-80 | YJL099W | CHS6 | hom | Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication |
| 0.315 | 2.18E-78 | YBL006C | LDB7 | hom | Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions |
| 0.311 | 5.58E-76 | YKL033W-A_p | YKL033W-A_p | hom | Putative protein of unknown function; similar to uncharacterized proteins from other fungi |
| 0.310 | 1.54E-75 | YLL032C | YLL032C | hom | Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene |
| 0.309 | 3.23E-75 | YMR124W_p | YMR124W_p | hom | Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization |
| 0.309 | 5.06E-75 | YBR023C | CHS3 | hom | Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan |
| 0.300 | 7.47E-71 | YDL203C | ACK1 | hom | Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria |
| 0.300 | 1.12E-70 | YKL076C_d | PSY1_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C |
| 0.288 | 3.84E-65 | YOL003C | PFA4 | hom | Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases |