YMR158W-B_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR158W-B / YMR158W-B

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.89|P-value:2.06E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-4.30|P-value:4.00E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.08|P-value:7.23E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.51|P-value:1.06E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:4.61|P-value:6.07E-7 ID:SGTC_357|Compound:1325-0123|FD-Score:-4.53|P-value:1.24E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.24|P-value:5.32E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.85|P-value:2.35E-7 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.44|P-value:1.40E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.20|P-value:3.66E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:2.93|P-value:9.82E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.10|P-value:6.72E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.07|P-value:7.39E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.11|P-value:6.41E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-3.06|P-value:7.75E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.91|P-value:1.82E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.17|P-value:4.02E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.75|P-value:3.86E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.07|P-value:5.77E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.10|P-value:5.28E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.31|P-value:2.31E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.10|P-value:5.31E-4 ID:SGTC_1828|Compound:st055811|FD-Score:4.26|P-value:3.62E-6 ID:SGTC_1937|Compound:st074714|FD-Score:3.19|P-value:3.78E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_2114|Compound:5491910|FD-Score:4.08|P-value:8.56E-6 ID:SGTC_2117|Compound:5521686|FD-Score:-3.88|P-value:2.87E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.10|P-value:5.20E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-4.65|P-value:6.70E-7 ID:SGTC_2286|Compound:7945697|FD-Score:4.22|P-value:4.31E-6 ID:SGTC_2289|Compound:7946404|FD-Score:4.70|P-value:3.66E-7 ID:SGTC_2320|Compound:7373003|FD-Score:-3.64|P-value:8.11E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.40|P-value:1.62E-4 ID:SGTC_2329|Compound:6138490|FD-Score:6.44|P-value:6.52E-12 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.39|P-value:1.75E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.81|P-value:2.92E-5 ID:SGTC_3304|Compound:9125678|FD-Score:-3.54|P-value:1.23E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.25|P-value:2.92E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.87|P-value:3.02E-5 ID:SGTC_24|Compound:0417-1663|FD-Score:3.89|P-value:2.06E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-4.30|P-value:4.00E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.08|P-value:7.23E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.51|P-value:1.06E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:4.61|P-value:6.07E-7 ID:SGTC_357|Compound:1325-0123|FD-Score:-4.53|P-value:1.24E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.24|P-value:5.32E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.85|P-value:2.35E-7 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.44|P-value:1.40E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.20|P-value:3.66E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:2.93|P-value:9.82E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.10|P-value:6.72E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.07|P-value:7.39E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.11|P-value:6.41E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-3.06|P-value:7.75E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.91|P-value:1.82E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.17|P-value:4.02E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.75|P-value:3.86E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.07|P-value:5.77E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.10|P-value:5.28E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.31|P-value:2.31E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.10|P-value:5.31E-4 ID:SGTC_1828|Compound:st055811|FD-Score:4.26|P-value:3.62E-6 ID:SGTC_1937|Compound:st074714|FD-Score:3.19|P-value:3.78E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_2114|Compound:5491910|FD-Score:4.08|P-value:8.56E-6 ID:SGTC_2117|Compound:5521686|FD-Score:-3.88|P-value:2.87E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.10|P-value:5.20E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-4.65|P-value:6.70E-7 ID:SGTC_2286|Compound:7945697|FD-Score:4.22|P-value:4.31E-6 ID:SGTC_2289|Compound:7946404|FD-Score:4.70|P-value:3.66E-7 ID:SGTC_2320|Compound:7373003|FD-Score:-3.64|P-value:8.11E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.40|P-value:1.62E-4 ID:SGTC_2329|Compound:6138490|FD-Score:6.44|P-value:6.52E-12 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.39|P-value:1.75E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.81|P-value:2.92E-5 ID:SGTC_3304|Compound:9125678|FD-Score:-3.54|P-value:1.23E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.25|P-value:2.92E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.87|P-value:3.02E-5

Top fitness defect scores for YMR158W-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2329 6138490 6.44 200.0 µM 6.52E-12 6 6.08E-11
2 SGTC_2289 7946404 4.70 165.1 µM 3.66E-7 68 1.29E-6
3 SGTC_342 k048-0088 4.61 23.3 µM 6.07E-7 RSC & ERG11 8 2.04E-6
4 SGTC_1828 st055811 4.26 49.0 µM 3.62E-6 5 1.04E-5
5 SGTC_2286 7945697 4.22 125.0 µM 4.31E-6 45 1.22E-5
6 SGTC_2114 5491910 4.08 81.2 µM 8.56E-6 7 2.28E-5
7 SGTC_1136 pergolide 3.91 1.1 µM 1.82E-5 41 4.52E-5
8 SGTC_24 0417-1663 3.89 219.0 µM 2.06E-5 19 5.06E-5
9 SGTC_2485 5633444 3.81 17.8 µM 2.92E-5 redox potentiating 50 6.95E-5
10 SGTC_1340 1486-1359 3.75 257.0 µM 3.86E-5 26 8.97E-5
11 SGTC_2012 4023501 3.52 200.0 µM 1.02E-4 49 2.17E-4
12 SGTC_185 k048-0037 3.51 25.5 µM 1.06E-4 RSC & ERG11 17 2.24E-4
13 SGTC_390 dec-rvkr-cmk 3.44 16.7 µM 1.40E-4 calcium & mitochondrial duress 48 2.90E-4
14 SGTC_2321 7390090 3.40 138.8 µM 1.62E-4 49 3.31E-4
15 SGTC_2418 pentamidine 3.39 31.7 µM 1.75E-4 mitochondrial processes 70 3.55E-4
16 SGTC_1653 st012112 3.31 65.0 µM 2.31E-4 30 4.59E-4
17 SGTC_3310 9130229 3.25 44.1 µM 2.92E-4 Golgi 55 5.67E-4
18 SGTC_500 h-89 3.20 112.0 µM 3.66E-4 cell wall signaling 59 6.97E-4
19 SGTC_1937 st074714 3.19 47.2 µM 3.78E-4 67 7.16E-4
20 SGTC_1192 1488-0095 3.17 21.4 µM 4.02E-4 42 7.58E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.98E-16 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.126 3.08E-13 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.113 4.38E-11 YAL027W SAW1 hom 5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.104 1.43E-9 YDL117W CYK3 hom SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
0.096 2.63E-8 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.095 3.89E-8 YGL048C RPT6 het ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress
0.094 4.53E-8 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.093 5.81E-8 YOR177C MPC54 hom Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
0.090 1.73E-7 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.089 2.14E-7 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.088 3.55E-7 YBL074C AAR2 het Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
0.087 4.21E-7 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.087 4.83E-7 YGL157W ARI1 hom NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily
0.085 7.15E-7 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.085 8.00E-7 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall