YMR167W / MLH1

Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR167W / MLH1

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.11|P-value:2.81E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.46|P-value:3.89E-7 ID:SGTC_164|Compound:4100-3994|FD-Score:4.07|P-value:3.17E-6 ID:SGTC_456|Compound:gingerol|FD-Score:4.31|P-value:9.08E-7 ID:SGTC_542|Compound:3381-0244|FD-Score:3.22|P-value:1.79E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:-3.69|P-value:2.42E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.09|P-value:3.37E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.44|P-value:6.75E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-2.99|P-value:5.04E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:2.90|P-value:6.58E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-4.12|P-value:2.84E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:-4.16|P-value:2.21E-6 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.10|P-value:2.93E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.49|P-value:5.50E-5 ID:SGTC_1647|Compound:st011722|FD-Score:2.83|P-value:8.52E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.41|P-value:7.89E-5 ID:SGTC_1871|Compound:st057448|FD-Score:-2.90|P-value:6.92E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-4.51|P-value:3.26E-7 ID:SGTC_2030|Compound:5175110|FD-Score:-3.42|P-value:8.24E-5 ID:SGTC_2060|Compound:5238662|FD-Score:2.85|P-value:7.85E-4 ID:SGTC_2268|Compound:7933382|FD-Score:5.20|P-value:4.14E-9 ID:SGTC_2350|Compound:9023895|FD-Score:-2.93|P-value:6.35E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.97|P-value:4.95E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.42|P-value:7.59E-5 ID:SGTC_2471|Compound:5466956|FD-Score:-3.43|P-value:7.92E-5 ID:SGTC_2473|Compound:5854593|FD-Score:3.66|P-value:2.46E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.09|P-value:3.28E-4 ID:SGTC_2525|Compound:harmine|FD-Score:4.27|P-value:1.10E-6 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.46|P-value:7.03E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.96|P-value:5.69E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.41|P-value:7.83E-5 ID:SGTC_2784|Compound:7567673|FD-Score:2.90|P-value:6.50E-4 ID:SGTC_2792|Compound:7535235|FD-Score:2.84|P-value:8.17E-4 ID:SGTC_2940|Compound:9060638|FD-Score:2.80|P-value:9.57E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.50|P-value:5.14E-5 ID:SGTC_2982|Compound:9019404|FD-Score:2.82|P-value:8.64E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.88|P-value:8.44E-6 ID:SGTC_2988|Compound:9073640|FD-Score:-4.24|P-value:1.46E-6 ID:SGTC_2994|Compound:9053520|FD-Score:3.35|P-value:1.01E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.55|P-value:2.34E-7 ID:SGTC_3221|Compound:9128209|FD-Score:-3.38|P-value:1.00E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.07|P-value:3.37E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.11|P-value:2.81E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.46|P-value:3.89E-7 ID:SGTC_164|Compound:4100-3994|FD-Score:4.07|P-value:3.17E-6 ID:SGTC_456|Compound:gingerol|FD-Score:4.31|P-value:9.08E-7 ID:SGTC_542|Compound:3381-0244|FD-Score:3.22|P-value:1.79E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:-3.69|P-value:2.42E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.09|P-value:3.37E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.44|P-value:6.75E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-2.99|P-value:5.04E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:2.90|P-value:6.58E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-4.12|P-value:2.84E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:-4.16|P-value:2.21E-6 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.10|P-value:2.93E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.49|P-value:5.50E-5 ID:SGTC_1647|Compound:st011722|FD-Score:2.83|P-value:8.52E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.41|P-value:7.89E-5 ID:SGTC_1871|Compound:st057448|FD-Score:-2.90|P-value:6.92E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-4.51|P-value:3.26E-7 ID:SGTC_2030|Compound:5175110|FD-Score:-3.42|P-value:8.24E-5 ID:SGTC_2060|Compound:5238662|FD-Score:2.85|P-value:7.85E-4 ID:SGTC_2268|Compound:7933382|FD-Score:5.20|P-value:4.14E-9 ID:SGTC_2350|Compound:9023895|FD-Score:-2.93|P-value:6.35E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.97|P-value:4.95E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.42|P-value:7.59E-5 ID:SGTC_2471|Compound:5466956|FD-Score:-3.43|P-value:7.92E-5 ID:SGTC_2473|Compound:5854593|FD-Score:3.66|P-value:2.46E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.09|P-value:3.28E-4 ID:SGTC_2525|Compound:harmine|FD-Score:4.27|P-value:1.10E-6 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.46|P-value:7.03E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.96|P-value:5.69E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.41|P-value:7.83E-5 ID:SGTC_2784|Compound:7567673|FD-Score:2.90|P-value:6.50E-4 ID:SGTC_2792|Compound:7535235|FD-Score:2.84|P-value:8.17E-4 ID:SGTC_2940|Compound:9060638|FD-Score:2.80|P-value:9.57E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.50|P-value:5.14E-5 ID:SGTC_2982|Compound:9019404|FD-Score:2.82|P-value:8.64E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.88|P-value:8.44E-6 ID:SGTC_2988|Compound:9073640|FD-Score:-4.24|P-value:1.46E-6 ID:SGTC_2994|Compound:9053520|FD-Score:3.35|P-value:1.01E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.55|P-value:2.34E-7 ID:SGTC_3221|Compound:9128209|FD-Score:-3.38|P-value:1.00E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.07|P-value:3.37E-4

Top fitness defect scores for YMR167W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2268 7933382 5.20 153.8 µM 4.14E-9 16 9.79E-8
2 SGTC_3217 9129673 4.55 49.5 µM 2.34E-7 20 2.70E-6
3 SGTC_42 0133-0086 4.46 60.6 µM 3.89E-7 15 4.10E-6
4 SGTC_456 gingerol 4.31 170.0 µM 9.08E-7 12 8.25E-6
5 SGTC_2525 harmine 4.27 47.9 µM 1.10E-6 ergosterol biosynthesis 9 9.65E-6
6 SGTC_164 4100-3994 4.07 89.6 µM 3.17E-6 27 2.31E-5
7 SGTC_2986 9022445 3.88 71.4 µM 8.44E-6 17 5.17E-5
8 SGTC_2473 5854593 3.66 8.9 µM 2.46E-5 18 1.25E-4
9 SGTC_2962 9082311 3.50 13.2 µM 5.14E-5 35 2.30E-4
10 SGTC_1371 2421-0008 3.49 32.7 µM 5.50E-5 mitochondrial processes 62 2.43E-4
11 SGTC_1076 itraconazole 3.44 331.0 nM 6.75E-5 52 2.88E-4
12 SGTC_2463 5473429 3.42 200.0 µM 7.59E-5 ERG2 29 3.17E-4
13 SGTC_2643 anethole 3.41 100.0 µM 7.83E-5 31 3.25E-4
14 SGTC_1681 tripelennamine 3.41 100.0 µM 7.89E-5 34 3.27E-4
15 SGTC_2994 9053520 3.35 71.4 µM 1.01E-4 RPP1 & pyrimidine depletion 40 4.01E-4
16 SGTC_542 3381-0244 3.22 89.3 µM 1.79E-4 73 6.43E-4
17 SGTC_24 0417-1663 3.11 219.0 µM 2.81E-4 49 9.36E-4
18 SGTC_1275 0867-0008 3.10 21.1 µM 2.93E-4 40 9.69E-4
19 SGTC_3338 9144300 3.07 39.6 µM 3.37E-4 Golgi 57 0.00109
20 SGTC_2410 aloe-emodin-8-o-glycoside 2.97 46.3 µM 4.95E-4 mitochondrial processes 85 0.00149

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 8.21E-11 YBR092C PHO3 hom Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
0.109 2.48E-10 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.098 1.16E-8 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.090 1.71E-7 YKL017C HCS1 hom Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
0.090 1.84E-7 YCL025C AGP1 hom Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication
0.080 3.05E-6 YGR203W YCH1 hom Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.079 4.19E-6 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.075 1.31E-5 YER134C YER134C hom Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene
0.075 1.48E-5 YHR081W LRP1 hom Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
0.071 3.93E-5 YJR126C VPS70 hom Protein of unknown function involved in vacuolar protein sorting
0.069 6.05E-5 YHL007C STE20 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
0.069 7.01E-5 YIR024C YIR024C hom Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect
0.068 8.08E-5 YER168C CCA1 het ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
0.068 8.11E-5 YBL083C_d YBL083C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3
0.068 8.46E-5 YIL062C ARC15 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity