YMR180C / CTL1

RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR180C / CTL1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.87|P-value:1.69E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.82|P-value:2.07E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.94|P-value:1.18E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:2.92|P-value:8.81E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-4.27|P-value:2.24E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.32|P-value:1.82E-4 ID:SGTC_417|Compound:st075190|FD-Score:4.34|P-value:1.60E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:4.04|P-value:7.46E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:-3.21|P-value:2.80E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.10|P-value:4.52E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.32|P-value:1.90E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-4.05|P-value:6.87E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.96|P-value:7.49E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.17|P-value:3.41E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.35|P-value:1.65E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.06|P-value:5.12E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.31|P-value:1.89E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.09|P-value:4.69E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:2.88|P-value:9.99E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.58|P-value:6.17E-5 ID:SGTC_1646|Compound:st011709|FD-Score:3.38|P-value:1.43E-4 ID:SGTC_1759|Compound:st043059|FD-Score:-3.24|P-value:2.53E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.36|P-value:1.55E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.19|P-value:3.12E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.09|P-value:4.52E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.11|P-value:4.35E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:2.93|P-value:8.58E-4 ID:SGTC_2343|Compound:7990716|FD-Score:5.03|P-value:3.56E-8 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.93|P-value:6.19E-8 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.02|P-value:5.91E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.89|P-value:7.75E-8 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.92|P-value:1.33E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.66|P-value:4.32E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:2.89|P-value:9.79E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.59|P-value:6.06E-5 ID:SGTC_2881|Compound:9058953|FD-Score:3.72|P-value:3.33E-5 ID:SGTC_2952|Compound:9073731|FD-Score:-3.32|P-value:1.85E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.63|P-value:4.86E-5 ID:SGTC_3071|Compound:9117417|FD-Score:-3.20|P-value:2.99E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-4.52|P-value:6.13E-7 ID:SGTC_3137|Compound:9097352|FD-Score:2.89|P-value:9.85E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.83|P-value:1.96E-5 ID:SGTC_3214|Compound:9129694|FD-Score:5.72|P-value:4.40E-10 ID:SGTC_3248|Compound:9135562|FD-Score:-3.71|P-value:3.37E-5 ID:SGTC_3334|Compound:9142812|FD-Score:4.18|P-value:3.70E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:3.87|P-value:1.69E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.82|P-value:2.07E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.94|P-value:1.18E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:2.92|P-value:8.81E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-4.27|P-value:2.24E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.32|P-value:1.82E-4 ID:SGTC_417|Compound:st075190|FD-Score:4.34|P-value:1.60E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:4.04|P-value:7.46E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:-3.21|P-value:2.80E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.10|P-value:4.52E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.32|P-value:1.90E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-4.05|P-value:6.87E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.96|P-value:7.49E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.17|P-value:3.41E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.35|P-value:1.65E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.06|P-value:5.12E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.31|P-value:1.89E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.09|P-value:4.69E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:2.88|P-value:9.99E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.58|P-value:6.17E-5 ID:SGTC_1646|Compound:st011709|FD-Score:3.38|P-value:1.43E-4 ID:SGTC_1759|Compound:st043059|FD-Score:-3.24|P-value:2.53E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.36|P-value:1.55E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.19|P-value:3.12E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.09|P-value:4.52E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.11|P-value:4.35E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:2.93|P-value:8.58E-4 ID:SGTC_2343|Compound:7990716|FD-Score:5.03|P-value:3.56E-8 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.93|P-value:6.19E-8 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.02|P-value:5.91E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.89|P-value:7.75E-8 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.92|P-value:1.33E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.66|P-value:4.32E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:2.89|P-value:9.79E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.59|P-value:6.06E-5 ID:SGTC_2881|Compound:9058953|FD-Score:3.72|P-value:3.33E-5 ID:SGTC_2952|Compound:9073731|FD-Score:-3.32|P-value:1.85E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.63|P-value:4.86E-5 ID:SGTC_3071|Compound:9117417|FD-Score:-3.20|P-value:2.99E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-4.52|P-value:6.13E-7 ID:SGTC_3137|Compound:9097352|FD-Score:2.89|P-value:9.85E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.83|P-value:1.96E-5 ID:SGTC_3214|Compound:9129694|FD-Score:5.72|P-value:4.40E-10 ID:SGTC_3248|Compound:9135562|FD-Score:-3.71|P-value:3.37E-5 ID:SGTC_3334|Compound:9142812|FD-Score:4.18|P-value:3.70E-6

Top fitness defect scores for YMR180C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3214 9129694 5.72 49.5 µM 4.40E-10 5 5.42E-9
2 SGTC_2343 7990716 5.03 14.8 µM 3.56E-8 5 2.51E-7
3 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.93 3.7 µM 6.19E-8 33 4.07E-7
4 SGTC_2610 ononetin 4.89 44.2 µM 7.75E-8 18 4.95E-7
5 SGTC_417 st075190 4.34 100.0 µM 1.60E-6 4 6.98E-6
6 SGTC_3334 9142812 4.18 21.9 µM 3.70E-6 25 1.45E-5
7 SGTC_696 1560-0013 4.04 611.0 µM 7.46E-6 19 2.68E-5
8 SGTC_2613 3',4'-dimethoxydalbergione 3.92 24.6 µM 1.33E-5 25 4.46E-5
9 SGTC_6 0844-0013 3.87 19.8 µM 1.69E-5 95 5.48E-5
10 SGTC_2881 9058953 3.72 52.0 µM 3.33E-5 31 9.94E-5
11 SGTC_2833 9001315 3.59 45.5 µM 6.06E-5 amide catabolism 70 1.68E-4
12 SGTC_1642 st009582 3.58 77.7 µM 6.17E-5 RPP1 & pyrimidine depletion 23 1.71E-4
13 SGTC_1646 st011709 3.38 75.6 µM 1.43E-4 26 3.56E-4
14 SGTC_1820 st053765 3.36 18.6 µM 1.55E-4 RPP1 & pyrimidine depletion 36 3.84E-4
15 SGTC_1426 4048-4480 3.35 71.7 µM 1.65E-4 60S ribosome export 33 4.04E-4
16 SGTC_824 1304-0008 3.32 100.0 µM 1.90E-4 DNA damage response 60 4.57E-4
17 SGTC_1963 st076565 3.19 50.3 µM 3.12E-4 40 7.07E-4
18 SGTC_1379 2144-0755 3.17 36.5 µM 3.41E-4 47 7.64E-4
19 SGTC_2156 5649887 3.11 115.0 µM 4.35E-4 RPP1 & pyrimidine depletion 46 9.46E-4
20 SGTC_724 3910-0327 3.10 137.0 µM 4.52E-4 ERG2 54 9.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.79E-25 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.170 2.86E-23 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.120 2.50E-12 YJR024C MDE1 hom 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant
0.114 3.74E-11 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.111 1.23E-10 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.110 1.78E-10 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.108 3.77E-10 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.104 1.40E-9 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.104 1.53E-9 YGR259C_d YGR259C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
0.103 1.88E-9 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.102 2.76E-9 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.101 4.18E-9 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.101 5.10E-9 YMR145C NDE1 hom Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
0.100 5.91E-9 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.100 6.46E-9 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities