YMR181C_p

Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR181C / YMR181C

Click on Significant Values for Screen Details ID:SGTC_296|Compound:1222-0039|FD-Score:3.23|P-value:4.92E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.65|P-value:1.09E-6 ID:SGTC_376|Compound:3970-0862|FD-Score:3.87|P-value:3.96E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.61|P-value:1.16E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.12|P-value:7.32E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.17|P-value:6.05E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.58|P-value:1.29E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.18|P-value:1.01E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.57|P-value:1.34E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.15|P-value:1.15E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.78|P-value:5.66E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.20|P-value:5.50E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.93|P-value:3.03E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-4.16|P-value:1.14E-5 ID:SGTC_1736|Compound:st036774|FD-Score:4.11|P-value:1.37E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.64|P-value:1.12E-6 ID:SGTC_2168|Compound:5727979|FD-Score:-3.45|P-value:2.21E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.17|P-value:6.02E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.10|P-value:7.74E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.58|P-value:1.33E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.23|P-value:4.92E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.65|P-value:1.09E-6 ID:SGTC_376|Compound:3970-0862|FD-Score:3.87|P-value:3.96E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.61|P-value:1.16E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.12|P-value:7.32E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.17|P-value:6.05E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.58|P-value:1.29E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.18|P-value:1.01E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.57|P-value:1.34E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.15|P-value:1.15E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.78|P-value:5.66E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.20|P-value:5.50E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.93|P-value:3.03E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-4.16|P-value:1.14E-5 ID:SGTC_1736|Compound:st036774|FD-Score:4.11|P-value:1.37E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.64|P-value:1.12E-6 ID:SGTC_2168|Compound:5727979|FD-Score:-3.45|P-value:2.21E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.17|P-value:6.02E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.10|P-value:7.74E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.58|P-value:1.33E-4

Top fitness defect scores for YMR181C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1926 methyl fluorone black 4.64 53.6 µM 1.12E-6 DNA intercalators 43 1.75E-6
2 SGTC_994 3910-0338 4.18 138.0 µM 1.01E-5 calcium & mitochondrial duress 41 1.46E-5
3 SGTC_1214 0358-0031 4.15 63.7 µM 1.15E-5 10 1.66E-5
4 SGTC_1736 st036774 4.11 51.0 µM 1.37E-5 27 1.97E-5
5 SGTC_1676 st018489 3.93 23.4 µM 3.03E-5 60S ribosome export 36 4.21E-5
6 SGTC_376 3970-0862 3.87 59.1 µM 3.96E-5 21 5.46E-5
7 SGTC_1249 0481-0015 3.78 10.2 µM 5.66E-5 29 7.70E-5
8 SGTC_382 3229-0966 3.61 23.2 µM 1.16E-4 35 1.53E-4
9 SGTC_552 k242-0005 3.58 476.0 µM 1.29E-4 28 1.70E-4
10 SGTC_1203 3992-3522 3.57 103.0 µM 1.34E-4 52 1.76E-4
11 SGTC_296 1222-0039 3.23 74.9 µM 4.92E-4 34 6.19E-4
12 SGTC_1579 chlormadinone acetate 3.20 49.4 µM 5.50E-4 33 6.88E-4
13 SGTC_2375 9072683 3.17 200.0 µM 6.02E-4 mitochondrial processes 48 7.52E-4
14 SGTC_431 k089-0097 3.17 107.0 µM 6.05E-4 iron homeostasis 84 7.56E-4
15 SGTC_2581 avocatin a 3.10 64.0 µM 7.74E-4 sphingolipid biosynthesis & PDR1 88 9.58E-4
16 SGTC_2115 tiliquinol 2.98 12.8 µM 0.00116 35 0.00142
17 SGTC_2066 5222451 2.98 176.0 µM 0.00117 heme biosynthesis & mitochondrial translocase 89 0.00142
18 SGTC_742 0kpi-0133 2.98 140.0 µM 0.00119 ERG2 59 0.00145
19 SGTC_2252 omeprazole 2.97 400.0 µM 0.00121 29 0.00147
20 SGTC_854 0422-0053 2.95 192.0 µM 0.00131 PDR1 48 0.00159

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 8.42E-14 YER099C PRS2 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
0.114 3.00E-11 YGR179C OKP1 het Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7
0.113 5.77E-11 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.109 2.05E-10 YLR419W_p YLR419W_p hom Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene
0.108 4.14E-10 YKL137W CMC1 hom Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
0.106 7.11E-10 YPL186C UIP4 hom Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
0.103 2.27E-9 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.101 4.72E-9 YJL065C DLS1 hom Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication
0.091 1.21E-7 YPL165C SET6 hom SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
0.090 1.80E-7 YBR056W YBR056W hom Putative glycoside hydrolase of the mitochondrial intermembrane space
0.088 3.85E-7 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.086 5.85E-7 YOR154W_p SLP1_p hom Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p
0.086 6.60E-7 YPL175W SPT14 het UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
0.085 8.56E-7 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.085 8.81E-7 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase