HIPHOP chemogenomics database

YMR182W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR182W-A / YMR182W-A

Click on Significant Values for Screen Details

Top fitness defect scores for YMR182W-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2831	7999036	14.90	19.5 µM	1.42E-64		1	2.25E-50
2	SGTC_695	3505-6186	5.19	243.0 µM	1.65E-9		9	1.06E-7
3	SGTC_2835	9006588	5.16	71.4 µM	2.07E-9		16	1.26E-7
4	SGTC_2794	7785382	4.71	27.3 µM	3.98E-8		13	1.26E-6
5	SGTC_1741	st038134	4.11	10.2 µM	1.39E-6		27	2.00E-5
6	SGTC_2209	5-(5-methyl-2-thenylidene)-Barbituric acid	3.92	122.8 µM	3.78E-6		10	4.37E-5
7	SGTC_2724	maprotiline	3.57	69.6 µM	2.33E-5	ERG2	22	1.81E-4
8	SGTC_1331	1472-0049	3.54	76.2 µM	2.71E-5		35	2.04E-4
9	SGTC_1915	st067105	3.40	30.6 µM	5.18E-5	RNA pol III & RNase P/MRP	71	3.38E-4
10	SGTC_2158	5657123	3.24	3.6 µM	1.09E-4		18	6.05E-4
11	SGTC_3001	9076041	3.20	71.4 µM	1.30E-4		32	6.94E-4
12	SGTC_704	1310-0270	2.98	142.0 µM	3.27E-4		80	0.00143
13	SGTC_2839	9003951	2.92	26.0 µM	4.24E-4		53	0.00176
14	SGTC_1059	3448-6867	2.87	171.0 µM	5.11E-4		55	0.00203
15	SGTC_2472	5377652	2.86	49.4 µM	5.37E-4	TRP & mitochondrial translation	129	0.00211
16	SGTC_417	st075190	2.85	100.0 µM	5.58E-4		63	0.00218
17	SGTC_737	1950-0117	2.82	57.9 µM	6.39E-4		75	0.00242
18	SGTC_1742	st038235	2.76	28.9 µM	7.86E-4	mitochondrial stress	197	0.00285
19	SGTC_2487	5918373	2.76	44.0 µM	8.15E-4		80	0.00293
20	SGTC_431	k089-0097	2.75	107.0 µM	8.18E-4	iron homeostasis	133	0.00294

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.211	3.26E-35	YAL054C	ACS1	hom	Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
0.199	3.41E-31	YBR258C	SHG1	hom	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.185	3.68E-27	YCL055W	KAR4	hom	Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone
0.184	5.51E-27	YNL042W-B_p	YNL042W-B_p	hom	Putative protein of unknown function
0.181	5.09E-26	YDL214C	PRR2	hom	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance
0.177	4.84E-25	YOR010C	TIR2	hom	Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.174	2.71E-24	YDR459C	PFA5	hom	Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.169	7.40E-23	YJR127C	RSF2	hom	Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.160	9.55E-21	YDR406W	PDR15	hom	Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
0.158	2.72E-20	YGL110C	CUE3	hom	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.157	5.67E-20	YGR117C_p	YGR117C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.152	6.39E-19	YLR267W_p	BOP2_p	hom	Protein of unknown function
0.148	5.81E-18	YER182W_p	FMP10_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.147	8.88E-18	YJL035C	TAD2	het	Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
0.142	1.17E-16	YDR411C	DFM1	hom	Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p