YMR184W / ADD37

Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR184W / ADD37

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.15|P-value:8.97E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.36|P-value:4.29E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.46|P-value:3.28E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.53|P-value:2.61E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-5.78|P-value:6.01E-9 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.42|P-value:3.80E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.58|P-value:2.88E-6 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.23|P-value:6.63E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:6.09|P-value:8.33E-10 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.15|P-value:8.74E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.95|P-value:4.52E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.46|P-value:2.95E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.61|P-value:1.73E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.48|P-value:2.77E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.42|P-value:3.45E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.15|P-value:8.77E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.29|P-value:5.52E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.55|P-value:2.12E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.71|P-value:1.15E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.69|P-value:1.28E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.19|P-value:7.79E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.36|P-value:4.78E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-3.29|P-value:6.02E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.47|P-value:2.84E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.25|P-value:6.92E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.14|P-value:9.15E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.21|P-value:7.95E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.44|P-value:3.16E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.70|P-value:1.20E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.13|P-value:9.49E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.15|P-value:8.97E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.36|P-value:4.29E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.46|P-value:3.28E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.53|P-value:2.61E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-5.78|P-value:6.01E-9 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.42|P-value:3.80E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.58|P-value:2.88E-6 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.23|P-value:6.63E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:6.09|P-value:8.33E-10 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.15|P-value:8.74E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.95|P-value:4.52E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.46|P-value:2.95E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.61|P-value:1.73E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.48|P-value:2.77E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.42|P-value:3.45E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.15|P-value:8.77E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.29|P-value:5.52E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.55|P-value:2.12E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.71|P-value:1.15E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.69|P-value:1.28E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.19|P-value:7.79E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.36|P-value:4.78E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-3.29|P-value:6.02E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.47|P-value:2.84E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.25|P-value:6.92E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.14|P-value:9.15E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.21|P-value:7.95E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.44|P-value:3.16E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.70|P-value:1.20E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.13|P-value:9.49E-4

Top fitness defect scores for YMR184W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1010 4112-3296 6.09 15.2 µM 8.33E-10 5 5.77E-10
2 SGTC_1008 4106-0037 4.58 6.0 µM 2.88E-6 PDR1 11 2.37E-6
3 SGTC_1176 0848-0131 3.95 83.3 µM 4.52E-5 Golgi 21 3.94E-5
4 SGTC_2298 7976326 3.71 193.8 µM 1.15E-4 15 1.02E-4
5 SGTC_3315 9136395 3.70 68.5 µM 1.20E-4 10 1.06E-4
6 SGTC_2335 9018011 3.69 154.2 µM 1.28E-4 34 1.14E-4
7 SGTC_1445 4239-0156 3.61 97.7 µM 1.73E-4 41 1.55E-4
8 SGTC_2295 7971645 3.55 200.0 µM 2.12E-4 33 1.90E-4
9 SGTC_1501 4491-0275 3.48 38.4 µM 2.77E-4 22 2.50E-4
10 SGTC_2837 9008476 3.47 45.5 µM 2.84E-4 54 2.56E-4
11 SGTC_1270 0831-1170 3.46 17.3 µM 2.95E-4 20 2.67E-4
12 SGTC_3018 9082602 3.44 49.5 µM 3.16E-4 62 2.86E-4
13 SGTC_1948 st076329 3.42 66.6 µM 3.45E-4 47 3.12E-4
14 SGTC_39 0986-0283 3.36 58.4 µM 4.29E-4 calcium & mitochondrial duress 58 3.90E-4
15 SGTC_1974 st069448 3.29 26.9 µM 5.52E-4 48 5.05E-4
16 SGTC_1009 4106-0057 3.23 9.9 µM 6.63E-4 32 6.08E-4
17 SGTC_2563 tomatine 3.19 8.5 µM 7.79E-4 91 7.17E-4
18 SGTC_1020 4335-0961 3.15 93.3 µM 8.74E-4 39 8.07E-4
19 SGTC_1972 st070201 3.15 17.4 µM 8.77E-4 52 8.09E-4
20 SGTC_38 0929-0051 3.15 58.3 µM 8.97E-4 54 8.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.73E-15 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.122 1.22E-12 YIL089W YIL089W hom Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking
0.114 3.85E-11 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.114 4.35E-11 YKL100C_p YKL100C_p hom Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.113 5.16E-11 YBL055C YBL055C hom 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
0.111 1.20E-10 YDR400W URH1 hom Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
0.101 5.13E-9 YLR273C PIG1 hom Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
0.100 7.27E-9 YKL070W_p YKL070W_p hom Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.099 9.14E-9 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.099 9.92E-9 YDR031W MIC14 hom Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.098 1.44E-8 YGR173W RBG2 hom Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
0.098 1.49E-8 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.096 2.21E-8 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.094 5.57E-8 YMR280C CAT8 hom Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress
0.093 6.78E-8 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain