YMR192W / GYL1

Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR192W / GYL1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:2.96|P-value:6.19E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-2.91|P-value:6.88E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-2.94|P-value:6.22E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:2.94|P-value:6.72E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.72|P-value:2.48E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.13|P-value:3.24E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.03|P-value:4.78E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.28|P-value:1.58E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.57|P-value:4.91E-5 ID:SGTC_834|Compound:0312-0008|FD-Score:2.84|P-value:9.73E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.22|P-value:2.00E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:-5.26|P-value:3.92E-9 ID:SGTC_855|Compound:0428-0020|FD-Score:5.03|P-value:1.89E-8 ID:SGTC_863|Compound:0466-0191|FD-Score:4.09|P-value:3.91E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-2.87|P-value:7.97E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-4.51|P-value:3.74E-7 ID:SGTC_933|Compound:2914-0560|FD-Score:2.98|P-value:5.80E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:2.91|P-value:7.45E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.19|P-value:2.46E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-2.95|P-value:5.85E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.11|P-value:3.51E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.92|P-value:9.24E-6 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.03|P-value:4.69E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.11|P-value:3.40E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-3.03|P-value:4.30E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.15|P-value:2.89E-4 ID:SGTC_1729|Compound:st035615|FD-Score:2.91|P-value:7.46E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.22|P-value:2.24E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.23|P-value:2.16E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:2.84|P-value:9.61E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.37|P-value:1.20E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.32|P-value:1.32E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.07|P-value:4.05E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-2.89|P-value:7.35E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.82|P-value:1.52E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-3.05|P-value:4.06E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-3.36|P-value:1.11E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.95|P-value:7.15E-6 ID:SGTC_2395|Compound:5646831|FD-Score:-2.95|P-value:5.92E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.38|P-value:1.11E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:4.93|P-value:3.51E-8 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.18|P-value:2.35E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.00|P-value:6.26E-6 ID:SGTC_2602|Compound:kawain|FD-Score:3.23|P-value:2.16E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.21|P-value:2.30E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.06|P-value:4.23E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.14|P-value:3.12E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-3.08|P-value:3.48E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-2.99|P-value:5.12E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:2.96|P-value:6.19E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-2.91|P-value:6.88E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-2.94|P-value:6.22E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:2.94|P-value:6.72E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.72|P-value:2.48E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.13|P-value:3.24E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.03|P-value:4.78E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.28|P-value:1.58E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.57|P-value:4.91E-5 ID:SGTC_834|Compound:0312-0008|FD-Score:2.84|P-value:9.73E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.22|P-value:2.00E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:-5.26|P-value:3.92E-9 ID:SGTC_855|Compound:0428-0020|FD-Score:5.03|P-value:1.89E-8 ID:SGTC_863|Compound:0466-0191|FD-Score:4.09|P-value:3.91E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-2.87|P-value:7.97E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-4.51|P-value:3.74E-7 ID:SGTC_933|Compound:2914-0560|FD-Score:2.98|P-value:5.80E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:2.91|P-value:7.45E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.19|P-value:2.46E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-2.95|P-value:5.85E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.11|P-value:3.51E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.92|P-value:9.24E-6 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.03|P-value:4.69E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.11|P-value:3.40E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-3.03|P-value:4.30E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.15|P-value:2.89E-4 ID:SGTC_1729|Compound:st035615|FD-Score:2.91|P-value:7.46E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.22|P-value:2.24E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.23|P-value:2.16E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:2.84|P-value:9.61E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.37|P-value:1.20E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.32|P-value:1.32E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.07|P-value:4.05E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-2.89|P-value:7.35E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.82|P-value:1.52E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-3.05|P-value:4.06E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-3.36|P-value:1.11E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.95|P-value:7.15E-6 ID:SGTC_2395|Compound:5646831|FD-Score:-2.95|P-value:5.92E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.38|P-value:1.11E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:4.93|P-value:3.51E-8 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.18|P-value:2.35E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.00|P-value:6.26E-6 ID:SGTC_2602|Compound:kawain|FD-Score:3.23|P-value:2.16E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.21|P-value:2.30E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.06|P-value:4.23E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.14|P-value:3.12E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-3.08|P-value:3.48E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-2.99|P-value:5.12E-4

Top fitness defect scores for YMR192W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_855 0428-0020 5.03 25.0 µM 1.89E-8 Golgi 10 2.40E-7
2 SGTC_2532 xanthone 4.93 78.9 µM 3.51E-8 16 4.02E-7
3 SGTC_839 0122-0028 4.22 230.0 µM 2.00E-6 RSC complex & mRNA processing 33 1.21E-5
4 SGTC_863 0466-0191 4.09 129.0 µM 3.91E-6 cell wall 67 2.12E-5
5 SGTC_2582 agaric acid 4.00 100.0 µM 6.26E-6 redox potentiating 313 3.15E-5
6 SGTC_1259 0671-0132 3.92 43.0 µM 9.24E-6 23 4.38E-5
7 SGTC_2056 5235370 3.82 200.0 µM 1.52E-5 44 6.65E-5
8 SGTC_358 0075-0058 3.72 9.4 µM 2.48E-5 73 1.01E-4
9 SGTC_751 0833-0568 3.57 350.0 µM 4.91E-5 34 1.79E-4
10 SGTC_2525 harmine 3.38 47.9 µM 1.11E-4 ergosterol biosynthesis 24 3.57E-4
11 SGTC_1885 st057546 3.37 99.9 µM 1.20E-4 34 3.83E-4
12 SGTC_2602 kawain 3.23 100.0 µM 2.16E-4 61 6.27E-4
13 SGTC_1791 st048313 3.23 56.1 µM 2.16E-4 34 6.28E-4
14 SGTC_1733 st037357 3.22 54.9 µM 2.24E-4 60S ribosome export 78 6.46E-4
15 SGTC_2794 7785382 3.21 27.3 µM 2.30E-4 72 6.61E-4
16 SGTC_1215 3852-0577 3.19 11.2 µM 2.46E-4 39 7.02E-4
17 SGTC_1620 st003704 3.15 16.5 µM 2.89E-4 41 8.04E-4
18 SGTC_2938 9059746 3.14 27.3 µM 3.12E-4 fatty acid desaturase (OLE1) 72 8.56E-4
19 SGTC_632 0781-2353 3.13 4.7 µM 3.24E-4 Golgi 83 8.85E-4
20 SGTC_1273 0849-0096 3.11 14.1 µM 3.40E-4 RPP1 & pyrimidine depletion 48 9.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 5.21E-19 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.132 1.50E-14 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.122 1.28E-12 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.117 9.91E-12 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.117 1.12E-11 YHR001W-A QCR10 hom Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
0.115 2.65E-11 YOL163W_p YOL163W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.114 4.24E-11 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.111 1.04E-10 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.111 1.29E-10 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.110 1.43E-10 YGR087C PDC6 hom Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
0.106 7.38E-10 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.105 8.91E-10 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.104 1.54E-9 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.103 2.27E-9 YOR377W ATF1 hom Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism
0.099 8.91E-9 YFL003C MSH4 hom Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein