YMR194W / RPL36A

Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR194W / RPL36A

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-4.90|P-value:2.44E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:3.90|P-value:2.55E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:3.14|P-value:5.28E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.12|P-value:7.05E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.56|P-value:1.08E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.17|P-value:4.73E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.02|P-value:8.31E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.86|P-value:3.05E-5 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.32|P-value:3.30E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.24|P-value:3.70E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.82|P-value:3.53E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:-4.29|P-value:5.29E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.39|P-value:2.58E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.25|P-value:3.60E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.47|P-value:1.54E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.24|P-value:3.67E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.47|P-value:1.38E-11 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.94|P-value:2.63E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.76|P-value:5.83E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.89|P-value:2.56E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.03|P-value:8.06E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.39|P-value:2.13E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.00|P-value:8.95E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.23|P-value:3.92E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.04|P-value:1.36E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.34|P-value:2.54E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.06|P-value:7.29E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.98|P-value:1.14E-7 ID:SGTC_1920|Compound:st075728|FD-Score:3.65|P-value:7.24E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-3.77|P-value:5.59E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.41|P-value:1.93E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.55|P-value:1.11E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.22|P-value:4.85E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.66|P-value:6.89E-5 ID:SGTC_2032|Compound:5185112|FD-Score:4.34|P-value:3.32E-6 ID:SGTC_2064|Compound:5220758|FD-Score:3.35|P-value:2.44E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.03|P-value:1.39E-5 ID:SGTC_2256|Compound:7954252|FD-Score:3.46|P-value:1.62E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.97|P-value:1.66E-7 ID:SGTC_2308|Compound:7584454|FD-Score:3.11|P-value:5.99E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.40|P-value:1.97E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.16|P-value:4.97E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.13|P-value:6.70E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:5.08|P-value:6.84E-8 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-4.54|P-value:1.53E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.05|P-value:8.97E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:6.57|P-value:4.76E-12 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.72|P-value:5.34E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.13|P-value:6.69E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.27|P-value:4.04E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.20|P-value:4.30E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.27|P-value:4.54E-6 ID:SGTC_2643|Compound:anethole|FD-Score:3.05|P-value:7.45E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.05|P-value:7.98E-8 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.30|P-value:2.97E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.06|P-value:7.18E-4 ID:SGTC_2894|Compound:9048625|FD-Score:4.84|P-value:2.44E-7 ID:SGTC_2913|Compound:7966556|FD-Score:3.74|P-value:5.00E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.15|P-value:5.22E-4 ID:SGTC_2946|Compound:9065502|FD-Score:3.21|P-value:4.17E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-5.48|P-value:8.62E-9 ID:SGTC_2950|Compound:9072895|FD-Score:-8.54|P-value:7.39E-19 ID:SGTC_3020|Compound:9089140|FD-Score:3.05|P-value:7.47E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.57|P-value:1.04E-4 ID:SGTC_3107|Compound:9121808|FD-Score:4.08|P-value:1.11E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-6.92|P-value:5.17E-13 ID:SGTC_3213|Compound:9129884|FD-Score:4.22|P-value:5.70E-6 ID:SGTC_3214|Compound:9129694|FD-Score:7.48|P-value:4.33E-15 ID:SGTC_3217|Compound:9129673|FD-Score:6.05|P-value:1.78E-10 ID:SGTC_3218|Compound:9131285|FD-Score:3.87|P-value:2.86E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.11|P-value:6.08E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-4.77|P-value:4.72E-7 ID:SGTC_3327|Compound:9140648|FD-Score:3.04|P-value:7.60E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.90|P-value:2.44E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:3.90|P-value:2.55E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:3.14|P-value:5.28E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.12|P-value:7.05E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.56|P-value:1.08E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.17|P-value:4.73E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.02|P-value:8.31E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.86|P-value:3.05E-5 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.32|P-value:3.30E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.24|P-value:3.70E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.82|P-value:3.53E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:-4.29|P-value:5.29E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.39|P-value:2.58E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.25|P-value:3.60E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.47|P-value:1.54E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.24|P-value:3.67E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.47|P-value:1.38E-11 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.94|P-value:2.63E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.76|P-value:5.83E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.89|P-value:2.56E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.03|P-value:8.06E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.39|P-value:2.13E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.00|P-value:8.95E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.23|P-value:3.92E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.04|P-value:1.36E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.34|P-value:2.54E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.06|P-value:7.29E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.98|P-value:1.14E-7 ID:SGTC_1920|Compound:st075728|FD-Score:3.65|P-value:7.24E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-3.77|P-value:5.59E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.41|P-value:1.93E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.55|P-value:1.11E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.22|P-value:4.85E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.66|P-value:6.89E-5 ID:SGTC_2032|Compound:5185112|FD-Score:4.34|P-value:3.32E-6 ID:SGTC_2064|Compound:5220758|FD-Score:3.35|P-value:2.44E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.03|P-value:1.39E-5 ID:SGTC_2256|Compound:7954252|FD-Score:3.46|P-value:1.62E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.97|P-value:1.66E-7 ID:SGTC_2308|Compound:7584454|FD-Score:3.11|P-value:5.99E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.40|P-value:1.97E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.16|P-value:4.97E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.13|P-value:6.70E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:5.08|P-value:6.84E-8 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-4.54|P-value:1.53E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.05|P-value:8.97E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:6.57|P-value:4.76E-12 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.72|P-value:5.34E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.13|P-value:6.69E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.27|P-value:4.04E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.20|P-value:4.30E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.27|P-value:4.54E-6 ID:SGTC_2643|Compound:anethole|FD-Score:3.05|P-value:7.45E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.05|P-value:7.98E-8 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.30|P-value:2.97E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.06|P-value:7.18E-4 ID:SGTC_2894|Compound:9048625|FD-Score:4.84|P-value:2.44E-7 ID:SGTC_2913|Compound:7966556|FD-Score:3.74|P-value:5.00E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.15|P-value:5.22E-4 ID:SGTC_2946|Compound:9065502|FD-Score:3.21|P-value:4.17E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-5.48|P-value:8.62E-9 ID:SGTC_2950|Compound:9072895|FD-Score:-8.54|P-value:7.39E-19 ID:SGTC_3020|Compound:9089140|FD-Score:3.05|P-value:7.47E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.57|P-value:1.04E-4 ID:SGTC_3107|Compound:9121808|FD-Score:4.08|P-value:1.11E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-6.92|P-value:5.17E-13 ID:SGTC_3213|Compound:9129884|FD-Score:4.22|P-value:5.70E-6 ID:SGTC_3214|Compound:9129694|FD-Score:7.48|P-value:4.33E-15 ID:SGTC_3217|Compound:9129673|FD-Score:6.05|P-value:1.78E-10 ID:SGTC_3218|Compound:9131285|FD-Score:3.87|P-value:2.86E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.11|P-value:6.08E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-4.77|P-value:4.72E-7 ID:SGTC_3327|Compound:9140648|FD-Score:3.04|P-value:7.60E-4

Top fitness defect scores for YMR194W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3214 9129694 7.48 49.5 µM 4.33E-15 1 3.61E-14
2 SGTC_2555 cholic acid 6.57 100.0 µM 4.76E-12 3 2.51E-11
3 SGTC_3217 9129673 6.05 49.5 µM 1.78E-10 6 7.43E-10
4 SGTC_2544 sphondin 5.08 68.5 µM 6.84E-8 RNA pol III & RNase P/MRP 11 1.93E-7
5 SGTC_2688 kanamycin b 5.05 96.7 µM 7.98E-8 calcium & mitochondrial duress 239 2.23E-7
6 SGTC_1856 st057054 4.98 55.7 µM 1.14E-7 12 3.13E-7
7 SGTC_2894 9048625 4.84 32.5 µM 2.44E-7 4 6.35E-7
8 SGTC_2032 5185112 4.34 26.0 µM 3.32E-6 8 7.29E-6
9 SGTC_2640 pentamidine 4.27 10.4 µM 4.54E-6 mitochondrial processes 23 9.75E-6
10 SGTC_3213 9129884 4.22 49.5 µM 5.70E-6 18 1.21E-5
11 SGTC_3107 9121808 4.08 49.5 µM 1.11E-5 6 2.24E-5
12 SGTC_1596 piperlongumine 4.04 63.0 µM 1.36E-5 16 2.72E-5
13 SGTC_2083 5306046 4.03 65.9 µM 1.39E-5 26 2.77E-5
14 SGTC_64 000l-0018 3.90 272.1 µM 2.55E-5 ubiquinone biosynthesis & proteasome 152 4.88E-5
15 SGTC_1132 3456-3614 3.89 2.5 µM 2.56E-5 tubulin folding & SWR complex 47 4.91E-5
16 SGTC_3218 9131285 3.87 49.5 µM 2.86E-5 endomembrane recycling 45 5.45E-5
17 SGTC_391 gliotoxin 3.86 8.3 µM 3.05E-5 68 5.78E-5
18 SGTC_598 3937-0236 3.82 20.2 µM 3.53E-5 ERG2 28 6.63E-5
19 SGTC_2913 7966556 3.74 36.6 µM 5.00E-5 60S ribosome export 17 9.18E-5
20 SGTC_2558 carylophyllene oxide 3.72 100.0 µM 5.34E-5 18 9.77E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 2.15E-20 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.157 5.57E-20 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.151 1.19E-18 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.147 1.15E-17 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.146 2.32E-17 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.130 3.86E-14 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.128 8.58E-14 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.122 1.59E-12 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
0.119 4.01E-12 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.119 4.83E-12 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.118 7.61E-12 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.114 2.97E-11 YKL034W TUL1 hom Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1
0.113 4.49E-11 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.112 9.44E-11 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.108 3.20E-10 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases