YMR199W / CLN1

G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR199W / CLN1

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:3.04|P-value:5.19E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.02|P-value:5.71E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.23|P-value:2.54E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.20|P-value:2.77E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.05|P-value:5.03E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:2.88|P-value:9.44E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:2.89|P-value:9.29E-4 ID:SGTC_417|Compound:st075190|FD-Score:-3.69|P-value:4.16E-5 ID:SGTC_433|Compound:pimozide|FD-Score:3.05|P-value:5.09E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:2.90|P-value:8.93E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.66|P-value:3.98E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:4.46|P-value:8.05E-7 ID:SGTC_994|Compound:3910-0338|FD-Score:3.60|P-value:5.17E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.32|P-value:1.70E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.51|P-value:6.00E-7 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.43|P-value:1.09E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.01|P-value:5.83E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.29|P-value:1.94E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.23|P-value:2.70E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.20|P-value:3.09E-6 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.39|P-value:1.29E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.20|P-value:2.83E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:2.98|P-value:6.59E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:4.73|P-value:1.75E-7 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.32|P-value:1.71E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:5.05|P-value:2.71E-8 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:2.88|P-value:9.64E-4 ID:SGTC_1606|Compound:st000094|FD-Score:4.39|P-value:1.16E-6 ID:SGTC_1746|Compound:st038117|FD-Score:3.02|P-value:5.67E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.07|P-value:5.37E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.22|P-value:2.64E-4 ID:SGTC_1791|Compound:st048313|FD-Score:4.26|P-value:2.22E-6 ID:SGTC_1798|Compound:st045719|FD-Score:-3.44|P-value:1.20E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.92|P-value:1.24E-5 ID:SGTC_1948|Compound:st076329|FD-Score:4.08|P-value:5.46E-6 ID:SGTC_1958|Compound:st076513|FD-Score:3.62|P-value:4.74E-5 ID:SGTC_1987|Compound:st072290|FD-Score:2.94|P-value:7.59E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.79|P-value:2.24E-5 ID:SGTC_2004|Compound:4023728|FD-Score:4.15|P-value:3.97E-6 ID:SGTC_2024|Compound:5144227|FD-Score:3.13|P-value:3.71E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.16|P-value:3.30E-4 ID:SGTC_2038|Compound:4100038|FD-Score:4.41|P-value:1.06E-6 ID:SGTC_2063|Compound:5246145|FD-Score:3.63|P-value:4.52E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-4.04|P-value:7.81E-6 ID:SGTC_2132|Compound:5317594|FD-Score:-3.34|P-value:1.82E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-2.95|P-value:8.27E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.16|P-value:3.25E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.11|P-value:4.03E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.82|P-value:1.06E-7 ID:SGTC_2625|Compound:euphol|FD-Score:5.89|P-value:1.21E-10 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.54|P-value:6.98E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.12|P-value:4.62E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.62|P-value:4.91E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:4.10|P-value:5.11E-6 ID:SGTC_2914|Compound:7968218|FD-Score:4.32|P-value:1.66E-6 ID:SGTC_2999|Compound:9069765|FD-Score:3.81|P-value:2.08E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.48|P-value:8.95E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-3.57|P-value:7.02E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:3.04|P-value:5.19E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.02|P-value:5.71E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.23|P-value:2.54E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.20|P-value:2.77E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.05|P-value:5.03E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:2.88|P-value:9.44E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:2.89|P-value:9.29E-4 ID:SGTC_417|Compound:st075190|FD-Score:-3.69|P-value:4.16E-5 ID:SGTC_433|Compound:pimozide|FD-Score:3.05|P-value:5.09E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:2.90|P-value:8.93E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.66|P-value:3.98E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:4.46|P-value:8.05E-7 ID:SGTC_994|Compound:3910-0338|FD-Score:3.60|P-value:5.17E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.32|P-value:1.70E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.51|P-value:6.00E-7 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.43|P-value:1.09E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.01|P-value:5.83E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.29|P-value:1.94E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.23|P-value:2.70E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.20|P-value:3.09E-6 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.39|P-value:1.29E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.20|P-value:2.83E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:2.98|P-value:6.59E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:4.73|P-value:1.75E-7 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.32|P-value:1.71E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:5.05|P-value:2.71E-8 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:2.88|P-value:9.64E-4 ID:SGTC_1606|Compound:st000094|FD-Score:4.39|P-value:1.16E-6 ID:SGTC_1746|Compound:st038117|FD-Score:3.02|P-value:5.67E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.07|P-value:5.37E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.22|P-value:2.64E-4 ID:SGTC_1791|Compound:st048313|FD-Score:4.26|P-value:2.22E-6 ID:SGTC_1798|Compound:st045719|FD-Score:-3.44|P-value:1.20E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.92|P-value:1.24E-5 ID:SGTC_1948|Compound:st076329|FD-Score:4.08|P-value:5.46E-6 ID:SGTC_1958|Compound:st076513|FD-Score:3.62|P-value:4.74E-5 ID:SGTC_1987|Compound:st072290|FD-Score:2.94|P-value:7.59E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.79|P-value:2.24E-5 ID:SGTC_2004|Compound:4023728|FD-Score:4.15|P-value:3.97E-6 ID:SGTC_2024|Compound:5144227|FD-Score:3.13|P-value:3.71E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.16|P-value:3.30E-4 ID:SGTC_2038|Compound:4100038|FD-Score:4.41|P-value:1.06E-6 ID:SGTC_2063|Compound:5246145|FD-Score:3.63|P-value:4.52E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-4.04|P-value:7.81E-6 ID:SGTC_2132|Compound:5317594|FD-Score:-3.34|P-value:1.82E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-2.95|P-value:8.27E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.16|P-value:3.25E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.11|P-value:4.03E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.82|P-value:1.06E-7 ID:SGTC_2625|Compound:euphol|FD-Score:5.89|P-value:1.21E-10 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.54|P-value:6.98E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.12|P-value:4.62E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.62|P-value:4.91E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:4.10|P-value:5.11E-6 ID:SGTC_2914|Compound:7968218|FD-Score:4.32|P-value:1.66E-6 ID:SGTC_2999|Compound:9069765|FD-Score:3.81|P-value:2.08E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.48|P-value:8.95E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-3.57|P-value:7.02E-5

Top fitness defect scores for YMR199W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2625 euphol 5.89 100.0 µM 1.21E-10 6 1.96E-9
2 SGTC_1544 7-methoxy-4-methylcoumarin 5.05 105.0 µM 2.71E-8 6 2.18E-7
3 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 4.82 54.6 µM 1.06E-7 RPP1 & pyrimidine depletion 16 7.15E-7
4 SGTC_1499 4480-0877 4.73 67.3 µM 1.75E-7 2 1.10E-6
5 SGTC_1012 4112-3522 4.51 18.0 µM 6.00E-7 17 3.23E-6
6 SGTC_945 3381-0768 4.46 11.3 µM 8.05E-7 endomembrane recycling 24 4.17E-6
7 SGTC_2038 4100038 4.41 31.0 µM 1.06E-6 plasma membrane duress 35 5.28E-6
8 SGTC_1606 st000094 4.39 49.2 µM 1.16E-6 60S ribosome export 8 5.72E-6
9 SGTC_2914 7968218 4.32 45.3 µM 1.66E-6 9 7.81E-6
10 SGTC_1791 st048313 4.26 56.1 µM 2.22E-6 9 1.01E-5
11 SGTC_1132 3456-3614 4.23 2.5 µM 2.70E-6 tubulin folding & SWR complex 31 1.19E-5
12 SGTC_1134 3477-0009 4.20 42.5 µM 3.09E-6 40 1.35E-5
13 SGTC_2004 4023728 4.15 41.9 µM 3.97E-6 22 1.67E-5
14 SGTC_2750 bromebric acid 4.12 70.2 µM 4.62E-6 24 1.91E-5
15 SGTC_2769 toremifene 4.10 3.7 µM 5.11E-6 19 2.08E-5
16 SGTC_1948 st076329 4.08 66.6 µM 5.46E-6 25 2.21E-5
17 SGTC_1830 st055982 3.92 50.3 µM 1.24E-5 18 4.50E-5
18 SGTC_2999 9069765 3.81 71.4 µM 2.08E-5 amide catabolism 32 7.08E-5
19 SGTC_1988 st071872 3.79 53.4 µM 2.24E-5 11 7.56E-5
20 SGTC_939 1165-0479 3.66 45.3 µM 3.98E-5 41 1.25E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 7.20E-13 YOR380W RDR1 hom Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins
0.121 1.69E-12 YBR153W RIB7 het Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
0.106 6.60E-10 YLR363W-A YLR363W-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
0.100 6.08E-9 YHR118C ORC6 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
0.100 6.09E-9 YLR112W_d YLR112W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.092 8.87E-8 YNL318C HXT14 hom Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.090 1.96E-7 YER153C PET122 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane
0.088 2.88E-7 YER109C FLO8 hom Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
0.086 6.05E-7 YLR307C-A_p YLR307C-A_p hom Putative protein of unknown function
0.086 6.20E-7 YKR061W KTR2 hom Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication
0.085 7.53E-7 YBR053C_p YBR053C_p hom Putative protein of unknown function; induced by cell wall perturbation
0.085 7.58E-7 YNL206C RTT106 hom Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition
0.085 8.27E-7 YIR014W_p YIR014W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene
0.085 9.52E-7 YMR175W-A_p YMR175W-A_p hom Putative protein of unknown function
0.084 1.10E-6 YBL049W MOH1 hom Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase