YMR204C / INP1

Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR204C / INP1

Click on Significant Values for Screen Details ID:SGTC_169|Compound:k015-0017|FD-Score:-3.63|P-value:1.03E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.08|P-value:6.97E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.17|P-value:5.06E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:4.22|P-value:6.27E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:-6.14|P-value:1.61E-10 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.09|P-value:7.98E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.61|P-value:9.23E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.11|P-value:6.39E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.06|P-value:7.45E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.64|P-value:1.02E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.83|P-value:3.64E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.00|P-value:9.22E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.02|P-value:8.78E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.74|P-value:4.85E-7 ID:SGTC_1856|Compound:st057054|FD-Score:-3.12|P-value:7.35E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.18|P-value:5.86E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.46|P-value:1.71E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.44|P-value:1.84E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.00|P-value:1.72E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-5.03|P-value:1.29E-7 ID:SGTC_1943|Compound:st076331|FD-Score:-3.34|P-value:3.30E-4 ID:SGTC_1987|Compound:st072290|FD-Score:-3.48|P-value:1.87E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.48|P-value:1.77E-6 ID:SGTC_2037|Compound:5169046|FD-Score:3.69|P-value:6.71E-5 ID:SGTC_2081|Compound:5214970|FD-Score:3.41|P-value:2.05E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.12|P-value:9.97E-6 ID:SGTC_2245|Compound:6637752|FD-Score:-3.30|P-value:3.85E-4 ID:SGTC_2361|Compound:9034121|FD-Score:-3.66|P-value:9.18E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.45|P-value:1.77E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.01|P-value:8.95E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.20|P-value:5.57E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:4.12|P-value:9.90E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.63|P-value:1.05E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-5.27|P-value:3.39E-8 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.11|P-value:6.37E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.50|P-value:1.73E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.21|P-value:4.37E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.94|P-value:2.89E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-3.99|P-value:2.30E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-3.32|P-value:3.56E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.15|P-value:5.55E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.24|P-value:4.77E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.79|P-value:4.40E-5 ID:SGTC_3173|Compound:9105693|FD-Score:2.99|P-value:9.49E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.60|P-value:9.79E-5 ID:SGTC_3310|Compound:9130229|FD-Score:-3.49|P-value:1.80E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.63|P-value:1.03E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.08|P-value:6.97E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.17|P-value:5.06E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:4.22|P-value:6.27E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:-6.14|P-value:1.61E-10 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.09|P-value:7.98E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.61|P-value:9.23E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.11|P-value:6.39E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.06|P-value:7.45E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.64|P-value:1.02E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.83|P-value:3.64E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.00|P-value:9.22E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.02|P-value:8.78E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.74|P-value:4.85E-7 ID:SGTC_1856|Compound:st057054|FD-Score:-3.12|P-value:7.35E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.18|P-value:5.86E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.46|P-value:1.71E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.44|P-value:1.84E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.00|P-value:1.72E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-5.03|P-value:1.29E-7 ID:SGTC_1943|Compound:st076331|FD-Score:-3.34|P-value:3.30E-4 ID:SGTC_1987|Compound:st072290|FD-Score:-3.48|P-value:1.87E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.48|P-value:1.77E-6 ID:SGTC_2037|Compound:5169046|FD-Score:3.69|P-value:6.71E-5 ID:SGTC_2081|Compound:5214970|FD-Score:3.41|P-value:2.05E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.12|P-value:9.97E-6 ID:SGTC_2245|Compound:6637752|FD-Score:-3.30|P-value:3.85E-4 ID:SGTC_2361|Compound:9034121|FD-Score:-3.66|P-value:9.18E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.45|P-value:1.77E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.01|P-value:8.95E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.20|P-value:5.57E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:4.12|P-value:9.90E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.63|P-value:1.05E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-5.27|P-value:3.39E-8 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.11|P-value:6.37E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.50|P-value:1.73E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.21|P-value:4.37E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.94|P-value:2.89E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-3.99|P-value:2.30E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-3.32|P-value:3.56E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.15|P-value:5.55E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.24|P-value:4.77E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.79|P-value:4.40E-5 ID:SGTC_3173|Compound:9105693|FD-Score:2.99|P-value:9.49E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.60|P-value:9.79E-5 ID:SGTC_3310|Compound:9130229|FD-Score:-3.49|P-value:1.80E-4

Top fitness defect scores for YMR204C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1855 st056195 4.74 39.6 µM 4.85E-7 60S ribosome export 6 1.09E-6
2 SGTC_1993 st073995 4.48 70.8 µM 1.77E-6 12 3.69E-6
3 SGTC_876 0720-0963 4.22 56.8 µM 6.27E-6 8 1.21E-5
4 SGTC_2532 xanthone 4.12 78.9 µM 9.90E-6 22 1.87E-5
5 SGTC_2166 5933061 4.12 31.5 µM 9.97E-6 tubulin folding & SWR complex 37 1.88E-5
6 SGTC_1883 5-benzylidenerhodanine 4.00 20.0 µM 1.72E-5 TRP & mitochondrial translation 69 3.15E-5
7 SGTC_1584 6-fluoro-dl-tryptophan 3.83 90.0 µM 3.64E-5 mitochondrial processes 16 6.37E-5
8 SGTC_3147 9097027 3.79 49.5 µM 4.40E-5 30 7.61E-5
9 SGTC_2037 5169046 3.69 200.0 µM 6.71E-5 60S ribosome export 18 1.13E-4
10 SGTC_1196 1588-0294 3.61 184.0 µM 9.23E-5 21 1.53E-4
11 SGTC_3181 9108277 3.60 49.5 µM 9.79E-5 iron homeostasis 27 1.62E-4
12 SGTC_1870 st057514 3.46 26.5 µM 1.71E-4 RSC & ERG11 40 2.74E-4
13 SGTC_2367 9070478 3.45 135.4 µM 1.77E-4 cell wall 59 2.83E-4
14 SGTC_1878 temozolomide 3.44 1.0 mM 1.84E-4 18 2.93E-4
15 SGTC_2081 5214970 3.41 32.3 µM 2.05E-4 41 3.24E-4
16 SGTC_2794 7785382 3.21 27.3 µM 4.37E-4 73 6.63E-4
17 SGTC_763 3453-1109 3.17 128.0 µM 5.06E-4 44 7.60E-4
18 SGTC_3041 9091929 3.15 49.5 µM 5.55E-4 redox potentiating 50 8.30E-4
19 SGTC_2662 daunorubicin 3.11 22.4 µM 6.37E-4 anthracycline transcription coupled DNA repair 44 9.45E-4
20 SGTC_1274 0865-0114 3.11 173.0 µM 6.39E-4 49 9.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.66E-12 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.108 2.98E-10 YNL118C DCP2 het Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress
0.089 2.28E-7 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.086 5.93E-7 YDR266C HEL2 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor
0.082 1.82E-6 YAL054C ACS1 hom Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
0.077 8.45E-6 YNL057W_d YNL057W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.077 9.08E-6 YDR259C YAP6 hom Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication
0.076 1.11E-5 YPL119C DBP1 hom Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress
0.074 1.99E-5 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.071 3.75E-5 YLR290C_p YLR290C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene
0.070 5.47E-5 YFR006W_p YFR006W_p hom Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene
0.069 6.30E-5 YNL265C IST1 hom Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p
0.068 7.67E-5 YEL058W PCM1 het Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.067 1.10E-4 YNL050C_p YNL050C_p hom Putative protein of unknown function; YNL050c is not an essential gene
0.066 1.18E-4 YIR001C SGN1 hom Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation