YMR221C_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR221C / YMR221C

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:6.24|P-value:2.42E-11 ID:SGTC_70|Compound:0141-0289|FD-Score:-7.52|P-value:8.56E-16 ID:SGTC_73|Compound:0327-0325|FD-Score:8.72|P-value:1.89E-20 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.38|P-value:1.69E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.03|P-value:7.30E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.04|P-value:6.96E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.14|P-value:4.30E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.31|P-value:2.52E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.11|P-value:4.72E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.05|P-value:6.67E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.56|P-value:8.95E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:2.99|P-value:8.50E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.40|P-value:1.72E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.23|P-value:3.38E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.17|P-value:4.31E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.01|P-value:7.76E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.26|P-value:3.07E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.12|P-value:5.19E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-3.05|P-value:5.95E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.54|P-value:9.64E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.79|P-value:3.26E-5 ID:SGTC_1817|Compound:st052116|FD-Score:3.78|P-value:3.43E-5 ID:SGTC_1819|Compound:st053448|FD-Score:-2.96|P-value:8.39E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.89|P-value:1.28E-7 ID:SGTC_2013|Compound:4024628|FD-Score:3.16|P-value:4.42E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.12|P-value:5.19E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.19|P-value:3.90E-4 ID:SGTC_2205|Compound:7238770|FD-Score:-3.01|P-value:6.84E-4 ID:SGTC_2217|Compound:6934799|FD-Score:3.28|P-value:2.77E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-2.96|P-value:8.24E-4 ID:SGTC_2336|Compound:9001819|FD-Score:5.51|P-value:3.26E-9 ID:SGTC_2437|Compound:5741531|FD-Score:4.14|P-value:6.60E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.65|P-value:6.03E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:7.67|P-value:3.07E-16 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.67|P-value:4.88E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:4.43|P-value:1.51E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.91|P-value:1.66E-13 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.58|P-value:5.90E-7 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.56|P-value:8.91E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:4.08|P-value:8.62E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.55|P-value:8.20E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.67|P-value:5.59E-5 ID:SGTC_2744|Compound:captopril|FD-Score:3.27|P-value:2.92E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.66|P-value:5.10E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-5.07|P-value:3.80E-8 ID:SGTC_2841|Compound:9004761|FD-Score:3.43|P-value:1.53E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.01|P-value:7.87E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.13|P-value:4.35E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.51|P-value:1.12E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.44|P-value:1.51E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:6.24|P-value:2.42E-11 ID:SGTC_70|Compound:0141-0289|FD-Score:-7.52|P-value:8.56E-16 ID:SGTC_73|Compound:0327-0325|FD-Score:8.72|P-value:1.89E-20 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.38|P-value:1.69E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.03|P-value:7.30E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.04|P-value:6.96E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.14|P-value:4.30E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.31|P-value:2.52E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.11|P-value:4.72E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.05|P-value:6.67E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.56|P-value:8.95E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:2.99|P-value:8.50E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.40|P-value:1.72E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.23|P-value:3.38E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.17|P-value:4.31E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.01|P-value:7.76E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.26|P-value:3.07E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.12|P-value:5.19E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-3.05|P-value:5.95E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.54|P-value:9.64E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.79|P-value:3.26E-5 ID:SGTC_1817|Compound:st052116|FD-Score:3.78|P-value:3.43E-5 ID:SGTC_1819|Compound:st053448|FD-Score:-2.96|P-value:8.39E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.89|P-value:1.28E-7 ID:SGTC_2013|Compound:4024628|FD-Score:3.16|P-value:4.42E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.12|P-value:5.19E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.19|P-value:3.90E-4 ID:SGTC_2205|Compound:7238770|FD-Score:-3.01|P-value:6.84E-4 ID:SGTC_2217|Compound:6934799|FD-Score:3.28|P-value:2.77E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-2.96|P-value:8.24E-4 ID:SGTC_2336|Compound:9001819|FD-Score:5.51|P-value:3.26E-9 ID:SGTC_2437|Compound:5741531|FD-Score:4.14|P-value:6.60E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.65|P-value:6.03E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:7.67|P-value:3.07E-16 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.67|P-value:4.88E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:4.43|P-value:1.51E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.91|P-value:1.66E-13 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.58|P-value:5.90E-7 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.56|P-value:8.91E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:4.08|P-value:8.62E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.55|P-value:8.20E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.67|P-value:5.59E-5 ID:SGTC_2744|Compound:captopril|FD-Score:3.27|P-value:2.92E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.66|P-value:5.10E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-5.07|P-value:3.80E-8 ID:SGTC_2841|Compound:9004761|FD-Score:3.43|P-value:1.53E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.01|P-value:7.87E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.13|P-value:4.35E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.51|P-value:1.12E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.44|P-value:1.51E-4

Top fitness defect scores for YMR221C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_73 0327-0325 8.72 16.2 µM 1.89E-20 DNA damage response 5 1.44E-18
2 SGTC_2500 5-alpha-androstan-3,17-dione 7.67 61.4 µM 3.07E-16 3 8.76E-15
3 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 6.91 92.6 µM 1.66E-13 2 2.51E-12
4 SGTC_68 0986-0284 6.24 82.8 µM 2.42E-11 17 2.21E-10
5 SGTC_2336 9001819 5.51 198.7 µM 3.26E-9 heme biosynthesis & mitochondrial translocase 13 1.83E-8
6 SGTC_1935 st074532 4.89 41.6 µM 1.28E-7 12 5.00E-7
7 SGTC_2574 2',4'-dihydroxychalcone 4.55 14.6 µM 8.20E-7 13 2.66E-6
8 SGTC_2507 purpurin 4.43 79.7 µM 1.51E-6 copper-dependent oxidative stress 26 4.62E-6
9 SGTC_2437 5741531 4.14 144.2 µM 6.60E-6 33 1.75E-5
10 SGTC_2563 tomatine 4.08 8.5 µM 8.62E-6 44 2.22E-5
11 SGTC_1779 st039427 3.79 55.0 µM 3.26E-5 32 7.40E-5
12 SGTC_1817 st052116 3.78 64.4 µM 3.43E-5 RNA processing & uracil transport 17 7.75E-5
13 SGTC_2575 plumbagin 3.67 510.0 nM 5.59E-5 superoxide 53 1.20E-4
14 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.65 3.7 µM 6.03E-5 106 1.29E-4
15 SGTC_2552 juarezic acid 3.56 87.0 µM 8.91E-5 TSC3-RPN4 54 1.84E-4
16 SGTC_938 3126-1755 3.56 342.0 µM 8.95E-5 19 1.84E-4
17 SGTC_1777 st045864 3.54 34.8 µM 9.64E-5 15 1.97E-4
18 SGTC_3294 9122953 3.51 26.3 µM 1.12E-4 tubulin folding & SWR complex 48 2.27E-4
19 SGTC_3349 9149703 3.44 23.0 µM 1.51E-4 26 2.95E-4
20 SGTC_2841 9004761 3.43 39.0 µM 1.53E-4 amide catabolism 53 2.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.07E-15 YBR227C MCX1 hom Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins
0.133 1.05E-14 YKL197C PEX1 hom AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis
0.125 3.45E-13 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.125 3.82E-13 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
0.123 7.32E-13 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.117 8.69E-12 YJR056C YJR056C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress
0.112 7.12E-11 YGL153W PEX14 hom Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p
0.110 1.96E-10 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.109 2.82E-10 YMR105C PGM2 hom Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress
0.109 2.88E-10 YMR144W_p YMR144W_p hom Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
0.106 7.18E-10 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.101 4.62E-9 YLR346C_p YLR346C_p hom Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
0.099 7.69E-9 YCR016W_p YCR016W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis
0.096 2.86E-8 YBR035C PDX3 hom Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
0.095 3.99E-8 YOR118W RTC5 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity