YMR294W-A_d

Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR294W-A / YMR294W-A

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:-3.06|P-value:9.57E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.08|P-value:1.92E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:4.04|P-value:3.71E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.22|P-value:8.47E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.64|P-value:1.17E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.17|P-value:9.88E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:4.88|P-value:8.11E-7 ID:SGTC_848|Compound:0368-0089|FD-Score:3.42|P-value:4.18E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-3.87|P-value:4.80E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.02|P-value:4.12E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.18|P-value:2.05E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.62|P-value:1.28E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.67|P-value:2.28E-6 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.19|P-value:6.10E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.01|P-value:4.33E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.85|P-value:8.04E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.08|P-value:8.99E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.59|P-value:2.22E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:-3.60|P-value:1.39E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.82|P-value:9.20E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:4.59|P-value:3.30E-6 ID:SGTC_1611|Compound:st001856|FD-Score:3.31|P-value:6.20E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.59|P-value:2.26E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.26|P-value:7.35E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.42|P-value:2.68E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.75|P-value:1.22E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.46|P-value:3.55E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.29|P-value:6.47E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.81|P-value:9.72E-5 ID:SGTC_2517|Compound:totarol|FD-Score:4.56|P-value:3.73E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-9.26|P-value:1.02E-20 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.35|P-value:5.33E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-4.20|P-value:1.14E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.11|P-value:1.22E-12 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.69|P-value:1.55E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.35|P-value:5.27E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.17|P-value:9.78E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.56|P-value:3.78E-6 ID:SGTC_2783|Compound:7738165|FD-Score:4.74|P-value:1.65E-6 ID:SGTC_3211|Compound:9128781|FD-Score:3.97|P-value:5.08E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.06|P-value:9.57E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.08|P-value:1.92E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:4.04|P-value:3.71E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.22|P-value:8.47E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.64|P-value:1.17E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.17|P-value:9.88E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:4.88|P-value:8.11E-7 ID:SGTC_848|Compound:0368-0089|FD-Score:3.42|P-value:4.18E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-3.87|P-value:4.80E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.02|P-value:4.12E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.18|P-value:2.05E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.62|P-value:1.28E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.67|P-value:2.28E-6 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.19|P-value:6.10E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.01|P-value:4.33E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.85|P-value:8.04E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.08|P-value:8.99E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.59|P-value:2.22E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:-3.60|P-value:1.39E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.82|P-value:9.20E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:4.59|P-value:3.30E-6 ID:SGTC_1611|Compound:st001856|FD-Score:3.31|P-value:6.20E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.59|P-value:2.26E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.26|P-value:7.35E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.42|P-value:2.68E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.75|P-value:1.22E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.46|P-value:3.55E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.29|P-value:6.47E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.81|P-value:9.72E-5 ID:SGTC_2517|Compound:totarol|FD-Score:4.56|P-value:3.73E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-9.26|P-value:1.02E-20 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.35|P-value:5.33E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-4.20|P-value:1.14E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.11|P-value:1.22E-12 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.69|P-value:1.55E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.35|P-value:5.27E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.17|P-value:9.78E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.56|P-value:3.78E-6 ID:SGTC_2783|Compound:7738165|FD-Score:4.74|P-value:1.65E-6 ID:SGTC_3211|Compound:9128781|FD-Score:3.97|P-value:5.08E-5

Top fitness defect scores for YMR294W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 7.11 100.0 µM 1.22E-12 redox potentiating 124 5.98E-13
2 SGTC_755 1995-0008 4.88 37.3 µM 8.11E-7 12 5.25E-7
3 SGTC_2783 7738165 4.74 71.4 µM 1.65E-6 14 1.08E-6
4 SGTC_1326 1431-2094 4.67 10.8 µM 2.28E-6 tubulin folding & SWR complex 22 1.51E-6
5 SGTC_1527 coumarin 4.59 137.0 µM 3.30E-6 11 2.21E-6
6 SGTC_2517 totarol 4.56 10.0 µM 3.73E-6 12 2.51E-6
7 SGTC_2782 7736369 4.56 71.4 µM 3.78E-6 19 2.54E-6
8 SGTC_1059 3448-6867 4.18 171.0 µM 2.05E-5 9 1.43E-5
9 SGTC_73 0327-0325 4.04 16.2 µM 3.71E-5 DNA damage response 48 2.63E-5
10 SGTC_1058 3448-5425 4.02 97.3 µM 4.12E-5 32 2.93E-5
11 SGTC_1371 2421-0008 4.01 32.7 µM 4.33E-5 mitochondrial processes 36 3.08E-5
12 SGTC_3211 9128781 3.97 49.5 µM 5.08E-5 56 3.63E-5
13 SGTC_1376 2910-0861 3.85 41.3 µM 8.04E-5 21 5.81E-5
14 SGTC_1511 0906-3109 3.82 28.5 µM 9.20E-5 excess fatty acid 54 6.67E-5
15 SGTC_2461 5755302 3.81 26.1 µM 9.72E-5 38 7.06E-5
16 SGTC_2105 5350118 3.75 200.0 µM 1.22E-4 32 8.94E-5
17 SGTC_1305 1181-0477 3.71 144.0 µM 1.42E-4 20 1.04E-4
18 SGTC_2617 dihydrotanshinone i 3.69 20.8 µM 1.55E-4 copper-dependent oxidative stress 55 1.14E-4
19 SGTC_1478 0453-0656 3.59 35.7 µM 2.22E-4 25 1.64E-4
20 SGTC_1663 st014140 3.59 55.4 µM 2.26E-4 60S ribosome export 24 1.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 4.01E-24 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.162 3.53E-21 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.160 8.97E-21 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.154 3.17E-19 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.149 3.78E-18 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.149 4.44E-18 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.139 7.38E-16 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.137 1.85E-15 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.136 2.66E-15 YGL001C ERG26 het C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
0.131 2.57E-14 YNR005C_d YNR005C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.130 3.74E-14 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.129 7.75E-14 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.126 2.19E-13 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.119 4.73E-12 YIL018W RPL2B hom Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures
0.118 7.74E-12 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress