YMR297W / PRC1

Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR297W / PRC1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.26|P-value:1.04E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-2.88|P-value:6.68E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:2.90|P-value:4.78E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.01|P-value:3.01E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-2.99|P-value:4.40E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:-3.73|P-value:1.59E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:2.77|P-value:8.07E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:2.97|P-value:3.57E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:2.94|P-value:4.09E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:2.83|P-value:6.40E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.73|P-value:9.43E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.78|P-value:8.92E-6 ID:SGTC_1073|Compound:triclabendazole|FD-Score:2.77|P-value:7.81E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.25|P-value:6.99E-7 ID:SGTC_1228|Compound:0124-0032|FD-Score:-2.82|P-value:8.54E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.48|P-value:3.83E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.80|P-value:7.19E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.77|P-value:1.26E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.02|P-value:2.49E-6 ID:SGTC_1637|Compound:st007924|FD-Score:-3.18|P-value:1.96E-4 ID:SGTC_1638|Compound:st008370|FD-Score:5.01|P-value:6.88E-9 ID:SGTC_1764|Compound:st044502|FD-Score:-2.88|P-value:6.83E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:2.96|P-value:3.78E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.34|P-value:7.18E-5 ID:SGTC_1937|Compound:st074714|FD-Score:3.76|P-value:9.55E-6 ID:SGTC_1970|Compound:st070122|FD-Score:2.84|P-value:6.04E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.16|P-value:1.58E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.44|P-value:6.28E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.76|P-value:9.52E-6 ID:SGTC_2178|Compound:5812956|FD-Score:-3.47|P-value:5.35E-5 ID:SGTC_2260|Compound:7964312|FD-Score:3.27|P-value:1.01E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.24|P-value:1.54E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.90|P-value:6.52E-6 ID:SGTC_2307|Compound:7538926|FD-Score:-3.11|P-value:2.64E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-10.50|P-value:1.82E-32 ID:SGTC_2314|Compound:7727897|FD-Score:-4.96|P-value:1.45E-8 ID:SGTC_2315|Compound:7733312|FD-Score:4.35|P-value:3.89E-7 ID:SGTC_2475|Compound:5812728|FD-Score:-3.14|P-value:2.38E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.89|P-value:6.87E-6 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.60|P-value:2.12E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.26|P-value:1.03E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.31|P-value:8.42E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.02|P-value:3.86E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-2.91|P-value:5.89E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:5.66|P-value:6.90E-11 ID:SGTC_2693|Compound:st077581|FD-Score:3.24|P-value:1.15E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-2.89|P-value:6.42E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-4.07|P-value:2.69E-6 ID:SGTC_2914|Compound:7968218|FD-Score:3.06|P-value:2.49E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.57|P-value:3.36E-5 ID:SGTC_20|Compound:0481-0013|FD-Score:3.26|P-value:1.04E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-2.88|P-value:6.68E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:2.90|P-value:4.78E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.01|P-value:3.01E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-2.99|P-value:4.40E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:-3.73|P-value:1.59E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:2.77|P-value:8.07E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:2.97|P-value:3.57E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:2.94|P-value:4.09E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:2.83|P-value:6.40E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.73|P-value:9.43E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.78|P-value:8.92E-6 ID:SGTC_1073|Compound:triclabendazole|FD-Score:2.77|P-value:7.81E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.25|P-value:6.99E-7 ID:SGTC_1228|Compound:0124-0032|FD-Score:-2.82|P-value:8.54E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.48|P-value:3.83E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.80|P-value:7.19E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.77|P-value:1.26E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.02|P-value:2.49E-6 ID:SGTC_1637|Compound:st007924|FD-Score:-3.18|P-value:1.96E-4 ID:SGTC_1638|Compound:st008370|FD-Score:5.01|P-value:6.88E-9 ID:SGTC_1764|Compound:st044502|FD-Score:-2.88|P-value:6.83E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:2.96|P-value:3.78E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.34|P-value:7.18E-5 ID:SGTC_1937|Compound:st074714|FD-Score:3.76|P-value:9.55E-6 ID:SGTC_1970|Compound:st070122|FD-Score:2.84|P-value:6.04E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.16|P-value:1.58E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.44|P-value:6.28E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.76|P-value:9.52E-6 ID:SGTC_2178|Compound:5812956|FD-Score:-3.47|P-value:5.35E-5 ID:SGTC_2260|Compound:7964312|FD-Score:3.27|P-value:1.01E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.24|P-value:1.54E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.90|P-value:6.52E-6 ID:SGTC_2307|Compound:7538926|FD-Score:-3.11|P-value:2.64E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-10.50|P-value:1.82E-32 ID:SGTC_2314|Compound:7727897|FD-Score:-4.96|P-value:1.45E-8 ID:SGTC_2315|Compound:7733312|FD-Score:4.35|P-value:3.89E-7 ID:SGTC_2475|Compound:5812728|FD-Score:-3.14|P-value:2.38E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.89|P-value:6.87E-6 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.60|P-value:2.12E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.26|P-value:1.03E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.31|P-value:8.42E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.02|P-value:3.86E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-2.91|P-value:5.89E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:5.66|P-value:6.90E-11 ID:SGTC_2693|Compound:st077581|FD-Score:3.24|P-value:1.15E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-2.89|P-value:6.42E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-4.07|P-value:2.69E-6 ID:SGTC_2914|Compound:7968218|FD-Score:3.06|P-value:2.49E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.57|P-value:3.36E-5

Top fitness defect scores for YMR297W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2686 alizarin 5.66 95.4 µM 6.90E-11 RPP1 & pyrimidine depletion 10 7.37E-9
2 SGTC_1638 st008370 5.01 60.6 µM 6.88E-9 ergosterol biosynthesis 13 2.78E-7
3 SGTC_2315 7733312 4.35 200.0 µM 3.89E-7 19 6.71E-6
4 SGTC_1082 camptothecin 4.25 424.9 nM 6.99E-7 DNA damage response 39 1.07E-5
5 SGTC_1636 st007707 4.02 68.9 µM 2.49E-6 48 2.92E-5
6 SGTC_1055 3448-0672 3.78 86.0 µM 8.92E-6 34 7.98E-5
7 SGTC_2115 tiliquinol 3.76 12.8 µM 9.52E-6 11 8.40E-5
8 SGTC_1937 st074714 3.76 47.2 µM 9.55E-6 47 8.43E-5
9 SGTC_2501 sodium tetradecyl sulfate 3.60 13.4 µM 2.12E-5 43 1.58E-4
10 SGTC_1232 0279-0259 3.48 161.0 µM 3.83E-5 39 2.53E-4
11 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.34 70.1 µM 7.18E-5 57 4.16E-4
12 SGTC_2504 purpurogallin 3.31 52.3 µM 8.42E-5 RPP1 & pyrimidine depletion 43 4.72E-4
13 SGTC_2260 7964312 3.27 200.0 µM 1.01E-4 32 5.47E-4
14 SGTC_2503 beta-caryophyllene alcohol 3.26 24.7 µM 1.03E-4 25 5.55E-4
15 SGTC_20 0481-0013 3.26 4.9 µM 1.04E-4 53 5.60E-4
16 SGTC_2693 st077581 3.24 40.7 µM 1.15E-4 70 6.03E-4
17 SGTC_1973 st070275 3.16 50.2 µM 1.58E-4 36 7.79E-4
18 SGTC_2914 7968218 3.06 45.3 µM 2.49E-4 31 0.00112
19 SGTC_73 0327-0325 3.01 16.2 µM 3.01E-4 DNA damage response 116 0.00130
20 SGTC_293 4049-0273 2.97 38.5 µM 3.57E-4 47 0.00148

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 3.49E-14 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.129 6.52E-14 YDL113C ATG20 hom Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
0.128 8.57E-14 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.124 6.64E-13 YGR234W YHB1 hom Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.123 9.28E-13 YFL010W-A AUA1 hom Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease
0.107 5.46E-10 YJR009C TDH2 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; TDH2 has a paralog, TDH3, that arose from the whole genome duplication
0.106 8.07E-10 YAL030W SNC1 hom Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication
0.105 1.02E-9 YJR034W PET191 hom Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery
0.102 3.55E-9 YGR013W SNU71 het Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart
0.095 4.09E-8 YPL271W ATP15 hom Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.093 7.12E-8 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.089 2.63E-7 YDR471W RPL27B hom Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication
0.088 3.35E-7 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.086 6.48E-7 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.085 8.85E-7 YOL158C ENB1 hom Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment