YMR317W_p

Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR317W / YMR317W

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.59|P-value:9.31E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:3.59|P-value:9.39E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:4.15|P-value:7.76E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.01|P-value:8.52E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.22|P-value:5.73E-6 ID:SGTC_470|Compound:aa-861|FD-Score:3.09|P-value:6.55E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.23|P-value:3.84E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:2.99|P-value:9.38E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.24|P-value:3.70E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-3.00|P-value:9.02E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.68|P-value:6.47E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.04|P-value:7.88E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.30|P-value:3.00E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.12|P-value:5.82E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.64|P-value:7.55E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.04|P-value:7.98E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.90|P-value:2.48E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.15|P-value:7.83E-6 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:5.12|P-value:5.01E-8 ID:SGTC_1868|Compound:st057644|FD-Score:5.34|P-value:1.38E-8 ID:SGTC_1990|Compound:st072050|FD-Score:3.02|P-value:8.57E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.24|P-value:3.71E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.00|P-value:9.16E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.00|P-value:9.04E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.42|P-value:1.84E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.43|P-value:1.79E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.12|P-value:5.96E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.78|P-value:4.24E-5 ID:SGTC_2459|Compound:5811157|FD-Score:-3.14|P-value:5.40E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.76|P-value:4.59E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.32|P-value:3.37E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:4.75|P-value:3.96E-7 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:5.85|P-value:5.84E-10 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.86|P-value:2.86E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.00|P-value:8.86E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.00|P-value:1.59E-5 ID:SGTC_2877|Compound:9040724|FD-Score:3.38|P-value:2.20E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.10|P-value:6.21E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.42|P-value:1.81E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.15|P-value:5.22E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.14|P-value:5.43E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-4.17|P-value:7.15E-6 ID:SGTC_3086|Compound:9117350|FD-Score:3.83|P-value:3.41E-5 ID:SGTC_3091|Compound:9116372|FD-Score:-3.34|P-value:2.56E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-3.52|P-value:1.24E-4 ID:SGTC_3121|Compound:9125696|FD-Score:-3.20|P-value:4.32E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.04|P-value:7.79E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.44|P-value:1.73E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:3.59|P-value:9.31E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:3.59|P-value:9.39E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:4.15|P-value:7.76E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.01|P-value:8.52E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.22|P-value:5.73E-6 ID:SGTC_470|Compound:aa-861|FD-Score:3.09|P-value:6.55E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.23|P-value:3.84E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:2.99|P-value:9.38E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.24|P-value:3.70E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-3.00|P-value:9.02E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.68|P-value:6.47E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.04|P-value:7.88E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.30|P-value:3.00E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.12|P-value:5.82E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.64|P-value:7.55E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.04|P-value:7.98E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.90|P-value:2.48E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.15|P-value:7.83E-6 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:5.12|P-value:5.01E-8 ID:SGTC_1868|Compound:st057644|FD-Score:5.34|P-value:1.38E-8 ID:SGTC_1990|Compound:st072050|FD-Score:3.02|P-value:8.57E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.24|P-value:3.71E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.00|P-value:9.16E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.00|P-value:9.04E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.42|P-value:1.84E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.43|P-value:1.79E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.12|P-value:5.96E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.78|P-value:4.24E-5 ID:SGTC_2459|Compound:5811157|FD-Score:-3.14|P-value:5.40E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.76|P-value:4.59E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.32|P-value:3.37E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:4.75|P-value:3.96E-7 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:5.85|P-value:5.84E-10 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.86|P-value:2.86E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.00|P-value:8.86E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.00|P-value:1.59E-5 ID:SGTC_2877|Compound:9040724|FD-Score:3.38|P-value:2.20E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.10|P-value:6.21E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.42|P-value:1.81E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.15|P-value:5.22E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.14|P-value:5.43E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-4.17|P-value:7.15E-6 ID:SGTC_3086|Compound:9117350|FD-Score:3.83|P-value:3.41E-5 ID:SGTC_3091|Compound:9116372|FD-Score:-3.34|P-value:2.56E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-3.52|P-value:1.24E-4 ID:SGTC_3121|Compound:9125696|FD-Score:-3.20|P-value:4.32E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.04|P-value:7.79E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.44|P-value:1.73E-4

Top fitness defect scores for YMR317W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2588 indole-3-carbinol 5.85 100.0 µM 5.84E-10 10 2.48E-9
2 SGTC_1868 st057644 5.34 42.7 µM 1.38E-8 15 4.64E-8
3 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 5.12 66.5 µM 5.01E-8 6 1.53E-7
4 SGTC_2586 curcumin 4.75 80.0 µM 3.96E-7 iron homeostasis 35 1.04E-6
5 SGTC_379 3970-0972 4.22 5.9 µM 5.73E-6 tubulin folding & SWR complex 31 1.23E-5
6 SGTC_139 0099-0334 4.15 718.6 µM 7.76E-6 22 1.63E-5
7 SGTC_1340 1486-1359 4.15 257.0 µM 7.83E-6 18 1.65E-5
8 SGTC_2858 9025781 4.00 9.0 µM 1.59E-5 sphingolipid biosynthesis & PDR1 97 3.18E-5
9 SGTC_3086 9117350 3.83 49.5 µM 3.41E-5 6 6.44E-5
10 SGTC_2420 aureobasidin a 3.78 50.0 nM 4.24E-5 51 7.88E-5
11 SGTC_2572 astragaloside iv 3.76 100.0 µM 4.59E-5 34 8.48E-5
12 SGTC_1092 toremifene 3.68 6.3 µM 6.47E-5 30 1.17E-4
13 SGTC_1221 2958-7315 3.64 257.0 µM 7.55E-5 23 1.35E-4
14 SGTC_1 0258-0098 3.59 57.4 µM 9.31E-5 heme biosynthesis & mitochondrial translocase 16 1.64E-4
15 SGTC_3 0833-0587 3.59 95.6 µM 9.39E-5 redox potentiating 31 1.65E-4
16 SGTC_3351 9150312 3.44 21.6 µM 1.73E-4 cell wall 50 2.90E-4
17 SGTC_2389 9091542 3.43 195.5 µM 1.79E-4 iron homeostasis 55 3.00E-4
18 SGTC_2827 7993847 3.43 71.4 µM 1.82E-4 40 3.04E-4
19 SGTC_2877 9040724 3.38 71.4 µM 2.20E-4 30 3.63E-4
20 SGTC_1217 1183-1422 3.30 255.0 µM 3.00E-4 31 4.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.78E-13 YBR259W YBR259W hom Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress
0.118 5.82E-12 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.115 2.33E-11 YNR071C_p YNR071C_p hom Putative aldose 1-epimerase
0.113 5.90E-11 YLR008C PAM18 het Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p
0.106 6.45E-10 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.102 3.42E-9 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.093 6.45E-8 YDR006C SOK1 hom Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
0.092 9.99E-8 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.089 2.29E-7 YKL079W SMY1 hom Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
0.088 3.54E-7 YDR340W_d YDR340W_d hom Putative protein of unknown function
0.085 9.13E-7 YKL069W YKL069W hom Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress
0.082 1.86E-6 YOR343C_d YOR343C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.53E-6 YLR251W SYM1 hom Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
0.080 3.51E-6 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.077 6.98E-6 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate