YMR318C / ADH6

NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR318C / ADH6

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.53|P-value:2.29E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.64|P-value:2.17E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.40|P-value:3.61E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.49|P-value:3.74E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:4.07|P-value:2.67E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:3.59|P-value:1.81E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.35|P-value:4.40E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.72|P-value:1.50E-6 ID:SGTC_638|Compound:3970-0837|FD-Score:4.16|P-value:1.87E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:4.01|P-value:3.47E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.11|P-value:9.87E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.28|P-value:5.62E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.45|P-value:3.01E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.75|P-value:9.82E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:4.00|P-value:3.58E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:3.59|P-value:1.79E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.80|P-value:8.00E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.65|P-value:1.46E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:5.85|P-value:3.69E-9 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.22|P-value:6.84E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.82|P-value:7.44E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.49|P-value:2.60E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:6.76|P-value:1.24E-11 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.66|P-value:1.97E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.15|P-value:8.69E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.30|P-value:5.20E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.23|P-value:6.56E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.28|P-value:7.56E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.05|P-value:2.98E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.45|P-value:3.05E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.00|P-value:3.64E-5 ID:SGTC_1959|Compound:st077091|FD-Score:5.65|P-value:1.16E-8 ID:SGTC_1991|Compound:st073000|FD-Score:3.54|P-value:2.22E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.33|P-value:1.35E-5 ID:SGTC_2011|Compound:4012611|FD-Score:3.32|P-value:4.74E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-4.03|P-value:4.71E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.46|P-value:2.90E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.60|P-value:1.77E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.73|P-value:1.07E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.16|P-value:8.42E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.67|P-value:1.32E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.31|P-value:4.98E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.28|P-value:5.56E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-4.15|P-value:2.83E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.85|P-value:6.70E-5 ID:SGTC_3070|Compound:9117005|FD-Score:-3.62|P-value:2.34E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.11|P-value:3.36E-5 ID:SGTC_3277|Compound:9138724|FD-Score:6.35|P-value:1.74E-10 ID:SGTC_21|Compound:0849-0113|FD-Score:3.53|P-value:2.29E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.64|P-value:2.17E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.40|P-value:3.61E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.49|P-value:3.74E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:4.07|P-value:2.67E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:3.59|P-value:1.81E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.35|P-value:4.40E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.72|P-value:1.50E-6 ID:SGTC_638|Compound:3970-0837|FD-Score:4.16|P-value:1.87E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:4.01|P-value:3.47E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.11|P-value:9.87E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.28|P-value:5.62E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.45|P-value:3.01E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.75|P-value:9.82E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:4.00|P-value:3.58E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:3.59|P-value:1.79E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.80|P-value:8.00E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.65|P-value:1.46E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:5.85|P-value:3.69E-9 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.22|P-value:6.84E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.82|P-value:7.44E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.49|P-value:2.60E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:6.76|P-value:1.24E-11 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.66|P-value:1.97E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.15|P-value:8.69E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.30|P-value:5.20E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.23|P-value:6.56E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.28|P-value:7.56E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.05|P-value:2.98E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.45|P-value:3.05E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.00|P-value:3.64E-5 ID:SGTC_1959|Compound:st077091|FD-Score:5.65|P-value:1.16E-8 ID:SGTC_1991|Compound:st073000|FD-Score:3.54|P-value:2.22E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.33|P-value:1.35E-5 ID:SGTC_2011|Compound:4012611|FD-Score:3.32|P-value:4.74E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-4.03|P-value:4.71E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.46|P-value:2.90E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.60|P-value:1.77E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.73|P-value:1.07E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.16|P-value:8.42E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.67|P-value:1.32E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.31|P-value:4.98E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.28|P-value:5.56E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-4.15|P-value:2.83E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.85|P-value:6.70E-5 ID:SGTC_3070|Compound:9117005|FD-Score:-3.62|P-value:2.34E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.11|P-value:3.36E-5 ID:SGTC_3277|Compound:9138724|FD-Score:6.35|P-value:1.74E-10

Top fitness defect scores for YMR318C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1056 3448-1962 6.76 115.0 µM 1.24E-11 amide catabolism 3 6.84E-12
2 SGTC_3277 9138724 6.35 49.5 µM 1.74E-10 Golgi 7 1.05E-10
3 SGTC_1010 4112-3296 5.85 15.2 µM 3.69E-9 6 2.45E-9
4 SGTC_1959 st077091 5.65 55.8 µM 1.16E-8 RPP1 & pyrimidine depletion 13 7.96E-9
5 SGTC_635 k038-0028 4.72 24.7 µM 1.50E-6 ubiquinone biosynthesis & proteasome 33 1.20E-6
6 SGTC_638 3970-0837 4.16 4.1 µM 1.87E-5 31 1.60E-5
7 SGTC_334 1502-1024 4.07 68.5 µM 2.67E-5 11 2.31E-5
8 SGTC_1247 0448-0043 4.05 5.8 µM 2.98E-5 ERG2 38 2.59E-5
9 SGTC_654 1124-0271 4.01 80.9 µM 3.47E-5 20 3.03E-5
10 SGTC_929 2805-0021 4.00 398.0 µM 3.58E-5 14 3.13E-5
11 SGTC_1418 3966-3099 4.00 2.4 µM 3.64E-5 15 3.18E-5
12 SGTC_2807 7945238 3.85 52.0 µM 6.70E-5 26 5.95E-5
13 SGTC_1018 4259-0013 3.82 28.1 µM 7.44E-5 25 6.62E-5
14 SGTC_942 3253-1115 3.80 227.0 µM 8.00E-5 32 7.14E-5
15 SGTC_926 2268-1401 3.75 59.4 µM 9.82E-5 TSC3-RPN4 35 8.81E-5
16 SGTC_2451 5856223 3.73 45.7 µM 1.07E-4 28 9.58E-5
17 SGTC_2536 dehydroabietamide 3.67 32.0 µM 1.32E-4 46 1.19E-4
18 SGTC_948 3448-0295 3.65 75.3 µM 1.46E-4 39 1.32E-4
19 SGTC_2174 5790901 3.60 200.0 µM 1.77E-4 tubulin folding & SWR complex 44 1.62E-4
20 SGTC_932 2857-0803 3.59 154.0 µM 1.79E-4 37 1.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.14E-8 YBL055C YBL055C hom 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
0.088 3.43E-7 YBR285W_p YBR285W_p hom Putative protein of unknown function; YBR285W is not an essential gene
0.084 1.08E-6 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.082 2.22E-6 YBR210W ERV15 hom Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication
0.081 2.33E-6 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.081 2.91E-6 YKL052C ASK1 het Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress
0.080 4.03E-6 YGR142W BTN2 hom v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication
0.077 7.78E-6 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.077 7.80E-6 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.075 1.54E-5 YOL149W DCP1 het Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
0.074 1.68E-5 YLL024C SSA2 hom ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes
0.074 1.72E-5 YPL048W CAM1 hom Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma
0.072 2.85E-5 YHR140W_p YHR140W_p hom Putative integral membrane protein of unknown function
0.072 3.32E-5 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.072 3.32E-5 YLR247C IRC20 hom Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci