YMR322C_p / SNO4

Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR322C / SNO4

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:3.88|P-value:3.12E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.92|P-value:3.36E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-2.72|P-value:7.75E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.27|P-value:3.29E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:2.81|P-value:5.28E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:2.83|P-value:4.83E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:2.77|P-value:6.21E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:2.81|P-value:5.28E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.08|P-value:1.64E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.33|P-value:8.35E-14 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.26|P-value:1.62E-13 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.22|P-value:9.14E-5 ID:SGTC_1630|Compound:st005209|FD-Score:2.91|P-value:3.45E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.32|P-value:5.62E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.31|P-value:5.78E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:4.06|P-value:1.11E-6 ID:SGTC_2491|Compound:paeonol|FD-Score:4.67|P-value:2.68E-8 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.97|P-value:1.85E-6 ID:SGTC_2493|Compound:resveratrol|FD-Score:5.49|P-value:7.62E-11 ID:SGTC_2563|Compound:tomatine|FD-Score:2.91|P-value:3.52E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-2.67|P-value:9.62E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.96|P-value:2.86E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.23|P-value:8.12E-5 ID:SGTC_2692|Compound:st077426|FD-Score:5.95|P-value:2.04E-12 ID:SGTC_2848|Compound:9016370|FD-Score:3.97|P-value:1.83E-6 ID:SGTC_2852|Compound:9023854|FD-Score:3.32|P-value:5.52E-5 ID:SGTC_2859|Compound:9028643|FD-Score:2.97|P-value:2.62E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.51|P-value:2.21E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.95|P-value:2.05E-6 ID:SGTC_2969|Compound:9091408|FD-Score:4.03|P-value:1.31E-6 ID:SGTC_2970|Compound:9090938|FD-Score:4.92|P-value:4.88E-9 ID:SGTC_3031|Compound:9088762|FD-Score:-2.92|P-value:3.39E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.51|P-value:2.12E-5 ID:SGTC_3300|Compound:9124615|FD-Score:4.53|P-value:6.39E-8 ID:SGTC_67|Compound:0335-0847|FD-Score:3.88|P-value:3.12E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.92|P-value:3.36E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-2.72|P-value:7.75E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.27|P-value:3.29E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:2.81|P-value:5.28E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:2.83|P-value:4.83E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:2.77|P-value:6.21E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:2.81|P-value:5.28E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.08|P-value:1.64E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.33|P-value:8.35E-14 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.26|P-value:1.62E-13 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.22|P-value:9.14E-5 ID:SGTC_1630|Compound:st005209|FD-Score:2.91|P-value:3.45E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.32|P-value:5.62E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.31|P-value:5.78E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:4.06|P-value:1.11E-6 ID:SGTC_2491|Compound:paeonol|FD-Score:4.67|P-value:2.68E-8 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.97|P-value:1.85E-6 ID:SGTC_2493|Compound:resveratrol|FD-Score:5.49|P-value:7.62E-11 ID:SGTC_2563|Compound:tomatine|FD-Score:2.91|P-value:3.52E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-2.67|P-value:9.62E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.96|P-value:2.86E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.23|P-value:8.12E-5 ID:SGTC_2692|Compound:st077426|FD-Score:5.95|P-value:2.04E-12 ID:SGTC_2848|Compound:9016370|FD-Score:3.97|P-value:1.83E-6 ID:SGTC_2852|Compound:9023854|FD-Score:3.32|P-value:5.52E-5 ID:SGTC_2859|Compound:9028643|FD-Score:2.97|P-value:2.62E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.51|P-value:2.21E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.95|P-value:2.05E-6 ID:SGTC_2969|Compound:9091408|FD-Score:4.03|P-value:1.31E-6 ID:SGTC_2970|Compound:9090938|FD-Score:4.92|P-value:4.88E-9 ID:SGTC_3031|Compound:9088762|FD-Score:-2.92|P-value:3.39E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.51|P-value:2.12E-5 ID:SGTC_3300|Compound:9124615|FD-Score:4.53|P-value:6.39E-8

Top fitness defect scores for YMR322C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2692 st077426 5.95 47.7 µM 2.04E-12 5 1.33E-9
2 SGTC_2493 resveratrol 5.49 26.1 µM 7.62E-11 1 1.96E-8
3 SGTC_2970 9090938 4.92 41.9 µM 4.88E-9 RNA processing & uracil transport 12 4.32E-7
4 SGTC_2491 paeonol 4.67 100.0 µM 2.68E-8 3 1.53E-6
5 SGTC_3300 9124615 4.53 50.5 µM 6.39E-8 11 2.93E-6
6 SGTC_2490 carminic acid 4.06 95.4 µM 1.11E-6 6 2.46E-5
7 SGTC_2969 9091408 4.03 28.7 µM 1.31E-6 25 2.78E-5
8 SGTC_2848 9016370 3.97 26.0 µM 1.83E-6 22 3.57E-5
9 SGTC_2492 derrusnin 3.97 100.0 µM 1.85E-6 3 3.60E-5
10 SGTC_2935 9038016 3.95 30.0 µM 2.05E-6 21 3.89E-5
11 SGTC_67 0335-0847 3.88 266.0 µM 3.12E-6 ubiquinone biosynthesis & proteasome 123 5.32E-5
12 SGTC_3042 9091578 3.51 49.5 µM 2.12E-5 ERG2 7 2.22E-4
13 SGTC_2852 9023854 3.32 52.0 µM 5.52E-5 45 4.56E-4
14 SGTC_2335 9018011 3.31 154.2 µM 5.78E-5 47 4.72E-4
15 SGTC_2691 st077356 3.23 60.2 µM 8.12E-5 65 6.10E-4
16 SGTC_1061 3448-9325 3.08 110.0 µM 1.64E-4 50 0.00104
17 SGTC_2859 9028643 2.97 45.5 µM 2.62E-4 48 0.00147
18 SGTC_1630 st005209 2.91 31.3 µM 3.45E-4 87 0.00181
19 SGTC_2563 tomatine 2.91 8.5 µM 3.52E-4 121 0.00183
20 SGTC_827 3253-0474 2.83 693.0 µM 4.83E-4 74 0.00233

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.314 1.59E-77 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.305 3.47E-73 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.300 8.76E-71 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.293 1.22E-67 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.288 4.40E-65 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.282 3.59E-62 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.281 8.69E-62 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.259 1.59E-52 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.259 2.32E-52 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.251 1.90E-49 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.240 2.33E-45 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.237 3.42E-44 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.235 3.20E-43 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.234 5.34E-43 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.232 2.45E-42 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension