YNL011C_p

Putative protein of unknown function; YNL011C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL011C / YNL011C

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.53|P-value:3.22E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:3.13|P-value:1.89E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:-2.89|P-value:7.98E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-2.84|P-value:9.78E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.19|P-value:1.49E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.24|P-value:1.22E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.32|P-value:8.32E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.17|P-value:2.66E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-4.23|P-value:1.73E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:4.03|P-value:2.60E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:4.26|P-value:7.42E-7 ID:SGTC_996|Compound:3970-0799|FD-Score:3.40|P-value:5.88E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:2.72|P-value:9.91E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.02|P-value:5.06E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.77|P-value:8.09E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.40|P-value:5.72E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:2.99|P-value:3.37E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.13|P-value:1.92E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.95|P-value:4.08E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.45|P-value:8.05E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.29|P-value:9.76E-5 ID:SGTC_2103|Compound:5378138|FD-Score:3.20|P-value:1.40E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.89|P-value:1.77E-8 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.53|P-value:3.13E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.72|P-value:1.07E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.31|P-value:1.49E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.41|P-value:9.71E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:2.86|P-value:5.69E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.65|P-value:1.78E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.22|P-value:2.17E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.94|P-value:4.24E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.81|P-value:2.91E-8 ID:SGTC_41|Compound:0478-0632|FD-Score:3.53|P-value:3.22E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:3.13|P-value:1.89E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:-2.89|P-value:7.98E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-2.84|P-value:9.78E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.19|P-value:1.49E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.24|P-value:1.22E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.32|P-value:8.32E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.17|P-value:2.66E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-4.23|P-value:1.73E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:4.03|P-value:2.60E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:4.26|P-value:7.42E-7 ID:SGTC_996|Compound:3970-0799|FD-Score:3.40|P-value:5.88E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:2.72|P-value:9.91E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.02|P-value:5.06E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.77|P-value:8.09E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.40|P-value:5.72E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:2.99|P-value:3.37E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.13|P-value:1.92E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.95|P-value:4.08E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.45|P-value:8.05E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.29|P-value:9.76E-5 ID:SGTC_2103|Compound:5378138|FD-Score:3.20|P-value:1.40E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.89|P-value:1.77E-8 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.53|P-value:3.13E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.72|P-value:1.07E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.31|P-value:1.49E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.41|P-value:9.71E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:2.86|P-value:5.69E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.65|P-value:1.78E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.22|P-value:2.17E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.94|P-value:4.24E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.81|P-value:2.91E-8

Top fitness defect scores for YNL011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2126 5251174 4.89 33.9 µM 1.77E-8 10 5.03E-7
2 SGTC_2693 st077581 4.81 40.7 µM 2.91E-8 16 7.49E-7
3 SGTC_988 1497-1057 4.26 103.0 µM 7.42E-7 7 1.01E-5
4 SGTC_987 1497-1013 4.03 404.0 µM 2.60E-6 11 2.76E-5
5 SGTC_2608 thymoquinone 3.65 42.7 µM 1.78E-5 26 1.29E-4
6 SGTC_2130 NSC 7 3.53 2.5 µM 3.13E-5 copper-dependent oxidative stress 46 2.04E-4
7 SGTC_41 0478-0632 3.53 82.6 µM 3.22E-5 42 2.09E-4
8 SGTC_1246 0422-0085 3.40 105.0 µM 5.72E-5 57 3.31E-4
9 SGTC_996 3970-0799 3.40 1.8 µM 5.88E-5 122 3.38E-4
10 SGTC_669 0108-0021 3.32 26.2 µM 8.32E-5 fatty acid desaturase (OLE1) 126 4.47E-4
11 SGTC_1988 st071872 3.29 53.4 µM 9.76E-5 23 5.08E-4
12 SGTC_454 lyso-paf C-16 3.24 6.7 µM 1.22E-4 45 6.08E-4
13 SGTC_2103 5378138 3.20 10.0 µM 1.40E-4 46 6.81E-4
14 SGTC_449 xestospongin c 3.19 11.2 µM 1.49E-4 NEO1-PIK1 112 7.16E-4
15 SGTC_299 1273-0059 3.13 1.4 µM 1.89E-4 52 8.67E-4
16 SGTC_1270 0831-1170 3.13 17.3 µM 1.92E-4 36 8.75E-4
17 SGTC_1248 0469-0687 2.99 58.6 µM 3.37E-4 81 0.00138
18 SGTC_1383 3049-0032 2.95 20.7 µM 4.08E-4 60S ribosome export 52 0.00161
19 SGTC_2692 st077426 2.94 47.7 µM 4.24E-4 72 0.00166
20 SGTC_2605 digitonin 2.86 300.0 nM 5.69E-4 98 0.00210

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.338 2.82E-90 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.290 3.10E-66 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.237 5.98E-44 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.228 9.41E-41 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.224 1.60E-39 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.224 2.80E-39 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.222 9.16E-39 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.220 3.53E-38 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.203 2.39E-32 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.199 3.74E-31 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.198 6.14E-31 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.197 9.11E-31 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.190 1.06E-28 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.189 1.89E-28 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.185 2.51E-27 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication