YNL013C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL013C / YNL013C

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-4.84|P-value:3.24E-8 ID:SGTC_150|Compound:3970-0969|FD-Score:2.99|P-value:4.02E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.39|P-value:7.18E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.18|P-value:1.38E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:4.08|P-value:2.47E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:3.28|P-value:1.21E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:2.96|P-value:4.45E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.38|P-value:7.63E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.48|P-value:4.84E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.18|P-value:1.91E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:2.91|P-value:5.45E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.95|P-value:4.70E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.51|P-value:4.34E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:4.53|P-value:1.98E-7 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.15|P-value:2.16E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-2.99|P-value:4.26E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-5.12|P-value:5.42E-9 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:2.77|P-value:9.57E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.15|P-value:2.16E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.84|P-value:7.14E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.68|P-value:1.90E-5 ID:SGTC_1635|Compound:st007035|FD-Score:2.92|P-value:5.38E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.53|P-value:4.07E-5 ID:SGTC_1851|Compound:st056236|FD-Score:3.08|P-value:2.77E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-5.02|P-value:1.04E-8 ID:SGTC_1915|Compound:st067105|FD-Score:-3.05|P-value:3.28E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.02|P-value:3.69E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.70|P-value:1.73E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.24|P-value:1.41E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-2.96|P-value:4.66E-4 ID:SGTC_2287|Compound:7945887|FD-Score:2.84|P-value:7.35E-4 ID:SGTC_2317|Compound:5986382|FD-Score:2.81|P-value:8.23E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.16|P-value:2.06E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.13|P-value:2.40E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.82|P-value:7.89E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.28|P-value:1.21E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.87|P-value:7.27E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:2.96|P-value:4.46E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-6.52|P-value:1.53E-13 ID:SGTC_2625|Compound:euphol|FD-Score:3.48|P-value:4.77E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:2.91|P-value:5.48E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.11|P-value:2.43E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-4.28|P-value:8.86E-7 ID:SGTC_3093|Compound:9117344|FD-Score:-3.40|P-value:7.45E-5 ID:SGTC_3094|Compound:9117742|FD-Score:-3.41|P-value:7.00E-5 ID:SGTC_3145|Compound:9085516|FD-Score:4.02|P-value:3.26E-6 ID:SGTC_3207|Compound:9114163|FD-Score:4.71|P-value:6.69E-8 ID:SGTC_3337|Compound:9144342|FD-Score:3.09|P-value:2.68E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.84|P-value:3.24E-8 ID:SGTC_150|Compound:3970-0969|FD-Score:2.99|P-value:4.02E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.39|P-value:7.18E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.18|P-value:1.38E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:4.08|P-value:2.47E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:3.28|P-value:1.21E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:2.96|P-value:4.45E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.38|P-value:7.63E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.48|P-value:4.84E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.18|P-value:1.91E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:2.91|P-value:5.45E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.95|P-value:4.70E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.51|P-value:4.34E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:4.53|P-value:1.98E-7 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.15|P-value:2.16E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-2.99|P-value:4.26E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-5.12|P-value:5.42E-9 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:2.77|P-value:9.57E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.15|P-value:2.16E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.84|P-value:7.14E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.68|P-value:1.90E-5 ID:SGTC_1635|Compound:st007035|FD-Score:2.92|P-value:5.38E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.53|P-value:4.07E-5 ID:SGTC_1851|Compound:st056236|FD-Score:3.08|P-value:2.77E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-5.02|P-value:1.04E-8 ID:SGTC_1915|Compound:st067105|FD-Score:-3.05|P-value:3.28E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.02|P-value:3.69E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.70|P-value:1.73E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.24|P-value:1.41E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-2.96|P-value:4.66E-4 ID:SGTC_2287|Compound:7945887|FD-Score:2.84|P-value:7.35E-4 ID:SGTC_2317|Compound:5986382|FD-Score:2.81|P-value:8.23E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.16|P-value:2.06E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.13|P-value:2.40E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.82|P-value:7.89E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.28|P-value:1.21E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.87|P-value:7.27E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:2.96|P-value:4.46E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-6.52|P-value:1.53E-13 ID:SGTC_2625|Compound:euphol|FD-Score:3.48|P-value:4.77E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:2.91|P-value:5.48E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.11|P-value:2.43E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-4.28|P-value:8.86E-7 ID:SGTC_3093|Compound:9117344|FD-Score:-3.40|P-value:7.45E-5 ID:SGTC_3094|Compound:9117742|FD-Score:-3.41|P-value:7.00E-5 ID:SGTC_3145|Compound:9085516|FD-Score:4.02|P-value:3.26E-6 ID:SGTC_3207|Compound:9114163|FD-Score:4.71|P-value:6.69E-8 ID:SGTC_3337|Compound:9144342|FD-Score:3.09|P-value:2.68E-4

Top fitness defect scores for YNL013C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3207 9114163 4.71 49.5 µM 6.69E-8 12 1.25E-6
2 SGTC_940 3232-1287 4.53 54.8 µM 1.98E-7 NEO1 21 3.00E-6
3 SGTC_421 streptovitacin 4.18 30.0 mM 1.38E-6 17 1.43E-5
4 SGTC_551 k048-0028 4.08 34.9 µM 2.47E-6 12 2.29E-5
5 SGTC_3145 9085516 4.02 49.5 µM 3.26E-6 fatty acid desaturase (OLE1) 27 2.86E-5
6 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.87 3.7 µM 7.27E-6 89 5.46E-5
7 SGTC_1948 st076329 3.70 66.6 µM 1.73E-5 38 1.10E-4
8 SGTC_1591 genipin 3.68 88.4 µM 1.90E-5 mitochondrial processes 19 1.18E-4
9 SGTC_2625 euphol 3.48 100.0 µM 4.77E-5 44 2.49E-4
10 SGTC_769 0302-0231 3.48 76.0 µM 4.84E-5 67 2.52E-4
11 SGTC_379 3970-0972 3.39 5.9 µM 7.18E-5 tubulin folding & SWR complex 56 3.47E-4
12 SGTC_761 k216-0224 3.38 480.0 µM 7.63E-5 45 3.64E-4
13 SGTC_2492 derrusnin 3.28 100.0 µM 1.21E-4 16 5.28E-4
14 SGTC_617 3770-0098 3.28 35.0 µM 1.21E-4 exosome 34 5.28E-4
15 SGTC_2002 4023503 3.24 131.0 µM 1.41E-4 mitochondrial processes 67 5.97E-4
16 SGTC_2949 9072542 3.11 2.2 µM 2.43E-4 TSC3-RPN4 84 9.30E-4
17 SGTC_3337 9144342 3.09 33.5 µM 2.68E-4 55 0.00100
18 SGTC_1851 st056236 3.08 18.9 µM 2.77E-4 47 0.00103
19 SGTC_150 3970-0969 2.99 77.2 µM 4.02E-4 126 0.00140
20 SGTC_644 1498-1197 2.96 63.3 µM 4.45E-4 76 0.00152

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 3.77E-23 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.156 1.15E-19 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.147 9.61E-18 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.133 1.08E-14 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.122 1.24E-12 YPR117W_p YPR117W_p hom Putative protein of unknown function
0.121 2.04E-12 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.119 3.94E-12 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.115 2.79E-11 YLL042C ATG10 hom Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy
0.114 3.34E-11 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.111 1.36E-10 YNL046W_p YNL046W_p hom Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.105 1.20E-9 YDR384C ATO3 hom Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
0.104 1.39E-9 YLR136C TIS11 hom mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.102 2.82E-9 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.102 3.48E-9 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
0.102 3.68E-9 YDR357C_p CNL1_p hom Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm