YNL020C / ARK1

Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL020C / ARK1

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.11|P-value:4.08E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:-2.88|P-value:7.45E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-2.87|P-value:7.73E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.22|P-value:2.63E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:3.80|P-value:2.10E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:3.78|P-value:2.35E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:3.14|P-value:3.67E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:5.93|P-value:6.97E-11 ID:SGTC_702|Compound:1488-0190|FD-Score:3.32|P-value:1.76E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-2.88|P-value:7.50E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.07|P-value:3.68E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.74|P-value:2.75E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:2.90|P-value:9.23E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:2.92|P-value:8.54E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:2.99|P-value:6.40E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.50|P-value:5.91E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.10|P-value:1.75E-8 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.40|P-value:9.38E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.71|P-value:2.31E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.89|P-value:4.08E-8 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.40|P-value:9.96E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.01|P-value:5.96E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-3.12|P-value:3.03E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.00|P-value:6.25E-4 ID:SGTC_1891|Compound:st059073|FD-Score:-3.19|P-value:2.20E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-2.86|P-value:8.00E-4 ID:SGTC_2032|Compound:5185112|FD-Score:2.96|P-value:7.25E-4 ID:SGTC_2045|Compound:5106652|FD-Score:2.97|P-value:7.07E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.06|P-value:5.02E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.33|P-value:1.24E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.49|P-value:8.50E-5 ID:SGTC_2301|Compound:7769476|FD-Score:3.42|P-value:1.15E-4 ID:SGTC_2303|Compound:7774051|FD-Score:2.96|P-value:7.26E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.31|P-value:1.84E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-2.87|P-value:7.83E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.22|P-value:2.65E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.89|P-value:9.38E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-2.86|P-value:8.17E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.07|P-value:3.69E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.06|P-value:5.01E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.50|P-value:8.15E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.16|P-value:2.51E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-4.05|P-value:4.31E-6 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-4.18|P-value:2.24E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.13|P-value:2.88E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.14|P-value:3.95E-6 ID:SGTC_2570|Compound:licareol|FD-Score:-5.11|P-value:1.09E-8 ID:SGTC_2646|Compound:retinol|FD-Score:3.66|P-value:4.03E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.50|P-value:8.18E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.09|P-value:3.37E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.68|P-value:2.61E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-4.03|P-value:4.82E-6 ID:SGTC_2973|Compound:9094665|FD-Score:-3.96|P-value:6.75E-6 ID:SGTC_3146|Compound:9095609|FD-Score:2.99|P-value:6.62E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.71|P-value:2.29E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-4.62|P-value:2.06E-7 ID:SGTC_3299|Compound:9121982|FD-Score:3.53|P-value:7.24E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:3.11|P-value:4.08E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:-2.88|P-value:7.45E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-2.87|P-value:7.73E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.22|P-value:2.63E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:3.80|P-value:2.10E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:3.78|P-value:2.35E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:3.14|P-value:3.67E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:5.93|P-value:6.97E-11 ID:SGTC_702|Compound:1488-0190|FD-Score:3.32|P-value:1.76E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-2.88|P-value:7.50E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.07|P-value:3.68E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.74|P-value:2.75E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:2.90|P-value:9.23E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:2.92|P-value:8.54E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:2.99|P-value:6.40E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.50|P-value:5.91E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.10|P-value:1.75E-8 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.40|P-value:9.38E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.71|P-value:2.31E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.89|P-value:4.08E-8 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.40|P-value:9.96E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.01|P-value:5.96E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-3.12|P-value:3.03E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.00|P-value:6.25E-4 ID:SGTC_1891|Compound:st059073|FD-Score:-3.19|P-value:2.20E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-2.86|P-value:8.00E-4 ID:SGTC_2032|Compound:5185112|FD-Score:2.96|P-value:7.25E-4 ID:SGTC_2045|Compound:5106652|FD-Score:2.97|P-value:7.07E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.06|P-value:5.02E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.33|P-value:1.24E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.49|P-value:8.50E-5 ID:SGTC_2301|Compound:7769476|FD-Score:3.42|P-value:1.15E-4 ID:SGTC_2303|Compound:7774051|FD-Score:2.96|P-value:7.26E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.31|P-value:1.84E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-2.87|P-value:7.83E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.22|P-value:2.65E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.89|P-value:9.38E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-2.86|P-value:8.17E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.07|P-value:3.69E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.06|P-value:5.01E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.50|P-value:8.15E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.16|P-value:2.51E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-4.05|P-value:4.31E-6 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-4.18|P-value:2.24E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.13|P-value:2.88E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.14|P-value:3.95E-6 ID:SGTC_2570|Compound:licareol|FD-Score:-5.11|P-value:1.09E-8 ID:SGTC_2646|Compound:retinol|FD-Score:3.66|P-value:4.03E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.50|P-value:8.18E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.09|P-value:3.37E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.68|P-value:2.61E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-4.03|P-value:4.82E-6 ID:SGTC_2973|Compound:9094665|FD-Score:-3.96|P-value:6.75E-6 ID:SGTC_3146|Compound:9095609|FD-Score:2.99|P-value:6.62E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.71|P-value:2.29E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-4.62|P-value:2.06E-7 ID:SGTC_3299|Compound:9121982|FD-Score:3.53|P-value:7.24E-5

Top fitness defect scores for YNL020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_695 3505-6186 5.93 243.0 µM 6.97E-11 3 1.50E-9
2 SGTC_1113 artemisinin 5.10 1.2 µM 1.75E-8 heme biosynthesis & mitochondrial translocase 8 1.68E-7
3 SGTC_1280 0880-0253 4.40 10.1 µM 9.96E-7 8 5.31E-6
4 SGTC_150 3970-0969 4.22 77.2 µM 2.63E-6 53 1.22E-5
5 SGTC_2563 tomatine 4.14 8.5 µM 3.95E-6 40 1.73E-5
6 SGTC_156 3474-0145 3.80 5.6 µM 2.10E-5 endomembrane recycling 55 7.26E-5
7 SGTC_188 3229-0966 3.78 278.5 µM 2.35E-5 29 7.99E-5
8 SGTC_784 4579-0127 3.74 173.0 µM 2.75E-5 28 9.16E-5
9 SGTC_2646 retinol 3.66 96.8 µM 4.03E-5 18 1.27E-4
10 SGTC_3299 9121982 3.53 43.1 µM 7.24E-5 43 2.10E-4
11 SGTC_2464 5717415 3.50 7.7 µM 8.15E-5 26 2.33E-4
12 SGTC_2769 toremifene 3.50 3.7 µM 8.18E-5 35 2.33E-4
13 SGTC_2202 7226349 3.49 200.0 µM 8.50E-5 18 2.41E-4
14 SGTC_2301 7769476 3.42 200.0 µM 1.15E-4 32 3.14E-4
15 SGTC_702 1488-0190 3.32 94.0 µM 1.76E-4 amide catabolism 32 4.51E-4
16 SGTC_2308 7584454 3.31 197.6 µM 1.84E-4 50 4.68E-4
17 SGTC_2341 7987486 3.22 176.7 µM 2.65E-4 44 6.42E-4
18 SGTC_621 3584-0052 3.14 32.1 µM 3.67E-4 49 8.51E-4
19 SGTC_25 0118-0223 3.11 35.7 µM 4.08E-4 52 9.32E-4
20 SGTC_2429 5902844 3.06 64.4 µM 5.01E-4 77 0.00111

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 7.03E-10 YGL243W TAD1 hom tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
0.102 3.83E-9 YDL211C_p YDL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.100 7.10E-9 YDR487C RIB3 het 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
0.098 1.23E-8 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.097 1.96E-8 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.095 3.89E-8 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.087 4.03E-7 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.086 5.96E-7 YLR088W GAA1 het Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER
0.080 3.23E-6 YGR225W AMA1 hom Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis
0.078 6.12E-6 YBR089W_d YBR089W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30
0.077 7.70E-6 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.077 8.75E-6 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.077 8.83E-6 YGL184C STR3 hom Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p
0.076 1.14E-5 YDR182W CDC1 het Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution
0.076 1.16E-5 YGR265W_d YGR265W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase