YNL023C / FAP1

Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL023C / FAP1

Click on Significant Values for Screen Details ID:SGTC_81|Compound:0411-0046|FD-Score:3.21|P-value:1.27E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:2.81|P-value:6.92E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.23|P-value:1.18E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:2.98|P-value:3.43E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.01|P-value:3.05E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:2.82|P-value:6.57E-4 ID:SGTC_223|Compound:busulfan|FD-Score:-3.68|P-value:1.19E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:4.22|P-value:7.14E-7 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.08|P-value:1.98E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.59|P-value:1.86E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.18|P-value:1.46E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.94|P-value:3.52E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:5.13|P-value:2.38E-9 ID:SGTC_762|Compound:1165-0429|FD-Score:3.00|P-value:3.11E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-2.85|P-value:5.21E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.68|P-value:1.34E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.62|P-value:1.62E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:-4.33|P-value:3.37E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.91|P-value:1.03E-8 ID:SGTC_1244|Compound:0416-0015|FD-Score:2.97|P-value:3.58E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.92|P-value:3.93E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:2.96|P-value:3.63E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.65|P-value:1.60E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-2.98|P-value:3.09E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.25|P-value:1.05E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.40|P-value:4.66E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-3.83|P-value:5.50E-6 ID:SGTC_1791|Compound:st048313|FD-Score:-3.02|P-value:2.58E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.39|P-value:4.92E-5 ID:SGTC_1885|Compound:st057546|FD-Score:4.28|P-value:5.21E-7 ID:SGTC_1891|Compound:st059073|FD-Score:4.49|P-value:1.48E-7 ID:SGTC_1904|Compound:st060225|FD-Score:-3.97|P-value:2.60E-6 ID:SGTC_1978|Compound:st071761|FD-Score:-2.72|P-value:8.81E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.77|P-value:7.35E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.74|P-value:8.53E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.98|P-value:3.09E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.58|P-value:2.20E-5 ID:SGTC_2692|Compound:st077426|FD-Score:2.72|P-value:9.72E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.69|P-value:1.27E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-2.86|P-value:5.04E-4 ID:SGTC_2806|Compound:7952793|FD-Score:2.87|P-value:5.47E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.91|P-value:4.07E-6 ID:SGTC_2968|Compound:9090663|FD-Score:-3.73|P-value:9.14E-6 ID:SGTC_2975|Compound:9084847|FD-Score:-4.57|P-value:7.60E-8 ID:SGTC_3005|Compound:9076496|FD-Score:-3.04|P-value:2.39E-4 ID:SGTC_3070|Compound:9117005|FD-Score:-3.80|P-value:6.20E-6 ID:SGTC_3077|Compound:9117319|FD-Score:-5.00|P-value:4.68E-9 ID:SGTC_81|Compound:0411-0046|FD-Score:3.21|P-value:1.27E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:2.81|P-value:6.92E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.23|P-value:1.18E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:2.98|P-value:3.43E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.01|P-value:3.05E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:2.82|P-value:6.57E-4 ID:SGTC_223|Compound:busulfan|FD-Score:-3.68|P-value:1.19E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:4.22|P-value:7.14E-7 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.08|P-value:1.98E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.59|P-value:1.86E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.18|P-value:1.46E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.94|P-value:3.52E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:5.13|P-value:2.38E-9 ID:SGTC_762|Compound:1165-0429|FD-Score:3.00|P-value:3.11E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-2.85|P-value:5.21E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.68|P-value:1.34E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.62|P-value:1.62E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:-4.33|P-value:3.37E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.91|P-value:1.03E-8 ID:SGTC_1244|Compound:0416-0015|FD-Score:2.97|P-value:3.58E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.92|P-value:3.93E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:2.96|P-value:3.63E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.65|P-value:1.60E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-2.98|P-value:3.09E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.25|P-value:1.05E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.40|P-value:4.66E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-3.83|P-value:5.50E-6 ID:SGTC_1791|Compound:st048313|FD-Score:-3.02|P-value:2.58E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.39|P-value:4.92E-5 ID:SGTC_1885|Compound:st057546|FD-Score:4.28|P-value:5.21E-7 ID:SGTC_1891|Compound:st059073|FD-Score:4.49|P-value:1.48E-7 ID:SGTC_1904|Compound:st060225|FD-Score:-3.97|P-value:2.60E-6 ID:SGTC_1978|Compound:st071761|FD-Score:-2.72|P-value:8.81E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.77|P-value:7.35E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.74|P-value:8.53E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.98|P-value:3.09E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.58|P-value:2.20E-5 ID:SGTC_2692|Compound:st077426|FD-Score:2.72|P-value:9.72E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.69|P-value:1.27E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-2.86|P-value:5.04E-4 ID:SGTC_2806|Compound:7952793|FD-Score:2.87|P-value:5.47E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.91|P-value:4.07E-6 ID:SGTC_2968|Compound:9090663|FD-Score:-3.73|P-value:9.14E-6 ID:SGTC_2975|Compound:9084847|FD-Score:-4.57|P-value:7.60E-8 ID:SGTC_3005|Compound:9076496|FD-Score:-3.04|P-value:2.39E-4 ID:SGTC_3070|Compound:9117005|FD-Score:-3.80|P-value:6.20E-6 ID:SGTC_3077|Compound:9117319|FD-Score:-5.00|P-value:4.68E-9

Top fitness defect scores for YNL023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_669 0108-0021 5.13 26.2 µM 2.38E-9 fatty acid desaturase (OLE1) 35 1.46E-7
2 SGTC_1239 0337-0584 4.91 35.4 µM 1.03E-8 unfolded protein response 27 4.54E-7
3 SGTC_1891 st059073 4.49 26.2 µM 1.48E-7 TSC3-RPN4 14 3.56E-6
4 SGTC_1885 st057546 4.28 99.9 µM 5.21E-7 14 9.39E-6
5 SGTC_309 k408-0051 4.22 1.5 µM 7.14E-7 39 1.20E-5
6 SGTC_549 1661-1316 3.94 519.0 µM 3.52E-6 20 4.12E-5
7 SGTC_2811 7967822 3.91 32.5 µM 4.07E-6 22 4.61E-5
8 SGTC_2752 diclazuril 3.69 33.1 µM 1.27E-5 138 1.11E-4
9 SGTC_815 1582-0027 3.68 36.9 µM 1.34E-5 39 1.16E-4
10 SGTC_1635 st007035 3.65 42.4 µM 1.60E-5 233 1.33E-4
11 SGTC_2589 lobaric acid 3.58 100.0 µM 2.20E-5 32 1.71E-4
12 SGTC_1687 st020778 3.25 55.4 µM 1.05E-4 215 5.77E-4
13 SGTC_150 3970-0969 3.23 77.2 µM 1.18E-4 103 6.28E-4
14 SGTC_81 0411-0046 3.21 10.0 µM 1.27E-4 40 6.69E-4
15 SGTC_488 nitrendipine 3.18 139.0 µM 1.46E-4 80 7.43E-4
16 SGTC_189 3970-0742 3.01 2.1 µM 3.05E-4 23 0.00132
17 SGTC_762 1165-0429 3.00 115.0 µM 3.11E-4 TSC3-RPN4 63 0.00134
18 SGTC_174 3553-0389 2.98 74.3 µM 3.43E-4 57 0.00145
19 SGTC_1244 0416-0015 2.97 52.5 µM 3.58E-4 ERG2 91 0.00150
20 SGTC_1514 1189-1591 2.96 158.0 µM 3.63E-4 104 0.00151

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 4.33E-23 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.167 1.67E-22 YIL098C FMC1 hom Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
0.163 2.35E-21 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.160 8.59E-21 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.145 3.91E-17 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.143 7.32E-17 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.141 2.36E-16 YIL110W HPM1 hom AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance
0.133 1.17E-14 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.130 4.80E-14 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.130 4.93E-14 YDL023C_d YDL023C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
0.128 8.62E-14 YLR203C MSS51 hom Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis
0.127 1.33E-13 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.124 4.74E-13 YOR008C-A_p YOR008C-A_p hom Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
0.123 7.80E-13 YDR423C CAD1 hom AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication
0.123 1.03E-12 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex