YNL032W / SIW14

Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL032W / SIW14

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.65|P-value:1.20E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.60|P-value:1.45E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:6.01|P-value:8.02E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.81|P-value:6.42E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:3.89|P-value:4.52E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.12|P-value:1.99E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:3.87|P-value:4.97E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:6.89|P-value:2.33E-12 ID:SGTC_129|Compound:0088-0017|FD-Score:7.59|P-value:1.33E-14 ID:SGTC_146|Compound:3448-8650|FD-Score:5.06|P-value:1.84E-7 ID:SGTC_164|Compound:4100-3994|FD-Score:5.24|P-value:7.19E-8 ID:SGTC_196|Compound:k015-0023|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.31|P-value:1.13E-13 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.70|P-value:1.13E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.13|P-value:9.13E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-5.08|P-value:2.03E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:3.18|P-value:6.77E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.80|P-value:6.59E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:3.30|P-value:4.54E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.20|P-value:6.42E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.08|P-value:9.59E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.10|P-value:9.11E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.27|P-value:4.96E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.97|P-value:2.98E-7 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.25|P-value:5.33E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.44|P-value:3.10E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.45|P-value:3.87E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:7.28|P-value:1.43E-13 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.23|P-value:7.70E-8 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.16|P-value:1.48E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.10|P-value:1.93E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.08|P-value:9.72E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.11|P-value:9.86E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-3.22|P-value:6.69E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.05|P-value:2.34E-5 ID:SGTC_1731|Compound:st035964|FD-Score:5.62|P-value:8.30E-9 ID:SGTC_1745|Compound:st081495|FD-Score:-3.34|P-value:4.47E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-4.60|P-value:2.31E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.49|P-value:2.28E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.24|P-value:6.19E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.95|P-value:3.64E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.24|P-value:1.87E-13 ID:SGTC_1884|Compound:5633444|FD-Score:3.12|P-value:8.58E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.81|P-value:6.48E-5 ID:SGTC_2092|Compound:5303694|FD-Score:-3.20|P-value:7.32E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.98|P-value:3.13E-5 ID:SGTC_2142|Compound:5622915|FD-Score:3.87|P-value:5.01E-5 ID:SGTC_2237|Compound:6667747|FD-Score:3.86|P-value:5.13E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-3.13|P-value:9.16E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.09|P-value:1.99E-5 ID:SGTC_2511|Compound:berberine|FD-Score:-3.43|P-value:3.25E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.83|P-value:6.84E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:5.14|P-value:1.24E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.13|P-value:8.07E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.63|P-value:1.33E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.33|P-value:4.44E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:4.42|P-value:4.39E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.94|P-value:3.81E-5 ID:SGTC_2646|Compound:retinol|FD-Score:3.46|P-value:2.51E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.55|P-value:2.38E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.48|P-value:1.93E-8 ID:SGTC_2867|Compound:9039098|FD-Score:-4.11|P-value:2.07E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.78|P-value:7.22E-5 ID:SGTC_2958|Compound:9077254|FD-Score:3.28|P-value:4.84E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.64|P-value:1.54E-6 ID:SGTC_3141|Compound:9094609|FD-Score:-3.15|P-value:8.63E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.26|P-value:5.16E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.37|P-value:3.98E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.65|P-value:1.20E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.60|P-value:1.45E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:6.01|P-value:8.02E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.81|P-value:6.42E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:3.89|P-value:4.52E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.12|P-value:1.99E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:3.87|P-value:4.97E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:6.89|P-value:2.33E-12 ID:SGTC_129|Compound:0088-0017|FD-Score:7.59|P-value:1.33E-14 ID:SGTC_146|Compound:3448-8650|FD-Score:5.06|P-value:1.84E-7 ID:SGTC_164|Compound:4100-3994|FD-Score:5.24|P-value:7.19E-8 ID:SGTC_196|Compound:k015-0023|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.31|P-value:1.13E-13 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.70|P-value:1.13E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.13|P-value:9.13E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-5.08|P-value:2.03E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:3.18|P-value:6.77E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.80|P-value:6.59E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:3.30|P-value:4.54E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.20|P-value:6.42E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.08|P-value:9.59E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.10|P-value:9.11E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.27|P-value:4.96E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.97|P-value:2.98E-7 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.25|P-value:5.33E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.44|P-value:3.10E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.45|P-value:3.87E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:7.28|P-value:1.43E-13 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.23|P-value:7.70E-8 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.16|P-value:1.48E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.10|P-value:1.93E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.08|P-value:9.72E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.11|P-value:9.86E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-3.22|P-value:6.69E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.05|P-value:2.34E-5 ID:SGTC_1731|Compound:st035964|FD-Score:5.62|P-value:8.30E-9 ID:SGTC_1745|Compound:st081495|FD-Score:-3.34|P-value:4.47E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-4.60|P-value:2.31E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.49|P-value:2.28E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.24|P-value:6.19E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.95|P-value:3.64E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.24|P-value:1.87E-13 ID:SGTC_1884|Compound:5633444|FD-Score:3.12|P-value:8.58E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.81|P-value:6.48E-5 ID:SGTC_2092|Compound:5303694|FD-Score:-3.20|P-value:7.32E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.98|P-value:3.13E-5 ID:SGTC_2142|Compound:5622915|FD-Score:3.87|P-value:5.01E-5 ID:SGTC_2237|Compound:6667747|FD-Score:3.86|P-value:5.13E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-3.13|P-value:9.16E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.09|P-value:1.99E-5 ID:SGTC_2511|Compound:berberine|FD-Score:-3.43|P-value:3.25E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.83|P-value:6.84E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:5.14|P-value:1.24E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.13|P-value:8.07E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.63|P-value:1.33E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.33|P-value:4.44E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:4.42|P-value:4.39E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.94|P-value:3.81E-5 ID:SGTC_2646|Compound:retinol|FD-Score:3.46|P-value:2.51E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.55|P-value:2.38E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.48|P-value:1.93E-8 ID:SGTC_2867|Compound:9039098|FD-Score:-4.11|P-value:2.07E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.78|P-value:7.22E-5 ID:SGTC_2958|Compound:9077254|FD-Score:3.28|P-value:4.84E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.64|P-value:1.54E-6 ID:SGTC_3141|Compound:9094609|FD-Score:-3.15|P-value:8.63E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.26|P-value:5.16E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.37|P-value:3.98E-4

Top fitness defect scores for YNL032W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_129 0088-0017 7.59 176.6 µM 1.33E-14 19 1.60E-14
2 SGTC_221 trifluoperazine 7.31 10.3 µM 1.13E-13 NEO1-PIK1 97 1.34E-13
3 SGTC_1226 3909-7979 7.28 35.4 µM 1.43E-13 11 1.70E-13
4 SGTC_1877 wortmannin 7.24 25.0 µM 1.87E-13 30 2.21E-13
5 SGTC_87 0100-0052 6.89 35.5 µM 2.33E-12 20 2.73E-12
6 SGTC_18 0111-0177 6.01 500.0 nM 8.02E-10 18 9.19E-10
7 SGTC_1731 st035964 5.62 63.0 µM 8.30E-9 7 9.41E-9
8 SGTC_2688 kanamycin b 5.48 96.7 µM 1.93E-8 calcium & mitochondrial duress 196 2.18E-8
9 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 5.33 70.0 µM 4.44E-8 redox potentiating 35 5.00E-8
10 SGTC_164 4100-3994 5.24 89.6 µM 7.19E-8 11 8.08E-8
11 SGTC_1304 1165-0502 5.23 251.0 µM 7.70E-8 42 8.65E-8
12 SGTC_2524 avocatin b 5.14 10.6 µM 1.24E-7 13 1.39E-7
13 SGTC_146 3448-8650 5.06 53.1 µM 1.84E-7 NEO1-PIK1 85 2.06E-7
14 SGTC_1035 k081-0041 4.97 55.2 µM 2.98E-7 Golgi 12 3.33E-7
15 SGTC_3020 9089140 4.64 49.5 µM 1.54E-6 14 1.71E-6
16 SGTC_2651 1327-0036 4.55 5.0 µM 2.38E-6 134 2.63E-6
17 SGTC_1178 0988-0033 4.45 191.0 µM 3.87E-6 20 4.26E-6
18 SGTC_2619 obliquin 4.42 87.9 µM 4.39E-6 cell wall 123 4.83E-6
19 SGTC_1308 1187-1617 4.16 41.4 µM 1.48E-5 fatty acid desaturase (OLE1) 33 1.62E-5
20 SGTC_1355 1499-0035 4.10 1.7 µM 1.93E-5 15 2.10E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.369 1.50E-108 YCR095C_p OCA4_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.299 3.88E-70 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.269 6.66E-57 YHL029C_p OCA5_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.261 1.81E-53 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.244 1.37E-46 YDR067C_p OCA6_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT
0.209 1.79E-34 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.200 9.99E-32 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.200 1.90E-31 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.188 6.15E-28 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.179 1.57E-25 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.176 8.78E-25 YHL011C PRS3 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
0.175 2.24E-24 YDR156W RPA14 hom RNA polymerase I subunit A14
0.173 4.82E-24 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.170 3.52E-23 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.169 6.76E-23 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol