HIPHOP chemogenomics database

YNL043C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL043C / YNL043C

Click on Significant Values for Screen Details

Top fitness defect scores for YNL043C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2792	7535235	13.70	81.8 µM	2.52E-42	fatty acid desaturase (OLE1)	1	4.22E-43
2	SGTC_1528	arabinosylhypoxanthine	7.92	74.6 µM	2.17E-15		2	1.15E-15
3	SGTC_2688	kanamycin b	6.77	96.7 µM	9.97E-12	calcium & mitochondrial duress	114	6.22E-12
4	SGTC_1789	tunicamycin	5.31	25.0 nM	7.59E-8	unfolded protein response	26	5.61E-8
5	SGTC_735	3076-0345	4.93	636.0 µM	5.27E-7		12	4.04E-7
6	SGTC_1645	Cervolide	4.92	78.0 µM	5.56E-7		1	4.27E-7
7	SGTC_2686	alizarin	4.78	95.4 µM	1.12E-6	RPP1 & pyrimidine depletion	17	8.68E-7
8	SGTC_750	4073-0104	4.44	132.0 µM	5.72E-6		6	4.59E-6
9	SGTC_2799	7812892	4.29	81.8 µM	1.11E-5	superoxide	24	8.99E-6
10	SGTC_353	1988-1175	4.06	58.3 µM	2.91E-5	unfolded protein response	24	2.41E-5
11	SGTC_2445	5742597	3.96	35.6 µM	4.55E-5		37	3.80E-5
12	SGTC_3191	9110352	3.84	49.5 µM	7.20E-5		12	6.06E-5
13	SGTC_245	methotrexate	3.75	289.6 µM	1.06E-4		50	8.95E-5
14	SGTC_1605	st000082	3.74	49.1 µM	1.07E-4	60S ribosome export	21	9.04E-5
15	SGTC_473	2-arachidonoylglycerol	3.68	10.0 µM	1.36E-4		23	1.16E-4
16	SGTC_1597	7-benzyloxygramine	3.64	47.5 µM	1.58E-4	calcium & mitochondrial duress	143	1.35E-4
17	SGTC_3037	9091026	3.55	49.5 µM	2.21E-4	NEO1-PIK1	147	1.90E-4
18	SGTC_1137	ixabepilone	3.53	100.0 µM	2.45E-4		44	2.11E-4
19	SGTC_868	0527-0199	3.49	213.0 µM	2.79E-4	fatty acid desaturase (OLE1)	42	2.41E-4
20	SGTC_1125	tnp00248	3.38	1.3 µM	4.09E-4		62	3.56E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.168	9.82E-23	YDR101C	ARX1	hom	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.162	3.41E-21	YNL219C	ALG9	hom	Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.156	1.16E-19	YHR164C	DNA2	het	Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.139	5.16E-16	YGR259C_d	YGR259C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
0.138	9.91E-16	YGR206W	MVB12	hom	ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.134	6.24E-15	YDR467C_d	YDR467C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.134	7.25E-15	YKL091C	YKL091C	hom	Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study
0.131	2.73E-14	YMR099C	YMR099C	hom	Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.131	3.16E-14	YML019W	OST6	hom	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
0.129	6.38E-14	YMR142C	RPL13B	hom	Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication
0.128	9.19E-14	YDR248C_p	YDR248C_p	hom	Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1
0.123	7.98E-13	YOL031C	SIL1	hom	Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
0.122	1.40E-12	YGL079W_p	KXD1_p	hom	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.121	2.03E-12	YGL078C	DBP3	hom	RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype
0.119	5.13E-12	YBL082C	ALG3	hom	Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins