YNL049C / SFB2

Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL049C / SFB2

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.49|P-value:1.02E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.29|P-value:2.55E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:3.04|P-value:6.21E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:2.91|P-value:9.68E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.72|P-value:3.88E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.19|P-value:3.50E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:5.53|P-value:2.11E-9 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.95|P-value:1.40E-5 ID:SGTC_446|Compound:go6976|FD-Score:2.96|P-value:8.21E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.02|P-value:6.71E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:5.31|P-value:8.14E-9 ID:SGTC_711|Compound:k292-0785|FD-Score:3.42|P-value:1.37E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.43|P-value:1.32E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.56|P-value:7.73E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:2.93|P-value:9.30E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.94|P-value:7.52E-8 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.08|P-value:5.59E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.39|P-value:1.59E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.12|P-value:4.52E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.44|P-value:1.36E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.69|P-value:4.40E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.36|P-value:1.88E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.26|P-value:2.70E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:2.93|P-value:9.13E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.13|P-value:5.62E-6 ID:SGTC_1661|Compound:st013063|FD-Score:4.62|P-value:4.58E-7 ID:SGTC_1757|Compound:st041620|FD-Score:3.43|P-value:1.31E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.19|P-value:3.52E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-3.84|P-value:2.38E-5 ID:SGTC_2053|Compound:5265679|FD-Score:4.05|P-value:8.49E-6 ID:SGTC_2188|Compound:6126565|FD-Score:-3.02|P-value:6.96E-4 ID:SGTC_2292|Compound:7671323|FD-Score:4.06|P-value:8.07E-6 ID:SGTC_2386|Compound:9075165|FD-Score:-3.42|P-value:1.47E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.34|P-value:1.93E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.43|P-value:1.38E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.45|P-value:1.21E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.73|P-value:3.59E-5 ID:SGTC_2625|Compound:euphol|FD-Score:2.94|P-value:8.78E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.57|P-value:7.24E-5 ID:SGTC_2717|Compound:st081029|FD-Score:3.79|P-value:2.81E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.85|P-value:2.29E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.48|P-value:1.15E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.92|P-value:1.53E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.05|P-value:5.80E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.12|P-value:4.45E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.49|P-value:1.02E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.29|P-value:2.55E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:3.04|P-value:6.21E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:2.91|P-value:9.68E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.72|P-value:3.88E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.19|P-value:3.50E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:5.53|P-value:2.11E-9 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.95|P-value:1.40E-5 ID:SGTC_446|Compound:go6976|FD-Score:2.96|P-value:8.21E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.02|P-value:6.71E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:5.31|P-value:8.14E-9 ID:SGTC_711|Compound:k292-0785|FD-Score:3.42|P-value:1.37E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.43|P-value:1.32E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.56|P-value:7.73E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:2.93|P-value:9.30E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.94|P-value:7.52E-8 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.08|P-value:5.59E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.39|P-value:1.59E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.12|P-value:4.52E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.44|P-value:1.36E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.69|P-value:4.40E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.36|P-value:1.88E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.26|P-value:2.70E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:2.93|P-value:9.13E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.13|P-value:5.62E-6 ID:SGTC_1661|Compound:st013063|FD-Score:4.62|P-value:4.58E-7 ID:SGTC_1757|Compound:st041620|FD-Score:3.43|P-value:1.31E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.19|P-value:3.52E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-3.84|P-value:2.38E-5 ID:SGTC_2053|Compound:5265679|FD-Score:4.05|P-value:8.49E-6 ID:SGTC_2188|Compound:6126565|FD-Score:-3.02|P-value:6.96E-4 ID:SGTC_2292|Compound:7671323|FD-Score:4.06|P-value:8.07E-6 ID:SGTC_2386|Compound:9075165|FD-Score:-3.42|P-value:1.47E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.34|P-value:1.93E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.43|P-value:1.38E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.45|P-value:1.21E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.73|P-value:3.59E-5 ID:SGTC_2625|Compound:euphol|FD-Score:2.94|P-value:8.78E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.57|P-value:7.24E-5 ID:SGTC_2717|Compound:st081029|FD-Score:3.79|P-value:2.81E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.85|P-value:2.29E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.48|P-value:1.15E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.92|P-value:1.53E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.05|P-value:5.80E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.12|P-value:4.45E-4

Top fitness defect scores for YNL049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_343 4130-2827 5.53 29.8 µM 2.11E-9 8 1.61E-8
2 SGTC_662 k832-1615 5.31 104.0 µM 8.14E-9 4 5.36E-8
3 SGTC_1048 3161-0300 4.94 24.5 µM 7.52E-8 10 3.87E-7
4 SGTC_1661 st013063 4.62 9.7 µM 4.58E-7 16 1.93E-6
5 SGTC_127 0180-0333 4.29 59.1 µM 2.55E-6 mitochondrial response to ROS 30 8.91E-6
6 SGTC_1448 4255-0083 4.13 152.0 µM 5.62E-6 ERG2 14 1.80E-5
7 SGTC_2292 7671323 4.06 168.1 µM 8.07E-6 RNA processing & uracil transport 29 2.49E-5
8 SGTC_2053 5265679 4.05 138.0 µM 8.49E-6 22 2.60E-5
9 SGTC_2834 9001755 3.92 58.4 µM 1.53E-5 36 4.40E-5
10 SGTC_2717 st081029 3.79 62.3 µM 2.81E-5 21 7.57E-5
11 SGTC_2562 3',7'-dimethoxyflavone 3.73 64.9 µM 3.59E-5 37 9.40E-5
12 SGTC_265 mycophenolic acid 3.72 32.9 µM 3.88E-5 RPP1 & pyrimidine depletion 26 1.01E-4
13 SGTC_1249 0481-0015 3.69 10.2 µM 4.40E-5 31 1.13E-4
14 SGTC_2716 st080858 3.57 38.6 µM 7.24E-5 60S ribosome export 26 1.76E-4
15 SGTC_913 3487-1245 3.56 167.0 µM 7.73E-5 47 1.87E-4
16 SGTC_8 0354-0001 3.49 70.0 µM 1.02E-4 101 2.38E-4
17 SGTC_2486 5283202 3.45 22.4 µM 1.21E-4 56 2.77E-4
18 SGTC_1757 st041620 3.43 31.8 µM 1.31E-4 43 2.98E-4
19 SGTC_780 0109-0199 3.43 192.0 µM 1.32E-4 37 3.01E-4
20 SGTC_711 k292-0785 3.42 179.0 µM 1.37E-4 DNA intercalators 39 3.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.74E-11 YGL141W HUL5 hom Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
0.111 1.08E-10 YNL104C LEU4 hom Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
0.096 3.03E-8 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.092 9.05E-8 YPR021C AGC1 hom Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis
0.089 2.31E-7 YMR140W SIP5 hom Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress
0.086 5.74E-7 YNL254C RTC4 hom Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.079 5.12E-6 YOL039W RPP2A hom Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.079 5.23E-6 YDR250C_d YDR250C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.079 5.33E-6 YAL064C-A_p TDA8_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene
0.077 7.75E-6 YJR051W OSM1 hom Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication
0.076 1.05E-5 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.076 1.09E-5 YLR231C BNA5 hom Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.075 1.41E-5 YJL217W REE1 hom Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle
0.074 1.98E-5 YNL216W RAP1 het Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)
0.072 2.83E-5 YBR241C_p YBR241C_p hom Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene