YNL072W / RNH201

Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL072W / RNH201

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.80|P-value:6.37E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:4.15|P-value:1.93E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.39|P-value:1.65E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.90|P-value:4.54E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.90|P-value:4.65E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-2.95|P-value:7.53E-4 ID:SGTC_512|Compound:prima-1|FD-Score:-3.15|P-value:3.80E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.30|P-value:2.25E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.15|P-value:1.90E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.07|P-value:2.57E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:-2.90|P-value:8.87E-4 ID:SGTC_1530|Compound:rhein|FD-Score:4.06|P-value:2.70E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.19|P-value:1.69E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.69|P-value:2.40E-5 ID:SGTC_1554|Compound:st069299|FD-Score:4.85|P-value:1.26E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:4.02|P-value:3.02E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.47|P-value:5.83E-5 ID:SGTC_1594|Compound:piperine|FD-Score:3.74|P-value:7.92E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.89|P-value:4.74E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.18|P-value:1.73E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-4.84|P-value:3.51E-7 ID:SGTC_1636|Compound:st007707|FD-Score:-2.96|P-value:7.14E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.79|P-value:3.66E-5 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:4.09|P-value:2.42E-4 ID:SGTC_1774|Compound:st048371|FD-Score:4.33|P-value:9.82E-5 ID:SGTC_1781|Compound:st038725|FD-Score:3.89|P-value:4.70E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.99|P-value:3.44E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.00|P-value:6.26E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:-2.88|P-value:9.39E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.22|P-value:2.99E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-2.86|P-value:9.96E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.08|P-value:1.08E-5 ID:SGTC_2033|Compound:5192550|FD-Score:4.48|P-value:5.56E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.40|P-value:7.53E-5 ID:SGTC_2168|Compound:5727979|FD-Score:3.67|P-value:9.89E-4 ID:SGTC_2260|Compound:7964312|FD-Score:4.41|P-value:7.47E-5 ID:SGTC_2416|Compound:tofa|FD-Score:-3.20|P-value:3.19E-4 ID:SGTC_2432|Compound:5630864|FD-Score:4.34|P-value:9.64E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.95|P-value:3.89E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.02|P-value:3.02E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.12|P-value:2.16E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.67|P-value:9.69E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.74|P-value:7.76E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.85|P-value:5.46E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.55|P-value:4.20E-5 ID:SGTC_3133|Compound:9127736|FD-Score:-2.90|P-value:8.69E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-3.32|P-value:2.15E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.11|P-value:4.45E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.80|P-value:6.37E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:4.15|P-value:1.93E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.39|P-value:1.65E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.90|P-value:4.54E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.90|P-value:4.65E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-2.95|P-value:7.53E-4 ID:SGTC_512|Compound:prima-1|FD-Score:-3.15|P-value:3.80E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.30|P-value:2.25E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.15|P-value:1.90E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.07|P-value:2.57E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:-2.90|P-value:8.87E-4 ID:SGTC_1530|Compound:rhein|FD-Score:4.06|P-value:2.70E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.19|P-value:1.69E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.69|P-value:2.40E-5 ID:SGTC_1554|Compound:st069299|FD-Score:4.85|P-value:1.26E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:4.02|P-value:3.02E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.47|P-value:5.83E-5 ID:SGTC_1594|Compound:piperine|FD-Score:3.74|P-value:7.92E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.89|P-value:4.74E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.18|P-value:1.73E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-4.84|P-value:3.51E-7 ID:SGTC_1636|Compound:st007707|FD-Score:-2.96|P-value:7.14E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.79|P-value:3.66E-5 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:4.09|P-value:2.42E-4 ID:SGTC_1774|Compound:st048371|FD-Score:4.33|P-value:9.82E-5 ID:SGTC_1781|Compound:st038725|FD-Score:3.89|P-value:4.70E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.99|P-value:3.44E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.00|P-value:6.26E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:-2.88|P-value:9.39E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.22|P-value:2.99E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-2.86|P-value:9.96E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.08|P-value:1.08E-5 ID:SGTC_2033|Compound:5192550|FD-Score:4.48|P-value:5.56E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.40|P-value:7.53E-5 ID:SGTC_2168|Compound:5727979|FD-Score:3.67|P-value:9.89E-4 ID:SGTC_2260|Compound:7964312|FD-Score:4.41|P-value:7.47E-5 ID:SGTC_2416|Compound:tofa|FD-Score:-3.20|P-value:3.19E-4 ID:SGTC_2432|Compound:5630864|FD-Score:4.34|P-value:9.64E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.95|P-value:3.89E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.02|P-value:3.02E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.12|P-value:2.16E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.67|P-value:9.69E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.74|P-value:7.76E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.85|P-value:5.46E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.55|P-value:4.20E-5 ID:SGTC_3133|Compound:9127736|FD-Score:-2.90|P-value:8.69E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-3.32|P-value:2.15E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.11|P-value:4.45E-4

Top fitness defect scores for YNL072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1554 st069299 4.85 38.7 µM 1.26E-5 7 6.15E-7
2 SGTC_1551 6-bromo-3'-methylflavone 4.69 63.5 µM 2.40E-5 5 1.34E-6
3 SGTC_3131 9127911 4.55 49.5 µM 4.20E-5 16 2.63E-6
4 SGTC_2033 5192550 4.48 145.0 µM 5.56E-5 6 3.68E-6
5 SGTC_1580 hydrocortisone 21-hemisuccinate 4.47 43.2 µM 5.83E-5 11 3.90E-6
6 SGTC_2260 7964312 4.41 200.0 µM 7.47E-5 6 5.27E-6
7 SGTC_2042 p-Dimethylaminoacetophenone 4.40 200.0 µM 7.53E-5 11 5.32E-6
8 SGTC_2432 5630864 4.34 12.2 µM 9.64E-5 15 7.17E-6
9 SGTC_1774 st048371 4.33 48.5 µM 9.82E-5 RNA processing & uracil transport 10 7.33E-6
10 SGTC_1550 gossypolone 4.19 36.6 µM 1.69E-4 10 1.41E-5
11 SGTC_1599 8-chlro-1-tetrahydronorharmanone 4.18 90.6 µM 1.73E-4 29 1.46E-5
12 SGTC_1014 4130-3005 4.15 69.3 µM 1.90E-4 13 1.63E-5
13 SGTC_49 0717-0965 4.15 32.1 µM 1.93E-4 60S ribosome export 17 1.66E-5
14 SGTC_2453 5731132 4.12 22.2 µM 2.16E-4 17 1.91E-5
15 SGTC_1692 fluoroquinolonic acid 4.09 71.0 µM 2.42E-4 4 2.19E-5
16 SGTC_1075 aripiprazole 4.07 15.2 µM 2.57E-4 25 2.36E-5
17 SGTC_1530 rhein 4.06 70.4 µM 2.70E-4 16 2.51E-5
18 SGTC_1578 josamycin 4.02 24.2 µM 3.02E-4 12 2.87E-5
19 SGTC_2451 5856223 4.02 45.7 µM 3.02E-4 22 2.87E-5
20 SGTC_1841 st054148 3.99 70.0 µM 3.44E-4 10 3.36E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.082 1.92E-6 YHR124W NDT80 hom Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
0.081 2.94E-6 YOR041C_d YOR041C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance
0.075 1.35E-5 YKL026C GPX1 hom Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
0.070 5.47E-5 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.065 1.50E-4 YPL081W RPS9A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication
0.065 1.55E-4 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.064 2.06E-4 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.063 2.77E-4 YML112W CTK3 hom Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress
0.062 3.07E-4 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.062 3.47E-4 YDR484W VPS52 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin
0.061 4.21E-4 YKL174C TPO5 hom Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
0.061 4.27E-4 YGL071W AFT1 hom Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.060 4.66E-4 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.059 5.92E-4 YCL002C_p YCL002C_p hom Putative protein of unknown function; YCL002C is not an essential gene
0.059 6.52E-4 YOR335C ALA1 het Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog