YNL080C / EOS1

Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL080C / EOS1

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:-3.81|P-value:1.46E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:5.04|P-value:1.03E-6 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.82|P-value:1.46E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.95|P-value:8.86E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.39|P-value:7.15E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.46|P-value:5.67E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.38|P-value:6.51E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.75|P-value:1.84E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-9.11|P-value:3.07E-18 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.29|P-value:9.94E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:-3.79|P-value:1.57E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:-4.77|P-value:3.08E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.40|P-value:6.29E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:-7.02|P-value:1.44E-11 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.33|P-value:7.73E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.37|P-value:6.91E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-4.24|P-value:2.85E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.15|P-value:4.72E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.87|P-value:1.39E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.63|P-value:2.80E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.54|P-value:4.40E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.49|P-value:5.24E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.76|P-value:2.04E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.85|P-value:1.27E-4 ID:SGTC_1662|Compound:st014054|FD-Score:3.45|P-value:5.93E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.31|P-value:2.53E-5 ID:SGTC_1776|Compound:st049249|FD-Score:4.25|P-value:3.22E-5 ID:SGTC_1780|Compound:st038448|FD-Score:4.21|P-value:3.73E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.49|P-value:4.52E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-3.30|P-value:8.52E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.32|P-value:8.02E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-4.23|P-value:2.93E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.38|P-value:7.36E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-3.35|P-value:7.24E-4 ID:SGTC_2200|Compound:6600604|FD-Score:-3.34|P-value:7.50E-4 ID:SGTC_2202|Compound:7226349|FD-Score:4.42|P-value:1.57E-5 ID:SGTC_2293|Compound:7624732|FD-Score:3.62|P-value:3.38E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.42|P-value:6.54E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-6.36|P-value:8.42E-10 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-4.12|P-value:4.62E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.53|P-value:8.60E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.12|P-value:5.35E-5 ID:SGTC_2864|Compound:9034755|FD-Score:3.96|P-value:9.94E-5 ID:SGTC_2868|Compound:9035608|FD-Score:4.10|P-value:5.72E-5 ID:SGTC_2908|Compound:7930301|FD-Score:-4.27|P-value:2.55E-5 ID:SGTC_2983|Compound:9022671|FD-Score:-5.16|P-value:5.03E-7 ID:SGTC_3117|Compound:9124945|FD-Score:-3.65|P-value:2.64E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-5.31|P-value:2.33E-7 ID:SGTC_3140|Compound:9094243|FD-Score:3.53|P-value:4.58E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.54|P-value:3.82E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.17|P-value:3.79E-5 ID:SGTC_3349|Compound:9149703|FD-Score:3.94|P-value:1.05E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.95|P-value:1.01E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.81|P-value:1.46E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:5.04|P-value:1.03E-6 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.82|P-value:1.46E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.95|P-value:8.86E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.39|P-value:7.15E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.46|P-value:5.67E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.38|P-value:6.51E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.75|P-value:1.84E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-9.11|P-value:3.07E-18 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.29|P-value:9.94E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:-3.79|P-value:1.57E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:-4.77|P-value:3.08E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.40|P-value:6.29E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:-7.02|P-value:1.44E-11 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.33|P-value:7.73E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.37|P-value:6.91E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-4.24|P-value:2.85E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.15|P-value:4.72E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.87|P-value:1.39E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.63|P-value:2.80E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.54|P-value:4.40E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.49|P-value:5.24E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.76|P-value:2.04E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.85|P-value:1.27E-4 ID:SGTC_1662|Compound:st014054|FD-Score:3.45|P-value:5.93E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.31|P-value:2.53E-5 ID:SGTC_1776|Compound:st049249|FD-Score:4.25|P-value:3.22E-5 ID:SGTC_1780|Compound:st038448|FD-Score:4.21|P-value:3.73E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.49|P-value:4.52E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-3.30|P-value:8.52E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.32|P-value:8.02E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-4.23|P-value:2.93E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.38|P-value:7.36E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-3.35|P-value:7.24E-4 ID:SGTC_2200|Compound:6600604|FD-Score:-3.34|P-value:7.50E-4 ID:SGTC_2202|Compound:7226349|FD-Score:4.42|P-value:1.57E-5 ID:SGTC_2293|Compound:7624732|FD-Score:3.62|P-value:3.38E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.42|P-value:6.54E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-6.36|P-value:8.42E-10 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-4.12|P-value:4.62E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.53|P-value:8.60E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.12|P-value:5.35E-5 ID:SGTC_2864|Compound:9034755|FD-Score:3.96|P-value:9.94E-5 ID:SGTC_2868|Compound:9035608|FD-Score:4.10|P-value:5.72E-5 ID:SGTC_2908|Compound:7930301|FD-Score:-4.27|P-value:2.55E-5 ID:SGTC_2983|Compound:9022671|FD-Score:-5.16|P-value:5.03E-7 ID:SGTC_3117|Compound:9124945|FD-Score:-3.65|P-value:2.64E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-5.31|P-value:2.33E-7 ID:SGTC_3140|Compound:9094243|FD-Score:3.53|P-value:4.58E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.54|P-value:3.82E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.17|P-value:3.79E-5 ID:SGTC_3349|Compound:9149703|FD-Score:3.94|P-value:1.05E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.95|P-value:1.01E-4

Top fitness defect scores for YNL080C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_69 0096-0274 5.04 206.7 µM 1.03E-6 mitochondrial processes 18 2.30E-7
2 SGTC_2202 7226349 4.42 200.0 µM 1.57E-5 2 4.83E-6
3 SGTC_1755 st041960 4.31 45.2 µM 2.53E-5 16 8.25E-6
4 SGTC_1776 st049249 4.25 45.9 µM 3.22E-5 12 1.08E-5
5 SGTC_1780 st038448 4.21 24.5 µM 3.73E-5 iron homeostasis 10 1.27E-5
6 SGTC_1247 0448-0043 4.15 5.8 µM 4.72E-5 ERG2 34 1.66E-5
7 SGTC_2759 disulfiram 4.12 3.4 µM 5.35E-5 22 1.90E-5
8 SGTC_2868 9035608 4.10 32.5 µM 5.72E-5 15 2.05E-5
9 SGTC_2864 9034755 3.96 47.6 µM 9.94E-5 8 3.81E-5
10 SGTC_3353 9151644 3.95 39.3 µM 1.01E-4 12 3.86E-5
11 SGTC_3349 9149703 3.94 23.0 µM 1.05E-4 13 4.05E-5
12 SGTC_1248 0469-0687 3.87 58.6 µM 1.39E-4 31 5.54E-5
13 SGTC_1638 st008370 3.76 60.6 µM 2.04E-4 ergosterol biosynthesis 35 8.52E-5
14 SGTC_2293 7624732 3.62 200.0 µM 3.38E-4 36 1.49E-4
15 SGTC_1604 st002052 3.54 72.4 µM 4.40E-4 TSC3-RPN4 35 2.01E-4
16 SGTC_3140 9094243 3.53 49.5 µM 4.58E-4 40 2.10E-4
17 SGTC_1616 st002734 3.49 56.1 µM 5.24E-4 48 2.44E-4
18 SGTC_747 3448-8087 3.46 38.7 µM 5.67E-4 41 2.66E-4
19 SGTC_1662 st014054 3.45 52.0 µM 5.93E-4 TSC3-RPN4 8 2.80E-4
20 SGTC_2331 7980721 3.42 200.0 µM 6.54E-4 41 3.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 5.09E-9 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.088 3.05E-7 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.085 8.47E-7 YBL045C COR1 hom Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
0.077 7.59E-6 YPL223C GRE1 hom Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
0.076 1.11E-5 YBR289W SNF5 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions
0.075 1.26E-5 YBR196C-A_p YBR196C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.075 1.31E-5 YIL017C VID28 hom GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
0.075 1.31E-5 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.075 1.43E-5 YIR033W MGA2 hom ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
0.074 1.73E-5 YLR226W BUR2 hom Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II
0.074 1.96E-5 YGR115C_d YGR115C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C
0.073 2.07E-5 YDR153C ENT5 hom Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
0.073 2.14E-5 YJL034W KAR2 het ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
0.071 4.27E-5 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.070 5.08E-5 YLR174W IDP2 hom Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication