HIPHOP chemogenomics database

YNL105W_d / RRT16

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL105W / RRT16

Click on Significant Values for Screen Details

Top fitness defect scores for YNL105W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2582	agaric acid	12.90	100.0 µM	5.60E-51	redox potentiating	31	3.32E-38
2	SGTC_67	0335-0847	10.60	266.0 µM	1.56E-35	ubiquinone biosynthesis & proteasome	18	8.96E-27
3	SGTC_3210	9128157	8.31	49.5 µM	2.00E-22		5	4.59E-17
4	SGTC_64	000l-0018	6.78	272.1 µM	1.62E-15	ubiquinone biosynthesis & proteasome	63	6.15E-12
5	SGTC_65	0798-0905	6.27	35.0 µM	1.51E-13	calcium & mitochondrial duress	26	1.79E-10
6	SGTC_1714	st033236	4.91	13.6 µM	5.67E-9		9	4.55E-7
7	SGTC_2584	androsterone	4.90	48.7 µM	6.08E-9	cell wall	84	4.79E-7
8	SGTC_1595	6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin	4.47	67.5 µM	9.91E-8		24	3.85E-6
9	SGTC_2009	4012297	4.23	12.1 µM	4.47E-7	cell wall signaling	54	1.19E-5
10	SGTC_2912	7964298	3.98	10.9 µM	1.90E-6	cell wall	96	3.50E-5
11	SGTC_634	1611-4317	3.57	11.2 µM	1.64E-5	ERG2	29	1.77E-4
12	SGTC_1142	3253-1408	3.55	9.8 µM	1.85E-5		21	1.93E-4
13	SGTC_2633	5,7-dihydroxyisoflavone	3.47	100.0 µM	2.69E-5		45	2.56E-4
14	SGTC_2454	5-benzylidenerhodanine	3.44	10.4 µM	3.25E-5	TRP & mitochondrial translation	65	2.95E-4
15	SGTC_2926	9010726	3.27	65.2 µM	7.07E-5		53	5.29E-4
16	SGTC_138	0850-0259	3.13	40.9 µM	1.36E-4	cell wall	265	8.67E-4
17	SGTC_360	0957-0399	3.12	1.0 µM	1.43E-4	cell wall	90	8.99E-4
18	SGTC_2631	bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone	2.95	100.0 µM	3.10E-4		80	0.00161
19	SGTC_2566	crystal violet carbinol	2.94	226.0 nM	3.20E-4		91	0.00165
20	SGTC_2262	9014885	2.84	67.5 µM	4.78E-4		20	0.00224

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.422	1.59E-144	YNL106C	INP52	hom	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.313	3.59E-77	YMR110C	HFD1	hom	Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.312	1.37E-76	YJR091C	JSN1	hom	Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.297	3.25E-69	YLR199C	PBA1	hom	Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.286	2.32E-64	YNL027W	CRZ1	hom	Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.278	1.36E-60	YML103C	NUP188	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.270	2.91E-57	YJL168C	SET2	hom	Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.269	9.46E-57	YPL232W	SSO1	hom	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.264	9.95E-55	YML052W	SUR7	hom	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.264	1.18E-54	YEL007W	MIT1	hom	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.262	7.23E-54	YDL194W	SNF3	hom	Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication
0.257	1.01E-51	YJL155C	FBP26	hom	Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.256	3.40E-51	YPR146C_d	YPR146C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.247	6.76E-48	YLR331C_d	JIP3_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.244	1.15E-46	YPR024W	YME1	hom	Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover