YNL122C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL122C / YNL122C

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:4.45|P-value:2.50E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:3.23|P-value:4.49E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:5.25|P-value:3.44E-8 ID:SGTC_166|Compound:k072-0058|FD-Score:5.00|P-value:1.43E-7 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.21|P-value:4.86E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.17|P-value:5.71E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.53|P-value:1.45E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.64|P-value:9.15E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.81|P-value:4.63E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:3.20|P-value:5.07E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.65|P-value:8.97E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.21|P-value:4.89E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.55|P-value:1.32E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.35|P-value:2.93E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:3.72|P-value:6.81E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:3.05|P-value:8.63E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.33|P-value:3.14E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.11|P-value:6.90E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.30|P-value:5.11E-6 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.13|P-value:6.45E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.00|P-value:1.99E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.47|P-value:2.23E-6 ID:SGTC_1666|Compound:st014829|FD-Score:3.65|P-value:8.86E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.46|P-value:1.93E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-4.82|P-value:3.74E-7 ID:SGTC_1717|Compound:st033143|FD-Score:-3.26|P-value:4.07E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.35|P-value:2.88E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.17|P-value:5.70E-4 ID:SGTC_1867|Compound:st057372|FD-Score:4.13|P-value:1.11E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.20|P-value:5.12E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.74|P-value:6.07E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.04|P-value:9.14E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.08|P-value:7.92E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.05|P-value:8.58E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.96|P-value:2.38E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.70|P-value:7.27E-5 ID:SGTC_2135|Compound:5326629|FD-Score:-4.57|P-value:1.38E-6 ID:SGTC_2136|Compound:5328288|FD-Score:3.49|P-value:1.69E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.39|P-value:2.46E-4 ID:SGTC_2351|Compound:9026858|FD-Score:5.21|P-value:4.37E-8 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.76|P-value:5.63E-5 ID:SGTC_2463|Compound:5473429|FD-Score:3.45|P-value:1.97E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.35|P-value:2.97E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.39|P-value:2.52E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.09|P-value:7.65E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:6.75|P-value:2.12E-12 ID:SGTC_2696|Compound:st077691|FD-Score:3.50|P-value:1.64E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.76|P-value:5.67E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.20|P-value:5.02E-4 ID:SGTC_3026|Compound:9090633|FD-Score:-3.41|P-value:2.33E-4 ID:SGTC_3039|Compound:9090270|FD-Score:5.43|P-value:1.22E-8 ID:SGTC_3081|Compound:9117243|FD-Score:3.72|P-value:6.76E-5 ID:SGTC_3087|Compound:9117406|FD-Score:-3.68|P-value:7.93E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.27|P-value:3.88E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.81|P-value:4.59E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.29|P-value:3.71E-4 ID:SGTC_3346|Compound:9158254|FD-Score:5.12|P-value:7.46E-8 ID:SGTC_35|Compound:0133-0054|FD-Score:4.45|P-value:2.50E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:3.23|P-value:4.49E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:5.25|P-value:3.44E-8 ID:SGTC_166|Compound:k072-0058|FD-Score:5.00|P-value:1.43E-7 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.21|P-value:4.86E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.17|P-value:5.71E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.53|P-value:1.45E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.64|P-value:9.15E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.81|P-value:4.63E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:3.20|P-value:5.07E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.65|P-value:8.97E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.21|P-value:4.89E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.55|P-value:1.32E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.35|P-value:2.93E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:3.72|P-value:6.81E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:3.05|P-value:8.63E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.33|P-value:3.14E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.11|P-value:6.90E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.30|P-value:5.11E-6 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.13|P-value:6.45E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.00|P-value:1.99E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.47|P-value:2.23E-6 ID:SGTC_1666|Compound:st014829|FD-Score:3.65|P-value:8.86E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.46|P-value:1.93E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-4.82|P-value:3.74E-7 ID:SGTC_1717|Compound:st033143|FD-Score:-3.26|P-value:4.07E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.35|P-value:2.88E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.17|P-value:5.70E-4 ID:SGTC_1867|Compound:st057372|FD-Score:4.13|P-value:1.11E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.20|P-value:5.12E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.74|P-value:6.07E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.04|P-value:9.14E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.08|P-value:7.92E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.05|P-value:8.58E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.96|P-value:2.38E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.70|P-value:7.27E-5 ID:SGTC_2135|Compound:5326629|FD-Score:-4.57|P-value:1.38E-6 ID:SGTC_2136|Compound:5328288|FD-Score:3.49|P-value:1.69E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.39|P-value:2.46E-4 ID:SGTC_2351|Compound:9026858|FD-Score:5.21|P-value:4.37E-8 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.76|P-value:5.63E-5 ID:SGTC_2463|Compound:5473429|FD-Score:3.45|P-value:1.97E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.35|P-value:2.97E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.39|P-value:2.52E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.09|P-value:7.65E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:6.75|P-value:2.12E-12 ID:SGTC_2696|Compound:st077691|FD-Score:3.50|P-value:1.64E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.76|P-value:5.67E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.20|P-value:5.02E-4 ID:SGTC_3026|Compound:9090633|FD-Score:-3.41|P-value:2.33E-4 ID:SGTC_3039|Compound:9090270|FD-Score:5.43|P-value:1.22E-8 ID:SGTC_3081|Compound:9117243|FD-Score:3.72|P-value:6.76E-5 ID:SGTC_3087|Compound:9117406|FD-Score:-3.68|P-value:7.93E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.27|P-value:3.88E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.81|P-value:4.59E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.29|P-value:3.71E-4 ID:SGTC_3346|Compound:9158254|FD-Score:5.12|P-value:7.46E-8

Top fitness defect scores for YNL122C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2684 capsaicin 6.75 100.0 µM 2.12E-12 4 7.46E-12
2 SGTC_3039 9090270 5.43 49.5 µM 1.22E-8 RPP1 & pyrimidine depletion 3 2.77E-8
3 SGTC_164 4100-3994 5.25 89.6 µM 3.44E-8 10 7.43E-8
4 SGTC_2351 9026858 5.21 72.3 µM 4.37E-8 RNA processing & uracil transport 8 9.33E-8
5 SGTC_3346 9158254 5.12 43.6 µM 7.46E-8 3 1.55E-7
6 SGTC_166 k072-0058 5.00 166.4 µM 1.43E-7 DNA intercalators 17 2.87E-7
7 SGTC_1631 benzylvanillin 4.47 81.9 µM 2.23E-6 Golgi 18 3.91E-6
8 SGTC_35 0133-0054 4.45 64.1 µM 2.50E-6 20 4.37E-6
9 SGTC_1333 1482-0047 4.30 286.0 µM 5.11E-6 11 8.62E-6
10 SGTC_1867 st057372 4.13 64.0 µM 1.11E-5 7 1.80E-5
11 SGTC_1551 6-bromo-3'-methylflavone 4.00 63.5 µM 1.99E-5 11 3.14E-5
12 SGTC_2129 girgensonine 3.96 121.0 µM 2.38E-5 heme biosynthesis & mitochondrial translocase 29 3.73E-5
13 SGTC_3299 9121982 3.81 43.1 µM 4.59E-5 37 6.94E-5
14 SGTC_2761 levamisole 3.76 97.9 µM 5.67E-5 20 8.50E-5
15 SGTC_1958 st076513 3.74 41.9 µM 6.07E-5 60S ribosome export 35 9.06E-5
16 SGTC_3081 9117243 3.72 49.5 µM 6.76E-5 fatty acid desaturase (OLE1) 22 1.00E-4
17 SGTC_858 0438-0351 3.72 2.8 µM 6.81E-5 copper-dependent oxidative stress 26 1.01E-4
18 SGTC_2130 NSC 7 3.70 2.5 µM 7.27E-5 copper-dependent oxidative stress 35 1.08E-4
19 SGTC_1666 st014829 3.65 29.0 µM 8.86E-5 calcium & mitochondrial duress 32 1.30E-4
20 SGTC_730 1436-0052 3.65 41.2 µM 8.97E-5 mitochondrial processes 17 1.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.48E-8 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.097 1.64E-8 YNL159C ASI2 hom Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
0.087 4.11E-7 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
0.084 1.09E-6 YJL133W MRS3 hom Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication
0.084 1.28E-6 YBR162W-A YSY6 hom Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
0.083 1.43E-6 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.082 1.88E-6 YOR147W MDM32 hom Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
0.082 2.05E-6 YIL141W_d YIL141W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.69E-6 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.080 3.61E-6 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.076 1.05E-5 YJR130C STR2 hom Cystathionine gamma-synthase, converts cysteine into cystathionine
0.073 2.17E-5 YKR097W PCK1 hom Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
0.073 2.32E-5 YJR134C SGM1 hom Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus
0.072 2.64E-5 YMR265C_p YMR265C_p hom Putative protein of unknown function
0.072 3.15E-5 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants