YNL125C / ESBP6

Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL125C / ESBP6

Click on Significant Values for Screen Details ID:SGTC_364|Compound:0083-0097|FD-Score:-3.05|P-value:8.83E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.42|P-value:2.23E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.63|P-value:9.87E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.02|P-value:9.89E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.54|P-value:1.45E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.18|P-value:5.57E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.55|P-value:1.37E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.15|P-value:6.16E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:-4.06|P-value:1.57E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.36|P-value:2.80E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.23|P-value:4.65E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.67|P-value:8.32E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:4.21|P-value:8.08E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.15|P-value:1.02E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:5.42|P-value:1.36E-8 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.60|P-value:1.12E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.17|P-value:5.67E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.03|P-value:9.31E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.58|P-value:1.22E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.11|P-value:7.18E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-4.19|P-value:8.61E-6 ID:SGTC_2000|Compound:st075254|FD-Score:-3.82|P-value:4.36E-5 ID:SGTC_2094|Compound:5332512|FD-Score:3.22|P-value:4.89E-4 ID:SGTC_2111|Compound:5486399|FD-Score:-3.32|P-value:3.31E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.45|P-value:2.06E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.81|P-value:4.59E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.23|P-value:4.59E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.64|P-value:9.99E-7 ID:SGTC_2379|Compound:9035213|FD-Score:3.32|P-value:3.36E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.26|P-value:4.14E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.21|P-value:5.01E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.05|P-value:8.70E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.08|P-value:1.45E-5 ID:SGTC_2625|Compound:euphol|FD-Score:4.92|P-value:2.20E-7 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.25|P-value:4.24E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.45|P-value:1.98E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.08|P-value:7.76E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-4.89|P-value:2.56E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:3.24|P-value:4.47E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.13|P-value:6.70E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.11|P-value:7.21E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.05|P-value:8.86E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.72|P-value:6.81E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-4.90|P-value:2.46E-7 ID:SGTC_2986|Compound:9022445|FD-Score:3.94|P-value:2.72E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.05|P-value:8.98E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.16|P-value:5.93E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.48|P-value:1.77E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.09|P-value:7.73E-4 ID:SGTC_3070|Compound:9117005|FD-Score:-3.02|P-value:9.69E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-4.62|P-value:1.04E-6 ID:SGTC_3077|Compound:9117319|FD-Score:-3.06|P-value:8.27E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.28|P-value:3.82E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.13|P-value:6.65E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.05|P-value:8.71E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.45|P-value:2.03E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.05|P-value:8.83E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.42|P-value:2.23E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.63|P-value:9.87E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.02|P-value:9.89E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.54|P-value:1.45E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.18|P-value:5.57E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.55|P-value:1.37E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.15|P-value:6.16E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:-4.06|P-value:1.57E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.36|P-value:2.80E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.23|P-value:4.65E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.67|P-value:8.32E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:4.21|P-value:8.08E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.15|P-value:1.02E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:5.42|P-value:1.36E-8 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.60|P-value:1.12E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.17|P-value:5.67E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.03|P-value:9.31E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.58|P-value:1.22E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.11|P-value:7.18E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-4.19|P-value:8.61E-6 ID:SGTC_2000|Compound:st075254|FD-Score:-3.82|P-value:4.36E-5 ID:SGTC_2094|Compound:5332512|FD-Score:3.22|P-value:4.89E-4 ID:SGTC_2111|Compound:5486399|FD-Score:-3.32|P-value:3.31E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.45|P-value:2.06E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.81|P-value:4.59E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.23|P-value:4.59E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.64|P-value:9.99E-7 ID:SGTC_2379|Compound:9035213|FD-Score:3.32|P-value:3.36E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.26|P-value:4.14E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.21|P-value:5.01E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.05|P-value:8.70E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.08|P-value:1.45E-5 ID:SGTC_2625|Compound:euphol|FD-Score:4.92|P-value:2.20E-7 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.25|P-value:4.24E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.45|P-value:1.98E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.08|P-value:7.76E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-4.89|P-value:2.56E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:3.24|P-value:4.47E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.13|P-value:6.70E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.11|P-value:7.21E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.05|P-value:8.86E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.72|P-value:6.81E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-4.90|P-value:2.46E-7 ID:SGTC_2986|Compound:9022445|FD-Score:3.94|P-value:2.72E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.05|P-value:8.98E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.16|P-value:5.93E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.48|P-value:1.77E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.09|P-value:7.73E-4 ID:SGTC_3070|Compound:9117005|FD-Score:-3.02|P-value:9.69E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-4.62|P-value:1.04E-6 ID:SGTC_3077|Compound:9117319|FD-Score:-3.06|P-value:8.27E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.28|P-value:3.82E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.13|P-value:6.65E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.05|P-value:8.71E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.45|P-value:2.03E-4

Top fitness defect scores for YNL125C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1451 4152-0210 5.42 104.0 µM 1.36E-8 5 2.97E-8
2 SGTC_2625 euphol 4.92 100.0 µM 2.20E-7 16 4.22E-7
3 SGTC_2320 7373003 4.64 200.0 µM 9.99E-7 10 1.78E-6
4 SGTC_1305 1181-0477 4.21 144.0 µM 8.08E-6 12 1.30E-5
5 SGTC_1391 3442-0225 4.15 151.0 µM 1.02E-5 11 1.63E-5
6 SGTC_2617 dihydrotanshinone i 4.08 20.8 µM 1.45E-5 copper-dependent oxidative stress 41 2.27E-5
7 SGTC_2986 9022445 3.94 71.4 µM 2.72E-5 16 4.14E-5
8 SGTC_1185 1319-0113 3.67 81.3 µM 8.32E-5 DNA damage response 14 1.20E-4
9 SGTC_1475 4092-1048 3.60 11.7 µM 1.12E-4 plasma membrane duress 42 1.60E-4
10 SGTC_1929 genistein trimethyl ether 3.58 50.5 µM 1.22E-4 23 1.73E-4
11 SGTC_859 0439-0102 3.55 54.6 µM 1.37E-4 redox potentiating 21 1.94E-4
12 SGTC_746 1095-0025 3.54 46.6 µM 1.45E-4 RSC & ERG11 23 2.04E-4
13 SGTC_2162 5663267 3.45 200.0 µM 2.06E-4 23 2.85E-4
14 SGTC_405 ebelactone b 3.42 50.0 µM 2.23E-4 33 3.08E-4
15 SGTC_2379 9035213 3.32 200.0 µM 3.36E-4 47 4.56E-4
16 SGTC_3110 9122132 3.28 49.5 µM 3.82E-4 redox potentiating 35 5.15E-4
17 SGTC_2401 5128683 3.26 200.0 µM 4.14E-4 64 5.56E-4
18 SGTC_2629 bisabolol 3.25 100.0 µM 4.24E-4 51 5.69E-4
19 SGTC_2756 carbadox 3.24 75.1 µM 4.47E-4 95 5.98E-4
20 SGTC_2277 7947813 3.23 106.9 µM 4.59E-4 RSC complex & mRNA processing 55 6.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 3.36E-16 YLR037C PAU23 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.107 6.21E-10 YER169W RPH1 hom JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication
0.099 9.91E-9 YDL036C PUS9 hom Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence
0.088 3.11E-7 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.087 4.24E-7 YFL021W GAT1 hom Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
0.082 2.25E-6 YLR355C ILV5 het Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
0.080 3.09E-6 YFR025C HIS2 hom Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
0.078 5.67E-6 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.078 6.06E-6 YBR043C QDR3 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin
0.076 1.04E-5 YML109W ZDS2 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
0.074 1.81E-5 YGR032W GSC2 hom Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.074 1.95E-5 YDR250C_d YDR250C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.070 4.90E-5 YKR063C LAS1 het Protein required for pre-rRNA processing at both ends of ITS2; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S transition of the cell cycle; human ortholog is Las1L; mutants require the SSD1-v allele for viability
0.070 5.08E-5 YDR185C UPS3 hom Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
0.070 5.65E-5 YLR298C YHC1 het Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site