HIPHOP chemogenomics database

YNL125C / ESBP6

Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL125C / ESBP6

Click on Significant Values for Screen Details

Top fitness defect scores for YNL125C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1451	4152-0210	5.42	104.0 µM	1.36E-8		5	2.97E-8
2	SGTC_2625	euphol	4.92	100.0 µM	2.20E-7		16	4.22E-7
3	SGTC_2320	7373003	4.64	200.0 µM	9.99E-7		10	1.78E-6
4	SGTC_1305	1181-0477	4.21	144.0 µM	8.08E-6		12	1.30E-5
5	SGTC_1391	3442-0225	4.15	151.0 µM	1.02E-5		11	1.63E-5
6	SGTC_2617	dihydrotanshinone i	4.08	20.8 µM	1.45E-5	copper-dependent oxidative stress	41	2.27E-5
7	SGTC_2986	9022445	3.94	71.4 µM	2.72E-5		16	4.14E-5
8	SGTC_1185	1319-0113	3.67	81.3 µM	8.32E-5	DNA damage response	14	1.20E-4
9	SGTC_1475	4092-1048	3.60	11.7 µM	1.12E-4	plasma membrane duress	42	1.60E-4
10	SGTC_1929	genistein trimethyl ether	3.58	50.5 µM	1.22E-4		23	1.73E-4
11	SGTC_859	0439-0102	3.55	54.6 µM	1.37E-4	redox potentiating	21	1.94E-4
12	SGTC_746	1095-0025	3.54	46.6 µM	1.45E-4	RSC & ERG11	23	2.04E-4
13	SGTC_2162	5663267	3.45	200.0 µM	2.06E-4		23	2.85E-4
14	SGTC_405	ebelactone b	3.42	50.0 µM	2.23E-4		33	3.08E-4
15	SGTC_2379	9035213	3.32	200.0 µM	3.36E-4		47	4.56E-4
16	SGTC_3110	9122132	3.28	49.5 µM	3.82E-4	redox potentiating	35	5.15E-4
17	SGTC_2401	5128683	3.26	200.0 µM	4.14E-4		64	5.56E-4
18	SGTC_2629	bisabolol	3.25	100.0 µM	4.24E-4		51	5.69E-4
19	SGTC_2756	carbadox	3.24	75.1 µM	4.47E-4		95	5.98E-4
20	SGTC_2277	7947813	3.23	106.9 µM	4.59E-4	RSC complex & mRNA processing	55	6.13E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.140	3.36E-16	YLR037C	PAU23	hom	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.107	6.21E-10	YER169W	RPH1	hom	JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication
0.099	9.91E-9	YDL036C	PUS9	hom	Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence
0.088	3.11E-7	YDR020C_p	DAS2_p	hom	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.087	4.24E-7	YFL021W	GAT1	hom	Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
0.082	2.25E-6	YLR355C	ILV5	het	Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
0.080	3.09E-6	YFR025C	HIS2	hom	Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
0.078	5.67E-6	YGL210W	YPT32	hom	Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.078	6.06E-6	YBR043C	QDR3	hom	Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin
0.076	1.04E-5	YML109W	ZDS2	hom	Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
0.074	1.81E-5	YGR032W	GSC2	hom	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.074	1.95E-5	YDR250C_d	YDR250C_d	hom	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.070	4.90E-5	YKR063C	LAS1	het	Protein required for pre-rRNA processing at both ends of ITS2; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S transition of the cell cycle; human ortholog is Las1L; mutants require the SSD1-v allele for viability
0.070	5.08E-5	YDR185C	UPS3	hom	Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
0.070	5.65E-5	YLR298C	YHC1	het	Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site