YNL130C / CPT1

Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL130C / CPT1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:2.86|P-value:8.65E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:6.70|P-value:8.62E-14 ID:SGTC_67|Compound:0335-0847|FD-Score:3.63|P-value:3.50E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:3.13|P-value:2.99E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:3.33|P-value:1.31E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.06|P-value:3.31E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.53|P-value:5.48E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.96|P-value:7.04E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.06|P-value:3.31E-4 ID:SGTC_397|Compound:arbidol|FD-Score:2.84|P-value:9.44E-4 ID:SGTC_406|Compound:estrone|FD-Score:2.85|P-value:9.23E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-2.88|P-value:6.84E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.03|P-value:3.80E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-2.88|P-value:6.63E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-2.95|P-value:5.15E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.02|P-value:3.85E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:2.85|P-value:8.94E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.95|P-value:6.11E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.47|P-value:7.26E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:3.86|P-value:1.16E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:3.45|P-value:7.70E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:-2.89|P-value:6.44E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.52|P-value:3.45E-7 ID:SGTC_882|Compound:0843-0131|FD-Score:3.45|P-value:7.85E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:3.03|P-value:4.63E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.51|P-value:5.89E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.87|P-value:8.52E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-2.96|P-value:4.93E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:2.93|P-value:6.76E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.15|P-value:2.62E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.96|P-value:2.62E-8 ID:SGTC_1287|Compound:0971-0001|FD-Score:-2.85|P-value:7.44E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-2.98|P-value:4.63E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.07|P-value:3.25E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.20|P-value:2.26E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.63|P-value:3.43E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.28|P-value:1.67E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.74|P-value:1.63E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.56|P-value:3.79E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.12|P-value:3.20E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.24|P-value:1.96E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.70|P-value:1.27E-7 ID:SGTC_2700|Compound:st077718|FD-Score:-5.26|P-value:2.79E-9 ID:SGTC_2830|Compound:7992007|FD-Score:-3.42|P-value:7.05E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-3.28|P-value:1.31E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.04|P-value:4.40E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-4.44|P-value:4.24E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-3.03|P-value:3.74E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.12|P-value:3.22E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.08|P-value:3.80E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.03|P-value:3.74E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:2.86|P-value:8.65E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:6.70|P-value:8.62E-14 ID:SGTC_67|Compound:0335-0847|FD-Score:3.63|P-value:3.50E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:3.13|P-value:2.99E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:3.33|P-value:1.31E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.06|P-value:3.31E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.53|P-value:5.48E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.96|P-value:7.04E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.06|P-value:3.31E-4 ID:SGTC_397|Compound:arbidol|FD-Score:2.84|P-value:9.44E-4 ID:SGTC_406|Compound:estrone|FD-Score:2.85|P-value:9.23E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-2.88|P-value:6.84E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.03|P-value:3.80E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-2.88|P-value:6.63E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-2.95|P-value:5.15E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.02|P-value:3.85E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:2.85|P-value:8.94E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.95|P-value:6.11E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.47|P-value:7.26E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:3.86|P-value:1.16E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:3.45|P-value:7.70E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:-2.89|P-value:6.44E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.52|P-value:3.45E-7 ID:SGTC_882|Compound:0843-0131|FD-Score:3.45|P-value:7.85E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:3.03|P-value:4.63E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.51|P-value:5.89E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.87|P-value:8.52E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-2.96|P-value:4.93E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:2.93|P-value:6.76E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.15|P-value:2.62E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.96|P-value:2.62E-8 ID:SGTC_1287|Compound:0971-0001|FD-Score:-2.85|P-value:7.44E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-2.98|P-value:4.63E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.07|P-value:3.25E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.20|P-value:2.26E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.63|P-value:3.43E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.28|P-value:1.67E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.74|P-value:1.63E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.56|P-value:3.79E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.12|P-value:3.20E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.24|P-value:1.96E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.70|P-value:1.27E-7 ID:SGTC_2700|Compound:st077718|FD-Score:-5.26|P-value:2.79E-9 ID:SGTC_2830|Compound:7992007|FD-Score:-3.42|P-value:7.05E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-3.28|P-value:1.31E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.04|P-value:4.40E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-4.44|P-value:4.24E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-3.03|P-value:3.74E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.12|P-value:3.22E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.08|P-value:3.80E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.03|P-value:3.74E-4

Top fitness defect scores for YNL130C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_64 000l-0018 6.70 272.1 µM 8.62E-14 ubiquinone biosynthesis & proteasome 65 1.03E-11
2 SGTC_1270 0831-1170 4.96 17.3 µM 2.62E-8 3 3.58E-7
3 SGTC_2688 kanamycin b 4.70 96.7 µM 1.27E-7 calcium & mitochondrial duress 274 1.33E-6
4 SGTC_878 0828-0289 4.52 13.7 µM 3.45E-7 35 3.05E-6
5 SGTC_1248 0469-0687 4.15 58.6 µM 2.62E-6 22 1.65E-5
6 SGTC_310 1273-0058 3.96 1.1 µM 7.04E-6 mitochondrial stress 246 3.75E-5
7 SGTC_702 1488-0190 3.86 94.0 µM 1.16E-5 amide catabolism 16 5.70E-5
8 SGTC_1679 4130-1276 3.63 6.7 µM 3.43E-5 Golgi 81 1.41E-4
9 SGTC_67 0335-0847 3.63 266.0 µM 3.50E-5 ubiquinone biosynthesis & proteasome 139 1.43E-4
10 SGTC_216 k038-0035 3.53 28.4 µM 5.48E-5 ubiquinone biosynthesis & proteasome 60 2.08E-4
11 SGTC_959 1222-0044 3.51 107.0 µM 5.89E-5 32 2.21E-4
12 SGTC_700 3453-2283 3.47 142.0 µM 7.26E-5 amide catabolism 48 2.63E-4
13 SGTC_790 1575-0012 3.45 79.1 µM 7.70E-5 TSC3-RPN4 47 2.76E-4
14 SGTC_882 0843-0131 3.45 351.0 µM 7.85E-5 26 2.80E-4
15 SGTC_109 0132-0036 3.33 33.7 µM 1.31E-4 40 4.29E-4
16 SGTC_1714 st033236 3.28 13.6 µM 1.67E-4 50 5.28E-4
17 SGTC_2563 tomatine 3.24 8.5 µM 1.96E-4 87 6.02E-4
18 SGTC_1677 st019204 3.20 53.9 µM 2.26E-4 51 6.81E-4
19 SGTC_71 0417-1750 3.13 47.8 µM 2.99E-4 Golgi 94 8.59E-4
20 SGTC_2410 aloe-emodin-8-o-glycoside 3.12 46.3 µM 3.20E-4 mitochondrial processes 75 9.08E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 1.19E-40 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.224 2.60E-39 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.219 1.15E-37 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.218 2.32E-37 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.212 1.50E-35 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.212 1.77E-35 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.207 8.33E-34 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.202 3.47E-32 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.198 6.27E-31 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.191 4.90E-29 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.182 2.37E-26 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.179 1.29E-25 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.175 1.42E-24 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.174 2.63E-24 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.174 3.57E-24 YEL043W YEL043W hom Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold