Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YNL134C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.198 | 6.35E-31 | YFR026C | ULI1 | hom | Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response |
0.193 | 2.23E-29 | YGR083C | GCD2 | het | Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
0.174 | 3.50E-24 | YNL067W-B_p | YNL067W-B_p | hom | Putative protein of unknown function |
0.143 | 8.47E-17 | YNL056W | OCA2 | hom | Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene |
0.132 | 1.42E-14 | YER062C | HOR2 | hom | Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication |
0.129 | 5.32E-14 | YDR527W | RBA50 | het | Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 |
0.128 | 1.06E-13 | YDL009C_p | YDL009C_p | hom | Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene |
0.124 | 5.58E-13 | YCL063W | VAC17 | hom | Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p |
0.119 | 4.31E-12 | YPR153W | YPR153W | hom | Putative protein of unknown function |
0.112 | 6.75E-11 | YCR095C_p | OCA4_p | hom | Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts |
0.112 | 6.96E-11 | YOR066W | MSA1 | hom | Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation |
0.110 | 1.62E-10 | YNL001W | DOM34 | hom | Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication |
0.108 | 3.72E-10 | YER086W | ILV1 | hom | Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation |
0.108 | 4.09E-10 | YLR451W | LEU3 | hom | Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation |
0.107 | 5.57E-10 | YGR115C_d | YGR115C_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C |