YNL138W / SRV2

CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL138W / SRV2

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.69|P-value:3.92E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.87|P-value:2.06E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.83|P-value:2.36E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-3.87|P-value:5.20E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.77|P-value:1.04E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:3.57|P-value:5.82E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.55|P-value:6.33E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.43|P-value:9.45E-4 ID:SGTC_1702|Compound:st027038|FD-Score:-4.25|P-value:1.10E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.77|P-value:2.99E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-4.95|P-value:4.48E-7 ID:SGTC_1781|Compound:st038725|FD-Score:3.42|P-value:9.72E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.63|P-value:4.70E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.79|P-value:2.71E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.74|P-value:3.24E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.57|P-value:5.83E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.49|P-value:7.65E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.49|P-value:7.67E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.84|P-value:2.29E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.44|P-value:8.91E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.82|P-value:2.43E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.71|P-value:3.65E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.64|P-value:4.57E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.74|P-value:3.32E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.19|P-value:6.17E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.65|P-value:4.49E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.41|P-value:2.92E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.62|P-value:1.37E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.21|P-value:5.73E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.60|P-value:5.28E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.74|P-value:3.22E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.46|P-value:8.50E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.87|P-value:5.08E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.55|P-value:6.30E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.53|P-value:6.59E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.48|P-value:7.92E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.97|P-value:1.44E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-3.07|P-value:9.05E-4 ID:SGTC_3252|Compound:9135871|FD-Score:-3.19|P-value:6.14E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.69|P-value:3.92E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.87|P-value:2.06E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.83|P-value:2.36E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-3.87|P-value:5.20E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.77|P-value:1.04E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:3.57|P-value:5.82E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.55|P-value:6.33E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.43|P-value:9.45E-4 ID:SGTC_1702|Compound:st027038|FD-Score:-4.25|P-value:1.10E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.77|P-value:2.99E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-4.95|P-value:4.48E-7 ID:SGTC_1781|Compound:st038725|FD-Score:3.42|P-value:9.72E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.63|P-value:4.70E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.79|P-value:2.71E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.74|P-value:3.24E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.57|P-value:5.83E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.49|P-value:7.65E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.49|P-value:7.67E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.84|P-value:2.29E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.44|P-value:8.91E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.82|P-value:2.43E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.71|P-value:3.65E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.64|P-value:4.57E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.74|P-value:3.32E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.19|P-value:6.17E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.65|P-value:4.49E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.41|P-value:2.92E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.62|P-value:1.37E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.21|P-value:5.73E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.60|P-value:5.28E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.74|P-value:3.22E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.46|P-value:8.50E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.87|P-value:5.08E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.55|P-value:6.30E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.53|P-value:6.59E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.48|P-value:7.92E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.97|P-value:1.44E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-3.07|P-value:9.05E-4 ID:SGTC_3252|Compound:9135871|FD-Score:-3.19|P-value:6.14E-4

Top fitness defect scores for YNL138W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2663 amphotericin b 4.19 100.0 µM 6.17E-5 9 1.40E-5
2 SGTC_3041 9091929 3.97 49.5 µM 1.44E-4 redox potentiating 20 3.65E-5
3 SGTC_93 0109-0045 3.87 59.2 µM 2.06E-4 DNA damage response 51 5.46E-5
4 SGTC_2366 9070441 3.84 60.6 µM 2.29E-4 34 6.16E-5
5 SGTC_156 3474-0145 3.83 5.6 µM 2.36E-4 endomembrane recycling 54 6.39E-5
6 SGTC_2379 9035213 3.82 200.0 µM 2.43E-4 23 6.59E-5
7 SGTC_1922 5578187 3.79 25.0 µM 2.71E-4 TRP & mitochondrial translation 41 7.45E-5
8 SGTC_1713 st033146 3.77 12.8 µM 2.99E-4 33 8.32E-5
9 SGTC_2817 7995342 3.74 71.4 µM 3.22E-4 31 9.07E-5
10 SGTC_1925 st057770 3.74 10.1 µM 3.24E-4 TSC3-RPN4 23 9.12E-5
11 SGTC_2611 pyromycin 3.74 23.9 µM 3.32E-4 31 9.38E-5
12 SGTC_2432 5630864 3.71 12.2 µM 3.65E-4 31 1.04E-4
13 SGTC_21 0849-0113 3.69 23.0 µM 3.92E-4 37 1.13E-4
14 SGTC_2749 bexarotene 3.65 57.4 µM 4.49E-4 34 1.32E-4
15 SGTC_2606 farnesol 3.64 9.8 µM 4.57E-4 28 1.35E-4
16 SGTC_1896 st058441 3.63 89.0 µM 4.70E-4 20 1.39E-4
17 SGTC_2785 7756463 3.60 72.7 µM 5.28E-4 39 1.59E-4
18 SGTC_936 3005-4620 3.57 401.0 µM 5.82E-4 36 1.77E-4
19 SGTC_1985 st071382 3.57 65.5 µM 5.83E-4 28 1.78E-4
20 SGTC_2991 9074669 3.55 71.4 µM 6.30E-4 azole & statin 82 1.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.093 7.90E-8 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.081 2.69E-6 YKR012C_d YKR012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
0.079 4.93E-6 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.078 5.42E-6 YOR149C SMP3 het Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.078 5.70E-6 YNL034W_p YNL034W_p hom Putative protein of unknown function; YNL034W is not an essential gene
0.077 9.12E-6 YER015W FAA2 hom Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome
0.076 1.05E-5 YER170W ADK2 hom Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
0.075 1.48E-5 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.073 2.53E-5 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.072 3.31E-5 YJL075C_d APQ13_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate
0.070 4.75E-5 YBR183W YPC1 hom Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication
0.069 5.86E-5 YIL141W_d YIL141W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.069 6.89E-5 YLR109W AHP1 hom Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
0.068 8.52E-5 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.068 8.56E-5 YER056C FCY2 hom Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress