HIPHOP chemogenomics database

YNL184C_p

Protein of unknown function; expressed at both mRNA and protein levels

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL184C / YNL184C

Click on Significant Values for Screen Details

Top fitness defect scores for YNL184C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	23.90	5.3 µM	1.19E-98		37	1.62E-126
2	SGTC_275	trichlorophene	10.70	5.7 µM	2.72E-21	mitochondrial stress	37	8.23E-27
3	SGTC_173	1273-0061	9.91	2.7 µM	1.10E-18	mitochondrial stress	40	1.85E-23
4	SGTC_2582	agaric acid	9.55	100.0 µM	1.70E-17	redox potentiating	76	6.21E-22
5	SGTC_310	1273-0058	9.29	1.1 µM	1.20E-16	mitochondrial stress	56	7.69E-21
6	SGTC_58	0957-0393	9.05	9.0 µM	7.05E-16	cell wall	95	7.44E-20
7	SGTC_908	3448-7491	7.99	47.7 µM	8.41E-13	mitochondrial stress	17	6.59E-16
8	SGTC_1883	5-benzylidenerhodanine	6.92	20.0 µM	4.86E-10	TRP & mitochondrial translation	15	2.28E-12
9	SGTC_1623	st003709	6.42	20.3 µM	7.10E-9	calcium & mitochondrial duress	10	7.03E-11
10	SGTC_903	1134-0042	5.12	114.0 µM	2.98E-6		8	1.56E-7
11	SGTC_876	0720-0963	5.11	56.8 µM	3.05E-6		5	1.61E-7
12	SGTC_2352	9027995	5.00	87.8 µM	4.75E-6	tubulin folding & SWR complex	20	2.83E-7
13	SGTC_386	1509-0011	5.00	3.1 µM	4.87E-6		108	2.93E-7
14	SGTC_791	1348-1292	4.99	225.0 µM	5.01E-6		18	3.03E-7
15	SGTC_63	0099-0242	4.88	26.7 µM	7.78E-6	mitochondrial stress	61	5.30E-7
16	SGTC_1742	st038235	4.86	28.9 µM	8.32E-6	mitochondrial stress	84	5.77E-7
17	SGTC_1622	st003707	4.81	19.4 µM	1.03E-5	calcium & mitochondrial duress	19	7.62E-7
18	SGTC_10	0279-0212	4.76	42.6 µM	1.24E-5	TRP & mitochondrial translation	73	9.58E-7
19	SGTC_2232	chlorophetanol	4.63	41.5 µM	2.06E-5	TRP & mitochondrial translation	97	1.83E-6
20	SGTC_2926	9010726	4.57	65.2 µM	2.62E-5		22	2.48E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.546	2.23E-260	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.539	1.75E-252	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.519	1.93E-231	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit
0.510	1.52E-220	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.506	1.70E-217	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.505	1.29E-216	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.503	4.17E-214	YMR098C	ATP25	hom	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.498	5.48E-210	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.498	1.42E-209	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.492	5.19E-204	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.491	1.04E-202	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.483	9.71E-196	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.479	5.27E-192	YNL177C	MRPL22	hom	Mitochondrial ribosomal protein of the large subunit
0.478	5.99E-191	YGL064C	MRH4	hom	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.473	1.78E-186	YCR071C	IMG2	hom	Mitochondrial ribosomal protein of the large subunit