YNL243W / SLA2

Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL243W / SLA2

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:-3.85|P-value:3.93E-5 ID:SGTC_101|Compound:0490-5701|FD-Score:-4.68|P-value:7.96E-7 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.20|P-value:8.16E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.20|P-value:5.05E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-3.41|P-value:2.36E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-3.56|P-value:1.29E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.90|P-value:3.14E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:-4.09|P-value:1.39E-5 ID:SGTC_2194|Compound:5927483|FD-Score:3.06|P-value:9.49E-4 ID:SGTC_2223|Compound:6903751|FD-Score:-4.27|P-value:5.90E-6 ID:SGTC_2276|Compound:7947513|FD-Score:-3.41|P-value:2.31E-4 ID:SGTC_2278|Compound:7948257|FD-Score:-3.02|P-value:9.53E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.17|P-value:5.76E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.26|P-value:4.04E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-3.37|P-value:2.70E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.85|P-value:3.93E-5 ID:SGTC_101|Compound:0490-5701|FD-Score:-4.68|P-value:7.96E-7 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.20|P-value:8.16E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.20|P-value:5.05E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-3.41|P-value:2.36E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-3.56|P-value:1.29E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.90|P-value:3.14E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:-4.09|P-value:1.39E-5 ID:SGTC_2194|Compound:5927483|FD-Score:3.06|P-value:9.49E-4 ID:SGTC_2223|Compound:6903751|FD-Score:-4.27|P-value:5.90E-6 ID:SGTC_2276|Compound:7947513|FD-Score:-3.41|P-value:2.31E-4 ID:SGTC_2278|Compound:7948257|FD-Score:-3.02|P-value:9.53E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.17|P-value:5.76E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.26|P-value:4.04E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-3.37|P-value:2.70E-4

Top fitness defect scores for YNL243W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2194 5927483 3.06 104.5 µM 9.49E-4 49 0.00111
2 SGTC_3249 9135183 2.94 49.5 µM 0.00144 60S ribosome export 63 0.00166
3 SGTC_3041 9091929 2.94 49.5 µM 0.00145 redox potentiating 64 0.00166
4 SGTC_1822 st052468 2.90 42.0 µM 0.00162 42 0.00186
5 SGTC_333 3486-0131 2.81 40.1 µM 0.00215 amide catabolism 47 0.00244
6 SGTC_2552 juarezic acid 2.81 87.0 µM 0.00219 TSC3-RPN4 104 0.00248
7 SGTC_2360 9040895 2.80 200.0 µM 0.00228 RPP1 & pyrimidine depletion 77 0.00258
8 SGTC_1761 st044296 2.79 37.0 µM 0.00230 59 0.00260
9 SGTC_1824 st053723 2.78 68.6 µM 0.00237 95 0.00268
10 SGTC_1663 st014140 2.77 55.4 µM 0.00247 60S ribosome export 84 0.00279
11 SGTC_1206 3978-0017 2.76 132.0 µM 0.00252 ERG2 92 0.00285
12 SGTC_1820 st053765 2.75 18.6 µM 0.00264 RPP1 & pyrimidine depletion 85 0.00297
13 SGTC_2971 9092186 2.74 9.9 µM 0.00271 ergosterol biosynthesis 87 0.00305
14 SGTC_2937 9044753 2.73 11.3 µM 0.00282 60S ribosome export 115 0.00318
15 SGTC_1633 st005664 2.72 67.9 µM 0.00290 120 0.00326
16 SGTC_3246 9135460 2.72 33.0 µM 0.00292 40 0.00328
17 SGTC_2043 5101342 2.71 149.0 µM 0.00302 SWF1 & branched chain AA biosynthesis 86 0.00339
18 SGTC_2177 5811945 2.71 192.0 µM 0.00303 83 0.00341
19 SGTC_2437 5741531 2.70 144.2 µM 0.00309 105 0.00347
20 SGTC_2420 aureobasidin a 2.67 50.0 nM 0.00336 130 0.00376

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.12E-9 YJL128C PBS2 hom MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition
0.096 2.37E-8 YER036C ARB1 het ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
0.095 3.28E-8 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes
0.094 4.19E-8 YLR103C CDC45 het DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
0.090 1.79E-7 YDL015C TSC13 het Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
0.086 5.54E-7 YNL155W YNL155W hom Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress
0.081 2.44E-6 YER020W GPA2 hom Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.079 4.10E-6 YLR338W_d OPI9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C
0.077 6.99E-6 YBR301W PAU24 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.077 8.21E-6 YDR370C DXO1 hom Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p
0.076 9.73E-6 YHR094C HXT1 hom Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication
0.074 2.01E-5 YNL141W AAH1 hom Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
0.073 2.32E-5 YKR060W UTP30 hom Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit
0.068 9.21E-5 YDR003W RCR2 hom Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.067 1.03E-4 YBR087W RFC5 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon