YNL253W / TEX1

Protein involved in mRNA export, component of the transcription export (TREX) complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL253W / TEX1

Click on Significant Values for Screen Details ID:SGTC_736|Compound:0958-0254|FD-Score:3.74|P-value:5.71E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:4.93|P-value:1.95E-7 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.05|P-value:9.88E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.94|P-value:2.43E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.05|P-value:8.09E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.96|P-value:2.28E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.02|P-value:1.72E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.39|P-value:2.35E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.11|P-value:8.05E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.47|P-value:2.13E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.48|P-value:1.67E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.38|P-value:2.43E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.76|P-value:2.13E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.24|P-value:4.99E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.28|P-value:3.59E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.27|P-value:3.71E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.48|P-value:1.63E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.56|P-value:1.21E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.67|P-value:7.64E-5 ID:SGTC_1706|Compound:st031321|FD-Score:-4.06|P-value:1.82E-5 ID:SGTC_1849|Compound:st056239|FD-Score:-3.13|P-value:7.34E-4 ID:SGTC_2010|Compound:4012422|FD-Score:4.56|P-value:1.29E-6 ID:SGTC_2113|Compound:5491891|FD-Score:3.13|P-value:6.13E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-4.24|P-value:7.87E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.49|P-value:1.09E-8 ID:SGTC_2438|Compound:5259590|FD-Score:-3.18|P-value:6.12E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.26|P-value:5.75E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.70|P-value:8.38E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.07|P-value:7.73E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.43|P-value:1.97E-4 ID:SGTC_3084|Compound:9116877|FD-Score:4.40|P-value:2.91E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.41|P-value:2.18E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.20|P-value:4.71E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.04|P-value:8.42E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.16|P-value:6.51E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.24|P-value:4.19E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-4.00|P-value:2.38E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.74|P-value:5.71E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:4.93|P-value:1.95E-7 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.05|P-value:9.88E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.94|P-value:2.43E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.05|P-value:8.09E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.96|P-value:2.28E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.02|P-value:1.72E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.39|P-value:2.35E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.11|P-value:8.05E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.47|P-value:2.13E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.48|P-value:1.67E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.38|P-value:2.43E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.76|P-value:2.13E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.24|P-value:4.99E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.28|P-value:3.59E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.27|P-value:3.71E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.48|P-value:1.63E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.56|P-value:1.21E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.67|P-value:7.64E-5 ID:SGTC_1706|Compound:st031321|FD-Score:-4.06|P-value:1.82E-5 ID:SGTC_1849|Compound:st056239|FD-Score:-3.13|P-value:7.34E-4 ID:SGTC_2010|Compound:4012422|FD-Score:4.56|P-value:1.29E-6 ID:SGTC_2113|Compound:5491891|FD-Score:3.13|P-value:6.13E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-4.24|P-value:7.87E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.49|P-value:1.09E-8 ID:SGTC_2438|Compound:5259590|FD-Score:-3.18|P-value:6.12E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.26|P-value:5.75E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.70|P-value:8.38E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.07|P-value:7.73E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.43|P-value:1.97E-4 ID:SGTC_3084|Compound:9116877|FD-Score:4.40|P-value:2.91E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.41|P-value:2.18E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.20|P-value:4.71E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.04|P-value:8.42E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.16|P-value:6.51E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.24|P-value:4.19E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-4.00|P-value:2.38E-5

Top fitness defect scores for YNL253W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_745 0469-0705 4.93 296.0 µM 1.95E-7 mitochondrial processes 9 4.16E-7
2 SGTC_2010 4012422 4.56 159.0 µM 1.29E-6 9 2.50E-6
3 SGTC_3084 9116877 4.40 49.5 µM 2.91E-6 5 5.41E-6
4 SGTC_2563 tomatine 4.26 8.5 µM 5.75E-6 32 1.03E-5
5 SGTC_1207 2099-0101 4.02 141.0 µM 1.72E-5 17 2.93E-5
6 SGTC_1203 3992-3522 3.96 103.0 µM 2.28E-5 33 3.82E-5
7 SGTC_992 3909-8734 3.94 162.0 µM 2.43E-5 21 4.07E-5
8 SGTC_736 0958-0254 3.74 92.6 µM 5.71E-5 Golgi 39 9.14E-5
9 SGTC_1700 st030840 3.67 7.9 µM 7.64E-5 PDR1 24 1.21E-4
10 SGTC_1698 5-fluorocytosine 3.56 1.1 µM 1.21E-4 exosome 13 1.86E-4
11 SGTC_1498 4478-3555 3.48 97.6 µM 1.63E-4 11 2.48E-4
12 SGTC_1246 0422-0085 3.48 105.0 µM 1.67E-4 52 2.54E-4
13 SGTC_2570 licareol 3.43 100.0 µM 1.97E-4 51 2.97E-4
14 SGTC_3173 9105693 3.41 49.5 µM 2.18E-4 41 3.27E-4
15 SGTC_1210 3013-0140 3.39 750.0 nM 2.35E-4 17 3.50E-4
16 SGTC_1369 1866-0067 3.38 208.0 µM 2.43E-4 RPP1 & pyrimidine depletion 62 3.62E-4
17 SGTC_1479 0549-0158 3.28 134.0 µM 3.59E-4 63 5.25E-4
18 SGTC_1490 4089-0339 3.27 670.0 nM 3.71E-4 20 5.42E-4
19 SGTC_3327 9140648 3.24 26.9 µM 4.19E-4 26 6.08E-4
20 SGTC_3181 9108277 3.20 49.5 µM 4.71E-4 iron homeostasis 44 6.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 1.16E-38 YBR239C_p ERT1_p hom Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition
0.205 4.95E-33 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.202 4.17E-32 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.201 5.02E-32 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.190 1.20E-28 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.183 1.43E-26 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.180 6.97E-26 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.176 7.03E-25 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.169 6.21E-23 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.167 2.10E-22 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.165 5.89E-22 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.165 5.76E-22 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.162 4.96E-21 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.161 6.09E-21 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.156 7.97E-20 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress