YNL297C / MON2

Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL297C / MON2

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:-3.38|P-value:3.14E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.39|P-value:2.99E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.42|P-value:2.77E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-5.38|P-value:3.88E-8 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.88|P-value:4.68E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:-5.48|P-value:2.15E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:-3.16|P-value:6.75E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.31|P-value:4.11E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.56|P-value:1.46E-21 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.77|P-value:7.25E-5 ID:SGTC_493|Compound:zm226600|FD-Score:-4.30|P-value:7.91E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.07|P-value:9.35E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:-3.43|P-value:2.65E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.12|P-value:7.82E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.59|P-value:1.48E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-4.71|P-value:1.20E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.37|P-value:3.25E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.13|P-value:7.63E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.69|P-value:9.93E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.86|P-value:5.01E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:-5.66|P-value:7.87E-9 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.57|P-value:1.57E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.54|P-value:2.59E-6 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.58|P-value:1.51E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:-8.70|P-value:3.16E-18 ID:SGTC_1179|Compound:1021-1431|FD-Score:-4.61|P-value:1.88E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:-6.01|P-value:1.01E-9 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.83|P-value:5.59E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:-4.14|P-value:1.56E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:-4.04|P-value:2.44E-5 ID:SGTC_1591|Compound:genipin|FD-Score:-3.92|P-value:3.95E-5 ID:SGTC_1923|Compound:st058458|FD-Score:-5.81|P-value:3.38E-9 ID:SGTC_1930|Compound:st074634|FD-Score:-3.54|P-value:1.78E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-5.29|P-value:6.18E-8 ID:SGTC_1938|Compound:st074717|FD-Score:-3.32|P-value:3.92E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-5.80|P-value:3.52E-9 ID:SGTC_1956|Compound:st077085|FD-Score:3.82|P-value:1.37E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.35|P-value:7.46E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.36|P-value:7.16E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.52|P-value:4.12E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.62|P-value:2.95E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.28|P-value:9.63E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-4.71|P-value:1.19E-6 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.39|P-value:3.01E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.84|P-value:1.27E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.98|P-value:7.57E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.44|P-value:5.52E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.74|P-value:1.90E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.38|P-value:3.14E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.39|P-value:2.99E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.42|P-value:2.77E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-5.38|P-value:3.88E-8 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.88|P-value:4.68E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:-5.48|P-value:2.15E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:-3.16|P-value:6.75E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.31|P-value:4.11E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.56|P-value:1.46E-21 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.77|P-value:7.25E-5 ID:SGTC_493|Compound:zm226600|FD-Score:-4.30|P-value:7.91E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.07|P-value:9.35E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:-3.43|P-value:2.65E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.12|P-value:7.82E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.59|P-value:1.48E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-4.71|P-value:1.20E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.37|P-value:3.25E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.13|P-value:7.63E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.69|P-value:9.93E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.86|P-value:5.01E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:-5.66|P-value:7.87E-9 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.57|P-value:1.57E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.54|P-value:2.59E-6 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.58|P-value:1.51E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:-8.70|P-value:3.16E-18 ID:SGTC_1179|Compound:1021-1431|FD-Score:-4.61|P-value:1.88E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:-6.01|P-value:1.01E-9 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.83|P-value:5.59E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:-4.14|P-value:1.56E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:-4.04|P-value:2.44E-5 ID:SGTC_1591|Compound:genipin|FD-Score:-3.92|P-value:3.95E-5 ID:SGTC_1923|Compound:st058458|FD-Score:-5.81|P-value:3.38E-9 ID:SGTC_1930|Compound:st074634|FD-Score:-3.54|P-value:1.78E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-5.29|P-value:6.18E-8 ID:SGTC_1938|Compound:st074717|FD-Score:-3.32|P-value:3.92E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-5.80|P-value:3.52E-9 ID:SGTC_1956|Compound:st077085|FD-Score:3.82|P-value:1.37E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.35|P-value:7.46E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.36|P-value:7.16E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.52|P-value:4.12E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.62|P-value:2.95E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.28|P-value:9.63E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-4.71|P-value:1.19E-6 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.39|P-value:3.01E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.84|P-value:1.27E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.98|P-value:7.57E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.44|P-value:5.52E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.74|P-value:1.90E-4

Top fitness defect scores for YNL297C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2627 acetyl isogambogic acid 3.98 100.0 µM 7.57E-5 TSC3-RPN4 41 3.47E-5
2 SGTC_2540 epiandrosterone 3.84 100.0 µM 1.27E-4 62 6.04E-5
3 SGTC_1956 st077085 3.82 54.0 µM 1.37E-4 21 6.54E-5
4 SGTC_3216 9129716 3.74 49.5 µM 1.90E-4 RPP1 & pyrimidine depletion 29 9.28E-5
5 SGTC_2144 5628481 3.62 200.0 µM 2.95E-4 ERG2 32 1.48E-4
6 SGTC_2119 5528445 3.52 120.6 µM 4.12E-4 37 2.12E-4
7 SGTC_3211 9128781 3.44 49.5 µM 5.52E-4 92 2.89E-4
8 SGTC_2064 5220758 3.36 200.0 µM 7.16E-4 65 3.83E-4
9 SGTC_2030 5175110 3.35 200.0 µM 7.46E-4 Golgi 43 4.00E-4
10 SGTC_2341 7987486 3.28 176.7 µM 9.63E-4 39 5.26E-4
11 SGTC_155 k072-0202 3.22 43.6 µM 0.00114 40 6.31E-4
12 SGTC_198 3454-2873 3.22 16.2 µM 0.00116 60S ribosome export 33 6.44E-4
13 SGTC_2010 4012422 3.21 159.0 µM 0.00121 54 6.72E-4
14 SGTC_2136 5328288 3.21 199.3 µM 0.00122 38 6.74E-4
15 SGTC_2188 6126565 3.04 140.7 µM 0.00204 mitochondrial processes 37 0.00117
16 SGTC_3235 9132602 3.03 49.5 µM 0.00213 74 0.00123
17 SGTC_1665 st014639 3.00 11.4 µM 0.00230 NEO1 67 0.00133
18 SGTC_1772 st048439 2.98 82.2 µM 0.00250 80 0.00146
19 SGTC_2483 5729050 2.93 27.2 µM 0.00284 76 0.00167
20 SGTC_2280 7785178 2.92 200.0 µM 0.00300 41 0.00178

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 6.08E-17 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.127 1.43E-13 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.108 3.44E-10 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.107 5.36E-10 YAL047C SPC72 hom Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
0.095 3.58E-8 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.095 4.10E-8 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.093 5.97E-8 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.091 1.35E-7 YML094W GIM5 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.090 1.70E-7 YGR085C RPL11B hom Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication
0.089 2.56E-7 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
0.083 1.59E-6 YEL044W IES6 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes
0.082 2.09E-6 YMR078C CTF18 hom Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
0.081 2.81E-6 YGR262C BUD32 hom Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription
0.080 3.15E-6 YNL256W FOL1 het Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
0.080 3.88E-6 YKR092C SRP40 hom Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140