YNL301C / RPL18B

Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL301C / RPL18B

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.26|P-value:1.99E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.14|P-value:3.31E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:2.85|P-value:9.96E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.51|P-value:6.93E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:2.97|P-value:6.45E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.35|P-value:1.40E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.03|P-value:5.45E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-2.91|P-value:8.38E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.04|P-value:5.13E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.42|P-value:1.05E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.12|P-value:3.84E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-4.89|P-value:6.30E-8 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.02|P-value:5.50E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.04|P-value:4.94E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.35|P-value:1.51E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.03|P-value:5.03E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:-3.11|P-value:3.91E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.34|P-value:3.86E-9 ID:SGTC_1145|Compound:3546-0597|FD-Score:-2.95|P-value:7.40E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.06|P-value:4.53E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.36|P-value:1.41E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:2.85|P-value:9.99E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.36|P-value:1.44E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.21|P-value:2.51E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.61|P-value:4.97E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-3.63|P-value:4.48E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.59|P-value:3.33E-7 ID:SGTC_1764|Compound:st044502|FD-Score:3.09|P-value:4.08E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.07|P-value:4.39E-4 ID:SGTC_1919|Compound:st067113|FD-Score:5.15|P-value:1.21E-8 ID:SGTC_1978|Compound:st071761|FD-Score:9.00|P-value:9.05E-23 ID:SGTC_1981|Compound:st071826|FD-Score:-5.02|P-value:2.91E-8 ID:SGTC_1984|Compound:st072354|FD-Score:-2.90|P-value:8.91E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.02|P-value:6.50E-6 ID:SGTC_2035|Compound:5154463|FD-Score:3.09|P-value:4.05E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-2.93|P-value:7.98E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-2.95|P-value:7.27E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.20|P-value:2.77E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.82|P-value:1.82E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.71|P-value:2.91E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.48|P-value:8.70E-5 ID:SGTC_2437|Compound:5741531|FD-Score:6.61|P-value:4.12E-13 ID:SGTC_2440|Compound:5628896|FD-Score:2.97|P-value:6.41E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.13|P-value:3.85E-6 ID:SGTC_2480|Compound:5767542|FD-Score:-2.93|P-value:7.99E-4 ID:SGTC_2487|Compound:5918373|FD-Score:2.91|P-value:8.11E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.40|P-value:1.12E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:2.94|P-value:7.18E-4 ID:SGTC_2591|Compound:skatole|FD-Score:2.96|P-value:6.55E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:2.98|P-value:6.22E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.14|P-value:3.31E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.15|P-value:3.21E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.20|P-value:2.73E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.42|P-value:1.05E-4 ID:SGTC_3027|Compound:9089541|FD-Score:-3.14|P-value:3.56E-4 ID:SGTC_3040|Compound:9091894|FD-Score:-4.23|P-value:2.52E-6 ID:SGTC_3091|Compound:9116372|FD-Score:-4.67|P-value:2.32E-7 ID:SGTC_3147|Compound:9097027|FD-Score:4.04|P-value:5.86E-6 ID:SGTC_3150|Compound:9097574|FD-Score:-4.09|P-value:5.02E-6 ID:SGTC_3151|Compound:9099821|FD-Score:3.65|P-value:3.73E-5 ID:SGTC_3154|Compound:9100113|FD-Score:4.55|P-value:4.18E-7 ID:SGTC_3156|Compound:9099931|FD-Score:2.89|P-value:8.44E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.12|P-value:3.86E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.91|P-value:8.59E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.15|P-value:3.20E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.26|P-value:1.99E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.14|P-value:3.31E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:2.85|P-value:9.96E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.51|P-value:6.93E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:2.97|P-value:6.45E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.35|P-value:1.40E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.03|P-value:5.45E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-2.91|P-value:8.38E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.04|P-value:5.13E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.42|P-value:1.05E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.12|P-value:3.84E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-4.89|P-value:6.30E-8 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.02|P-value:5.50E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.04|P-value:4.94E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.35|P-value:1.51E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.03|P-value:5.03E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:-3.11|P-value:3.91E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.34|P-value:3.86E-9 ID:SGTC_1145|Compound:3546-0597|FD-Score:-2.95|P-value:7.40E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.06|P-value:4.53E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.36|P-value:1.41E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:2.85|P-value:9.99E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.36|P-value:1.44E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.21|P-value:2.51E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.61|P-value:4.97E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-3.63|P-value:4.48E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.59|P-value:3.33E-7 ID:SGTC_1764|Compound:st044502|FD-Score:3.09|P-value:4.08E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.07|P-value:4.39E-4 ID:SGTC_1919|Compound:st067113|FD-Score:5.15|P-value:1.21E-8 ID:SGTC_1978|Compound:st071761|FD-Score:9.00|P-value:9.05E-23 ID:SGTC_1981|Compound:st071826|FD-Score:-5.02|P-value:2.91E-8 ID:SGTC_1984|Compound:st072354|FD-Score:-2.90|P-value:8.91E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.02|P-value:6.50E-6 ID:SGTC_2035|Compound:5154463|FD-Score:3.09|P-value:4.05E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-2.93|P-value:7.98E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-2.95|P-value:7.27E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.20|P-value:2.77E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.82|P-value:1.82E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.71|P-value:2.91E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.48|P-value:8.70E-5 ID:SGTC_2437|Compound:5741531|FD-Score:6.61|P-value:4.12E-13 ID:SGTC_2440|Compound:5628896|FD-Score:2.97|P-value:6.41E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.13|P-value:3.85E-6 ID:SGTC_2480|Compound:5767542|FD-Score:-2.93|P-value:7.99E-4 ID:SGTC_2487|Compound:5918373|FD-Score:2.91|P-value:8.11E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.40|P-value:1.12E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:2.94|P-value:7.18E-4 ID:SGTC_2591|Compound:skatole|FD-Score:2.96|P-value:6.55E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:2.98|P-value:6.22E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.14|P-value:3.31E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.15|P-value:3.21E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.20|P-value:2.73E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.42|P-value:1.05E-4 ID:SGTC_3027|Compound:9089541|FD-Score:-3.14|P-value:3.56E-4 ID:SGTC_3040|Compound:9091894|FD-Score:-4.23|P-value:2.52E-6 ID:SGTC_3091|Compound:9116372|FD-Score:-4.67|P-value:2.32E-7 ID:SGTC_3147|Compound:9097027|FD-Score:4.04|P-value:5.86E-6 ID:SGTC_3150|Compound:9097574|FD-Score:-4.09|P-value:5.02E-6 ID:SGTC_3151|Compound:9099821|FD-Score:3.65|P-value:3.73E-5 ID:SGTC_3154|Compound:9100113|FD-Score:4.55|P-value:4.18E-7 ID:SGTC_3156|Compound:9099931|FD-Score:2.89|P-value:8.44E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.12|P-value:3.86E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.91|P-value:8.59E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.15|P-value:3.20E-4

Top fitness defect scores for YNL301C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1978 st071761 9.00 42.0 µM 9.05E-23 TSC3-RPN4 2 1.08E-19
2 SGTC_2437 5741531 6.61 144.2 µM 4.12E-13 8 1.97E-11
3 SGTC_1919 st067113 5.15 52.3 µM 1.21E-8 TSC3-RPN4 13 1.31E-7
4 SGTC_1748 st037455 4.59 53.6 µM 3.33E-7 16 2.26E-6
5 SGTC_3154 9100113 4.55 49.5 µM 4.18E-7 18 2.74E-6
6 SGTC_2453 5731132 4.13 22.2 µM 3.85E-6 16 1.84E-5
7 SGTC_3147 9097027 4.04 49.5 µM 5.86E-6 21 2.64E-5
8 SGTC_2016 5121758 4.02 140.0 µM 6.50E-6 redox potentiating 49 2.89E-5
9 SGTC_2426 5582046 3.71 32.2 µM 2.91E-5 37 1.05E-4
10 SGTC_3151 9099821 3.65 49.5 µM 3.73E-5 29 1.30E-4
11 SGTC_41 0478-0632 3.51 82.6 µM 6.93E-5 43 2.21E-4
12 SGTC_472 calcifediol 3.42 10.0 µM 1.05E-4 16 3.16E-4
13 SGTC_2916 7875993 3.42 68.8 µM 1.05E-4 46 3.17E-4
14 SGTC_2519 cryptotanshinone 3.40 88.0 µM 1.12E-4 heme biosynthesis & mitochondrial translocase 28 3.35E-4
15 SGTC_321 4534-3890 3.35 65.3 µM 1.40E-4 RPP1 & pyrimidine depletion 12 4.04E-4
16 SGTC_25 0118-0223 3.26 35.7 µM 1.99E-4 42 5.48E-4
17 SGTC_1434 4073-0095 3.21 163.0 µM 2.51E-4 31 6.68E-4
18 SGTC_3291 9121177 3.15 71.4 µM 3.20E-4 36 8.24E-4
19 SGTC_2633 5,7-dihydroxyisoflavone 3.15 100.0 µM 3.21E-4 64 8.27E-4
20 SGTC_2615 purpurogallin-4-carboxylic acid 3.14 100.0 µM 3.31E-4 redox potentiating 109 8.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.11E-16 YKL141W SDH3 het Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex
0.127 1.39E-13 YMR135W-A_d YMR135W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.120 2.81E-12 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.120 3.61E-12 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.109 2.82E-10 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.109 2.88E-10 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.108 3.62E-10 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.105 1.01E-9 YJL158C CIS3 hom Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
0.105 1.28E-9 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.102 2.96E-9 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.096 2.35E-8 YML015C TAF11 het TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
0.094 4.52E-8 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.093 6.50E-8 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.093 7.31E-8 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.091 1.17E-7 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p